HitPredict

Interactor 1: AT11C (Q8NB49)
Phospholipid-transporting ATPase IG (EC 7.6.2.1) (ATPase IQ) (ATPase class VI type 11C) (P4-ATPase flippase complex alpha subunit ATP11C)
Gene: ATP11C

Interactor 2: CC50A (Q9NV96)
Cell cycle control protein 50A (P4-ATPase flippase complex beta subunit TMEM30A) (Transmembrane protein 30A)
Gene: TMEM30A

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.73	1.00	0.855

Property	Details
Experiments	33961781, 21914794, 31571211
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	CDC50~E1-E2_ATPase, CDC50~PhoLip_ATPase_C, CDC50~PhoLip_ATPase_N
Common GO terms	GO:0005783 - endoplasmic reticulum GO:0005886 - plasma membrane GO:0031901 - early endosome membrane GO:0045332 - phospholipid translocation GO:1990531 - phospholipid-translocating ATPase complex
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 1132 Hs			1 361
+	Hs
		958352 AT11A_HUMAN (13-1129): 0: 972: 64.06		CC50A_HUMAN (1-361): 0: 546: 100.00
+	Hs
		1346391 AT8A1_HUMAN (6-1132): 0: 938: 33.28		CC50A_HUMAN (1-361): 0: 546: 100.00
+	Hs
		1345687 AT8A2_HUMAN (2-1132): 0: 935: 32.78		CC50A_HUMAN (1-361): 0: 546: 100.00
+	Hs
		958374 AT8B2_HUMAN (2-1129): 0: 913: 32.59		CC50A_HUMAN (1-361): 0: 546: 100.00
+	Mm
		936935 AT8A1_MOUSE (6-1132): 0: 938: 33.54		CC50A_MOUSE (1-361): 0: 510: 88.46
+	Hs
		1346389 AT11B_HUMAN (7-1127): 0: 896: 51.88		CC50A_HUMAN (1-361): 0: 546: 100.00
+	Hs
		206705 AT8B1_HUMAN (39-1132): 0: 879: 31.16		CC50A_HUMAN (1-361): 0: 546: 100.00
+	Hs
		1257203 AT8B4_HUMAN (13-1112): 0: 877: 32.84		CC50A_HUMAN (1-361): 0: 546: 100.00
+	Hs
		958356 AT8B2_HUMAN (2-1129): 0: 913: 32.59		CC50B_HUMAN (22-350): 6.35e-155: 441: 53.71
+	Hs
		206704 AT8B1_HUMAN (39-1132): 0: 879: 31.16		CC50B_HUMAN (22-350): 6.35e-155: 441: 53.71
+	Sc
		636200 ATC3_YEAST (14-1128): 0: 905: 33.19		CDC50_YEAST (14-353): 5.73e-138: 399: 33.78
+	Sc
		762181 ATC3_YEAST (14-1128): 0: 905: 33.19		LEM3_YEAST (22-344): 2.17e-118: 350: 31.58
+	Sc
		636198 ATC5_YEAST (111-1106): 0: 771: 29.40		CDC50_YEAST (14-353): 5.73e-138: 399: 33.78
+	Sc
		697481 ATC5_YEAST (111-1106): 0: 771: 29.40		LEM3_YEAST (22-344): 2.17e-118: 350: 31.58
+	Hs
		1346381 AT10D_HUMAN (23-543): 6.45e-160: 514: 28.73		CC50A_HUMAN (1-361): 0: 546: 100.00
+	Hs
		297010 AT10B_HUMAN (23-436): 4.12e-157: 507: 35.01		CC50A_HUMAN (1-361): 0: 546: 100.00
+	Hs
		231024 AT10A_HUMAN (32-483): 1.59e-154: 501: 33.19		CC50A_HUMAN (1-361): 0: 546: 100.00
+	Sc
		791158 ATC4_YEAST (8-144): 7.76e-21: 101: 27.66		LEM3_YEAST (22-344): 2.17e-118: 350: 31.58