Protein: KMT2C
Histone-lysine N-methyltransferase 2C (Lysine N-methyltransferase 2C) (EC 2.1.1.364) (Homologous to ALR protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 3)

Gene: KMT2C
Organism: Homo sapiens
Interactions: 134
UniProt ID: Q8NEZ4

Gene Ontology (top 5):
GO:0003677 - DNA binding
GO:0003713 - transcription coactivator activity
GO:0003723 - RNA binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1338281

ASH2L
Set1/Ash2 histone methyltransferase complex subunit ASH2

14

20

Small-scale

0.983

High

1145497

RBBP5
Retinoblastoma-binding protein 5

11

20

Small-scale

0.978

High

980015

H4
Histone H4

4

13

Small-scale

0.888

High

194588

KDM6A
Lysine-specific demethylase 6A

3

20

Small-scale

0.847

High

998565

H31
Histone H3.1

3

20

Small-scale

0.845

High

1258883

H32
Histone H3.2

2

20

Small-scale

0.778

High

965097

WDR5
WD repeat-containing protein 5

11

20

Small-scale

0.756

High

1130579

NCOA6
Nuclear receptor coactivator 6

6

20

Small-scale

0.734

High

158698

UTY
Histone demethylase UTY

1

20

High-throughput

0.691

High

550367

PABP1
Polyadenylate-binding protein 1

1

13

High-throughput

0.665

High

1257080

PAXI1
PAX-interacting protein 1

3

20

Small-scale

0.662

High

1338270

PAGR1
PAXIP1-associated glutamate-rich protein 1

3

2

Small-scale

0.656

High

419093

H2A1B
Histone H2A type 1-B/E

1

20

Small-scale

0.647

High

754917

H2B1B
Histone H2B type 1-B

1

20

Small-scale

0.647

High

1161950

H31T
Histone H3.1t

1

20

Small-scale

0.647

High

991637

DYL1
Dynein light chain 1, cytoplasmic

2

4

High-throughput

0.628

High

161491

KMT2D
Histone-lysine N-methyltransferase 2D

1

20

High-throughput

0.618

High

175910

SET1A
Histone-lysine N-methyltransferase SETD1A

1

18

High-throughput

0.618

High

224325

BUB3
Mitotic checkpoint protein BUB3

1

20

High-throughput

0.618

High

322668

KDM4B
Lysine-specific demethylase 4B

1

14

Small-scale

0.618

High

980938

H2B1C
Histone H2B type 1-C/E/F/G/I

1

20

High-throughput

0.618

High

1017037

H33
Histone H3.3

1

20

Small-scale

0.618

High

1041559

KMT2A
Histone-lysine N-methyltransferase 2A

1

19

High-throughput

0.618

High

1155553

EZH2
Histone-lysine N-methyltransferase EZH2

1

18

High-throughput

0.618

High

1220666

RN123
E3 ubiquitin-protein ligase RNF123

1

20

High-throughput

0.618

High

1250017

WDR82
WD repeat-containing protein 82

1

20

Small-scale

0.618

High

1338279

CXXC1
CXXC-type zinc finger protein 1

1

20

High-throughput

0.618

High

1338285

KMT2B
Histone-lysine N-methyltransferase 2B

1

17

High-throughput

0.618

High

1338286

SET1B
Histone-lysine N-methyltransferase SETD1B

1

17

High-throughput

0.618

High

1338265

DYL2
Dynein light chain 2, cytoplasmic

2

4

High-throughput

0.611

High

1133540

NFIX
Nuclear factor 1 X-type

2

20

High-throughput

0.601

High

1338272

DPY30
Protein dpy-30 homolog

2

8

Small-scale

0.595

High

1337790

DP13B
DCC-interacting protein 13-beta

2

8

High-throughput

0.594

High

143124

NFIB
Nuclear factor 1 B-type

2

20

High-throughput

0.584

High

242330

PRKN
E3 ubiquitin-protein ligase parkin

2

10

High-throughput

0.584

High

396547

ESR1
Estrogen receptor

2

20

High-throughput

0.571

High

430146

JUN
Transcription factor Jun

1

10

High-throughput

0.541

High

1158137

MK14
Mitogen-activated protein kinase 14

1

3

High-throughput

0.541

High

1055829

RING1
E3 ubiquitin-protein ligase RING1

1

20

High-throughput

0.536

High

1240660

CDC73
Parafibromin

1

4

Small-scale

0.536

High

1086639

SNF5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1

1

9

Small-scale

0.527

High

379021

PIGR
