HitPredict

Interactor 1: CBX4 (O00257)
E3 SUMO-protein ligase CBX4 (EC 2.3.2.-) (Chromobox protein homolog 4) (Polycomb 2 homolog) (Pc2) (hPc2)
Gene: CBX4

Interactor 2: SCML2 (Q9UQR0)
Sex comb on midleg-like protein 2
Gene: SCML2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	37014752
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003682 - chromatin binding GO:0005634 - nucleus GO:0031519 - PcG protein complex GO:0045892 - negative regulation of DNA-templated transcription
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 560 Hs			1 700
+	Hs
		1059204 CBX2_HUMAN (2-559): 1.19e-82: 269: 23.54		SCML2_HUMAN (1-700): 0: 777: 100.00
+	Hs
		123280 CBX4_HUMAN (1-560): 7.58e-163: 477: 100.00		PHC2_HUMAN (211-697): 1.07e-85: 289: 15.99
+	Hs
		123234 CBX4_HUMAN (1-560): 7.58e-163: 477: 100.00		PHC1_HUMAN (455-696): 4.09e-47: 181: 21.57
+	Hs
		123290 CBX4_HUMAN (1-560): 7.58e-163: 477: 100.00		PHC3_HUMAN (445-697): 4.59e-41: 163: 20.30
+	Hs
		123342 CBX4_HUMAN (1-560): 7.58e-163: 477: 100.00		SCML1_HUMAN (471-698): 6.13e-32: 128: 29.54
+	Hs
		1059207 CBX2_HUMAN (2-559): 1.19e-82: 269: 23.54		LMBL1_HUMAN (129-679): 1.21e-99: 326: 15.98
+	Dr
		1193375 Q804D1_DANRE (1-558): 1.48e-100: 314: 40.50		PHC2_DANRE (253-697): 2.86e-78: 269: 17.04
+	Hs
		123303 CBX4_HUMAN (1-560): 7.58e-163: 477: 100.00		SCMH1_HUMAN (7-131): 9.67e-23: 105: 32.03
+	Hs
		1059170 CBX2_HUMAN (2-559): 1.19e-82: 269: 23.54		PHC2_HUMAN (211-697): 1.07e-85: 289: 15.99
+	Hs
		316088 CBX6_HUMAN (1-419): 4.68e-61: 209: 24.19		PHC2_HUMAN (211-697): 1.07e-85: 289: 15.99
+	Mm
		675498 CBX2_MOUSE (2-559): 8.06e-91: 290: 22.85		PHC1_MOUSE (220-696): 2.89e-48: 185: 13.94
+	Mm
		675500 CBX2_MOUSE (2-559): 8.06e-91: 290: 22.85		PHC3_MOUSE (445-697): 5.73e-42: 166: 20.30
+	Hs
		943062 CBX2_HUMAN (2-559): 1.19e-82: 269: 23.54		PHC1_HUMAN (455-696): 4.09e-47: 181: 21.57
+	Hs
		1059177 CBX2_HUMAN (2-559): 1.19e-82: 269: 23.54		PHC3_HUMAN (445-697): 4.59e-41: 163: 20.30
+	Hs
		1059202 CBX2_HUMAN (2-559): 1.19e-82: 269: 23.54		SCML1_HUMAN (471-698): 6.13e-32: 128: 29.54
+	Hs
		316005 CBX6_HUMAN (1-419): 4.68e-61: 209: 24.19		PHC1_HUMAN (455-696): 4.09e-47: 181: 21.57
+	Hs
		1059182 CBX2_HUMAN (2-559): 1.19e-82: 269: 23.54		SCMH1_HUMAN (7-131): 9.67e-23: 105: 32.03
+	Hs
		316103 CBX6_HUMAN (1-419): 4.68e-61: 209: 24.19		PHC3_HUMAN (445-697): 4.59e-41: 163: 20.30
+	Hs
		316200 CBX6_HUMAN (1-419): 4.68e-61: 209: 24.19		SCML1_HUMAN (471-698): 6.13e-32: 128: 29.54
+	Hs
		316124 CBX6_HUMAN (1-419): 4.68e-61: 209: 24.19		SCMH1_HUMAN (7-131): 9.67e-23: 105: 32.03