Protein: DESI1
Desumoylating isopeptidase 1 (DeSI-1) (EC 3.4.-.-) (PPPDE peptidase domain-containing protein 2) (Palmitoyl protein thioesterase DESI1) (EC 3.1.2.22) (Polyubiquitinated substrate transporter) (POST) (S-depalmitoylase DESI1)

Gene: DESI1
Organism: Homo sapiens
Interactions: 65
UniProt ID: Q6ICB0

Gene Ontology (top 5):
GO:0005634 - nucleus
GO:0005829 - cytosol
GO:0006508 - proteolysis
GO:0006611 - protein export from nucleus
GO:0008474 - palmitoyl-(protein) hydrolase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1233871

UBQL2
Ubiquilin-2

4

6

Small-scale

0.684

High

508140

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

3

4

Small-scale

0.658

High

1233872

UBQL1
Ubiquilin-1

3

6

Small-scale

0.653

High

507231

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

2

4

High-throughput

0.606

High

987074

RS27A
Ubiquitin-ribosomal protein eS31 fusion protein

2

4

High-throughput

0.606

High

987384

RL40
Ubiquitin-ribosomal protein eL40 fusion protein

2

4

High-throughput

0.606

High

1233858

UBQLN
Ubiquilin-like protein

2

6

High-throughput

0.606

High

1233867

CDIP1
Cell death-inducing p53-target protein 1

2

0

High-throughput

0.589

High

1004705

RNF4
E3 ubiquitin-protein ligase RNF4

2

0

High-throughput

0.580

High

1017550

PRR5
Proline-rich protein 5

2

0

High-throughput

0.580

High

1098714

NDK3
Nucleoside diphosphate kinase 3

2

0

High-throughput

0.580

High

1139060

DAZP2
DAZ-associated protein 2

2

0

High-throughput

0.580

High

1233864

UHRF2
E3 ubiquitin-protein ligase UHRF2

2

0

High-throughput

0.580

High

1233866

5NT3A
Cytosolic 5'-nucleotidase 3A

2

0

High-throughput

0.580

High

1233857

ZBT46
Zinc finger and BTB domain-containing protein 46

1

1

Small-scale

0.561

High

289357

CTAG2
Cancer/testis antigen 2

2

1

High-throughput

0.553

High

1006261

CTG1B
Cancer/testis antigen 1

2

1

High-throughput

0.553

High

374684

RASH
GTPase HRas

1

3

High-throughput

0.536

High

1232402

Q6FHY5
MEOX2 protein

1

1

High-throughput

0.515

High

874803

SPB4
Serpin B4

1

0

High-throughput

0.513

High

1109820

HDAC1
Histone deacetylase 1

1

0

High-throughput

0.513

High

893937

MEOX2
Homeobox protein MOX-2

1

1

High-throughput

0.481

High

172943

XPO1
Exportin-1

1

0

Small-scale

0.480

High

127998

PSD11
26S proteasome non-ATPase regulatory subunit 11

1

1

Small-scale

0.479

High

128258

PSD12
26S proteasome non-ATPase regulatory subunit 12

1

1

Small-scale

0.479

High

165356

PSA7
Proteasome subunit alpha type-7

1

5

Small-scale

0.479

High

610376

PRS6A
26S proteasome regulatory subunit 6A

1

4

Small-scale

0.479

High

633718

PSB1
Proteasome subunit beta type-1

1

6

Small-scale

0.479

High

680915

PSA1
Proteasome subunit alpha type-1

1

5

Small-scale

0.479

High

681183

PSA2
Proteasome subunit alpha type-2

1

6

Small-scale

0.479

High

681668

PSA4
Proteasome subunit alpha type-4

1

5

Small-scale

0.479

High

700664

PSA5
Proteasome subunit alpha type-5

1

5

Small-scale

0.479

High

701172

PSB5
Proteasome subunit beta type-5

1

4

Small-scale

0.479

High

778711

PRS7
26S proteasome regulatory subunit 7

1

2

Small-scale

0.479

High

851353

PRS6B
26S proteasome regulatory subunit 6B

1

2

Small-scale

0.479

High

856739

BAG6
Large proline-rich protein BAG6

1

5

Small-scale

0.479

High

887553

PSB3
Proteasome subunit beta type-3

1

4

Small-scale

0.479

High

933667

PSMD4
26S proteasome non-ATPase regulatory subunit 4

1

1

Small-scale

0.479

High

954836

PSA6
Proteasome subunit alpha type-6

1

6

Small-scale

0.479

High

968736

PRS4
26S proteasome regulatory subunit 4

1

2

Small-scale

0.479

High

968958

PRS8
26S proteasome regulatory subunit 8

1

3

Small-scale

0.479

High

1233861

PSMA8
Proteasome subunit alpha-type 8

1

6

Small-scale

0.479

High

1233865

PSB7
Proteasome subunit beta type-7

1

3

Small-scale

0.479

High

1233868

UBQL4
Ubiquilin-4

1

7

Small-scale

0.479

High

46367

A0A1U9X8X8
Corneodesmosin

1

1

High-throughput

0.470

High

1195471

Q4KN05
KLRF1 protein

1

1

High-throughput

0.470

High

675057

TNR6
Tumor necrosis factor receptor superfamily member 6

1

0

High-throughput

0.458

High

874169

PSMD8
26S proteasome non-ATPase regulatory subunit 8

1

0

Small-scale

0.458

High

934218

BI1
Bax inhibitor 1

1

0

Small-scale

0.458

High

965729

HNRPK
Heterogeneous nuclear ribonucleoprotein K

1

0

Small-scale

0.458

High

1149507

CDSN
Corneodesmosin

1

1

High-throughput

0.439

High

1233869

KLRF1
Killer cell lectin-like receptor subfamily F member 1

1

1

High-throughput

0.439

High

716190

ERP29
Endoplasmic reticulum resident protein 29

2

0

High-throughput

0.316

High

761153

EVI2B
Protein EVI2B

2

0

High-throughput

0.316

High

947884

T2R41
Taste receptor type 2 member 41

2

0

High-throughput

0.316

High

1185185

SMI21
Small integral membrane protein 21

2

0

High-throughput

0.316

High

1233859

SHSA5
Protein shisa-5

2

0

High-throughput

0.316

High

1233860

GOLM1
Golgi membrane protein 1

2

0

High-throughput

0.316

High

1233862

AGR3
Anterior gradient protein 3

2

0

High-throughput

0.316

High

1233863

SHSA4
Protein shisa-4

2

0

High-throughput

0.316

High

1233870

ABI3
ABI gene family member 3

2

0

High-throughput

0.316

High

1208206

SPXN5
Sperm protein associated with the nucleus on the X chromosome N5

1

0

High-throughput

0.279

Low

1233856

PLPR4
Phospholipid phosphatase-related protein type 4

1

0

High-throughput

0.279

Low

640749

FGF7
Fibroblast growth factor 7

1

0

High-throughput

0.251

Low

1208143

CD158
Coiled-coil domain-containing protein 158

1

0

High-throughput

0.251

Low


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Last updated: 11Aug2025