Polymeric immunoglobulin receptor

1

0

Small-scale

0.517

High

365766

KAD1
Adenylate kinase isoenzyme 1

1

3

High-throughput

0.515

High

697962

CALR
Calreticulin

1

5

High-throughput

0.515

High

1105057

TCOF
Treacle protein

1

20

High-throughput

0.515

High

1152445

T22D1
TSC22 domain family protein 1

1

20

High-throughput

0.508

High

414246

P53
Cellular tumor antigen p53

1

7

Small-scale

0.500

High

1338268

ERP44
Endoplasmic reticulum resident protein 44

1

9

High-throughput

0.489

High

71456

P20L1
PHD finger protein 20-like protein 1

1

12

High-throughput

0.479

High

129265

MEN1
Menin

1

9

High-throughput

0.479

High

165380

PSA7
Proteasome subunit alpha type-7

1

3

High-throughput

0.479

High

181537

TBXT
T-box transcription factor T

1

10

High-throughput

0.479

High

185866

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

18

Small-scale

0.479

High

210056

CRX
Cone-rod homeobox protein

1

20

High-throughput

0.479

High

216961

KLF4
Krueppel-like factor 4

1

20

High-throughput

0.479

High

225064

TLX3
T-cell leukemia homeobox protein 3

1

20

High-throughput

0.479

High

226574

TLX2
T-cell leukemia homeobox protein 2

1

20

High-throughput

0.479

High

370726

FOS
Protein c-Fos

1

12

High-throughput

0.479

High

378510

IL1A
Interleukin-1 alpha

1

2

Small-scale

0.479

High

468609

HS90B
Heat shock protein HSP 90-beta

1

15

High-throughput

0.479

High

474133

NFIC
Nuclear factor 1 C-type

1

20

High-throughput

0.479

High

520207

ANDR
Androgen receptor

1

20

High-throughput

0.479

High

538437

EGR2
E3 SUMO-protein ligase EGR2

1

12

High-throughput

0.479

High

540909

ERG
Transcriptional regulator ERG

1

20

High-throughput

0.479

High

581693

MYOD1
Myoblast determination protein 1

1

16

High-throughput

0.479

High

589199

RFA2
Replication protein A 32 kDa subunit

1

7

High-throughput

0.479

High

635203

HNF1A
Hepatocyte nuclear factor 1-alpha

1

7

High-throughput

0.479

High

662249

PAX7
Paired box protein Pax-7

1

20

High-throughput

0.479

High

662461

GATA2
Endothelial transcription factor GATA-2

1

20

High-throughput

0.479

High

685267

PAX6
Paired box protein Pax-6

1

20

High-throughput

0.479

High

695981

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

8

High-throughput

0.479

High

703171

TEAD1
Transcriptional enhancer factor TEF-1

1

5

High-throughput

0.479

High

725285

TLX1
T-cell leukemia homeobox protein 1

1

20

High-throughput

0.479

High

768681

RFA3
Replication protein A 14 kDa subunit

1

7

High-throughput

0.479

High

775882

HNF1B
Hepatocyte nuclear factor 1-beta

1

20

High-throughput

0.479

High

789528

PPARG
Peroxisome proliferator-activated receptor gamma

1

20

High-throughput

0.479

High

833993

HNF4A
Hepatocyte nuclear factor 4-alpha

1

20

High-throughput

0.479

High

862306

YAP1
Transcriptional coactivator YAP1

1

20

High-throughput

0.479

High

872546

SOX2
Transcription factor SOX-2

1

20

High-throughput

0.479

High

873102

SOX9
Transcription factor SOX-9

1

20

High-throughput

0.479

High

877533

LHX1
LIM/homeobox protein Lhx1

1

20

High-throughput

0.479

High

887035

CEBPA
CCAAT/enhancer-binding protein alpha

1

12

High-throughput

0.479

High

895758

LHX2
LIM/homeobox protein Lhx2

1

20

High-throughput

0.479

High

905446

HCFC1
Host cell factor 1

1

20

High-throughput

0.479

High

928302

ATN1
Atrophin-1

1

20

High-throughput

0.479

High

937827

FOXA1
Hepatocyte nuclear factor 3-alpha

1

16

High-throughput

0.479

High

938480

PAX9
Paired box protein Pax-9

1

20

High-throughput

0.479

High

942450

GSC
Homeobox protein goosecoid

1

20

High-throughput

