HitPredict

Interactor 1: TAF4 (O00268)
Transcription initiation factor TFIID subunit 4 (RNA polymerase II TBP-associated factor subunit C) (TBP-associated factor 4) (Transcription initiation factor TFIID 130 kDa subunit) (TAF(II)130) (TAFII-130) (TAFII130) (Transcription initiation factor TFIID 135 kDa subunit) (TAF(II)135) (TAFII-135) (TAFII135)
Gene: TAF4

Interactor 2: TBP (P20226)
TATA-box-binding protein (TATA sequence-binding protein) (TATA-binding factor) (TATA-box factor) (Transcription initiation factor TFIID TBP subunit)
Gene: TBP

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.94	1.00	0.970

The method score is based on:

Property	Details
Experiments	12665565, 9153318, 35271311, 19240132, 17967894, 8858156, 9603525, 22323595, 9674425, 10373431
Identification Methods	affinity chromatography technology, biochemical, pull down, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	physical association, association, direct interaction

The annotation score is based on:

Property	Details
Interacting Pfam domains	TAF4~TBP
Common GO terms	GO:0000785 - chromatin GO:0001673 - male germ cell nucleus GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005669 - transcription factor TFIID complex and 9 others more... GO:0006352 - DNA-templated transcription initiation GO:0006366 - transcription by RNA polymerase II GO:0006367 - transcription initiation at RNA polymerase II promoter GO:0016251 - RNA polymerase II general transcription initiation factor activity GO:0017162 - aryl hydrocarbon receptor binding GO:0032991 - protein-containing complex GO:0042789 - mRNA transcription by RNA polymerase II GO:0051123 - RNA polymerase II preinitiation complex assembly GO:0060261 - positive regulation of transcription initiation by RNA polymerase II
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1	1085
Hs

1	339

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024