HitPredict

Interactor 1: CBR4 (Q8N4T8)
3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100) (3-ketoacyl-[acyl-carrier-protein] reductase beta subunit) (KAR beta subunit) (Carbonyl reductase family member 4) (CBR4) (Quinone reductase CBR4) (EC 1.6.5.10) (Short chain dehydrogenase/reductase family 45C member 1)
Gene: CBR4

Interactor 2: DHB8 (Q92506)
(3R)-3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.n12) (17-beta-hydroxysteroid dehydrogenase 8) (17-beta-HSD 8) (HSD17B8) (3-ketoacyl-[acyl-carrier-protein] reductase alpha subunit) (KAR alpha subunit) (3-oxoacyl-[acyl-carrier-protein] reductase) (Estradiol 17-beta-dehydrogenase 8) (EC 1.1.1.62) (Protein Ke6) (Ke6) (Short chain dehydrogenase/reductase family 30C member 1) (Testosterone 17-beta-dehydrogenase 8) (EC 1.1.1.239)
Gene: HSD17B8

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.861

Property	Details
Experiments	26186194, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	adh_short_C2~adh_short_C2
Common GO terms	GO:0005759 - mitochondrial matrix GO:0006633 - fatty acid biosynthetic process GO:0051290 - protein heterotetramerization GO:1990204 - oxidoreductase complex
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 237 Hs			1 261
+	Hs
		1312485 DHRS4_HUMAN (2-233): 1.16e-85: 257: 32.51		DHRS4_HUMAN (1-258): 2.68e-89: 267: 31.18
+	At
		1338081 TRNHF_ARATH (2-235): 2.72e-83: 250: 33.88		TRNHC_ARATH (4-261): 4.97e-86: 258: 31.15
+	At
		1338080 TRNHF_ARATH (2-235): 2.72e-83: 250: 33.88		SAG13_ARATH (1-261): 1.86e-85: 257: 30.15
+	At
		1378415 SAG13_ARATH (2-235): 1.8e-80: 243: 29.92		TRNHC_ARATH (4-261): 4.97e-86: 258: 31.15
+	At
		1378414 SAG13_ARATH (2-235): 1.8e-80: 243: 29.92		SAG13_ARATH (1-261): 1.86e-85: 257: 30.15
+	Ss
		1259264 DHRS4_PIG (2-233): 4.11e-81: 245: 30.45		DHRS4_PIG (1-258): 7.12e-84: 253: 31.18
+	Ec
		468348 FABG_ECOLI (2-236): 6.47e-83: 249: 41.25		FABG_ECOLI (7-261): 4.78e-82: 247: 37.26
+	At
		1378411 SAG13_ARATH (2-235): 1.8e-80: 243: 29.92		TRNH8_ARATH (4-261): 1.18e-82: 250: 27.31
+	At
		1338079 TRNHF_ARATH (2-235): 2.72e-83: 250: 33.88		TRNHA_ARATH (4-261): 2.79e-79: 241: 27.69
+	Dm
		1248591 Q8SX57_DROME (2-236): 4.84e-79: 239: 34.00		Q8SX57_DROME (6-260): 2.22e-82: 249: 28.35
+	At
		1378413 SAG13_ARATH (2-235): 1.8e-80: 243: 29.92		TRNH9_ARATH (4-261): 5.88e-81: 245: 27.97
+	At
		1247364 SAG13_ARATH (2-235): 1.8e-80: 243: 29.92		TRNH2_ARATH (5-261): 1.92e-80: 244: 28.19
+	At
		96439 SAG13_ARATH (2-235): 1.8e-80: 243: 29.92		F4IKL8_ARATH (25-259): 1.41e-79: 241: 25.32
+	Dm
		1248593 Q8SX57_DROME (2-236): 4.84e-79: 239: 34.00		Q9VNF3_DROME (6-260): 1.54e-80: 244: 27.59
+	Dm
		1214104 Q8SX57_DROME (2-236): 4.84e-79: 239: 34.00		Q8IPP8_DROME (7-260): 1.35e-79: 241: 26.54
+	Dm
		1214105 Q8IPP8_DROME (2-236): 9.91e-78: 236: 34.00		Q9VNF3_DROME (6-260): 1.54e-80: 244: 27.59