0.479

High

992033

RL38
Large ribosomal subunit protein eL38

1

3

High-throughput

0.479

High

1040063

PAX2
Paired box protein Pax-2

1

20

High-throughput

0.479

High

1052893

HME1
Homeobox protein engrailed-1

1

18

High-throughput

0.479

High

1056627

PAX8
Paired box protein Pax-8

1

20

High-throughput

0.479

High

1087875

NFIA
Nuclear factor 1 A-type

1

20

High-throughput

0.479

High

1091231

FOXI1
Forkhead box protein I1

1

16

High-throughput

0.479

High

1091319

FOXL1
Forkhead box protein L1

1

16

High-throughput

0.479

High

1113742

CUL3
Cullin-3

1

14

High-throughput

0.479

High

1118737

KLF5
Krueppel-like factor 5

1

20

High-throughput

0.479

High

1141793

EEA1
Early endosome antigen 1

1

18

High-throughput

0.479

High

1143196

PLEC
Plectin

1

10

High-throughput

0.479

High

1145822

IRF4
Interferon regulatory factor 4

1

7

High-throughput

0.479

High

1153838

SMAD2
Mothers against decapentaplegic homolog 2

1

14

Small-scale

0.479

High

1160870

TBR1
T-box brain protein 1

1

10

High-throughput

0.479

High

1260603

ASXL2
Putative Polycomb group protein ASXL2

1

20

Small-scale

0.479

High

1276505

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

11

High-throughput

0.479

High

1312397

ASXL1
Polycomb group protein ASXL1

1

6

Small-scale

0.479

High

1333161

KDM1B
Lysine-specific histone demethylase 2

1

10

Small-scale

0.479

High

1336792

TNR6A
Trinucleotide repeat-containing gene 6A protein

1

20

Small-scale

0.479

High

1338258

FBX22
F-box only protein 22

1

2

High-throughput

0.479

High

1338259

BD1L1
Biorientation of chromosomes in cell division protein 1-like 1

1

20

High-throughput

0.479

High

1338260

NUP35
Nucleoporin NUP35

1

2

High-throughput

0.479

High

1338261

SP7
Transcription factor Sp7

1

20

High-throughput

0.479

High

1338262

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

2

Small-scale

0.479

High

1338263

ESR2
Estrogen receptor beta

1

20

High-throughput

0.479

High

1338264

LHX4
LIM/homeobox protein Lhx4

1

20

High-throughput

0.479

High

1338266

FEV
Protein FEV

1

20

High-throughput

0.479

High

1338267

ASCL2
Achaete-scute homolog 2

1

18

Small-scale

0.479

High

1338269

SOX7
Transcription factor SOX-7

1

20

High-throughput

0.479

High

1338271

PHF20
PHD finger protein 20

1

20

High-throughput

0.479

High

1338273

ASXL3
Putative Polycomb group protein ASXL3

1

20

Small-scale

0.479

High

1338275

SOX17
Transcription factor SOX-17

1

20

High-throughput

0.479

High

1338276

RENT2
Regulator of nonsense transcripts 2

1

1

High-throughput

0.479

High

1338277

GCM1
Chorion-specific transcription factor GCMa

1

3

High-throughput

0.479

High

1338280

KANL3
KAT8 regulatory NSL complex subunit 3

1

4

High-throughput

0.479

High

1338282

LHX3
LIM/homeobox protein Lhx3

1

20

High-throughput

0.479

High

1338283

KLF15
Krueppel-like factor 15

1

20

High-throughput

0.479

High

1338284

ELF5
ETS-related transcription factor Elf-5

1

20

High-throughput

0.479

High

1338287

HCFC2
Host cell factor 2

1

20

High-throughput

0.479

High

1338274

CLPB
Mitochondrial disaggregase

1

2

High-throughput

0.470

High

880941

MTR1B
Melatonin receptor type 1B

1

2

High-throughput

0.464

High

124408

HAX1
HCLS1-associated protein X-1

1

0

Small-scale

0.458

High

1338278

GRHL1
Grainyhead-like protein 1 homolog

1

5

High-throughput

0.445

High

1214883

WLS
Protein wntless homolog

1

0

Small-scale

0.438

High

106308

APRIO
Alternative prion protein

1

3

High-throughput

0.437

High

1126128

GRM2
Metabotropic glutamate receptor 2

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025