HitPredict

Interactor 1: KDM2B (Q8NHM5)
Lysine-specific demethylase 2B (EC 1.14.11.27) (CXXC-type zinc finger protein 2) (F-box and leucine-rich repeat protein 10) (F-box protein FBL10) (F-box/LRR-repeat protein 10) (JmjC domain-containing histone demethylation protein 1B) (Jumonji domain-containing EMSY-interactor methyltransferase motif protein) (Protein JEMMA) (Protein-containing CXXC domain 2) ([Histone-H3]-lysine-36 demethylase 1B)
Gene: KDM2B

Interactor 2: PCGF6 (Q9BYE7)
Polycomb group RING finger protein 6 (Mel18 and Bmi1-like RING finger) (RING finger protein 134)
Gene: PCGF6

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	24981860
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006338 - chromatin remodeling GO:0006357 - regulation of transcription by RNA polymerase II and 1 others more... GO:0031519 - PcG protein complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1336 Hs			1 350
+	Hs
		718034 KDM2B_HUMAN (1-1336): 0: 1220: 100.00		BMI1_HUMAN (117-349): 8.67e-71: 225: 34.30
+	Hs
		718413 KDM2B_HUMAN (1-1336): 0: 1220: 100.00		PCGF2_HUMAN (117-350): 6.32e-65: 211: 33.47
+	Hs
		1108521 KDM2B_HUMAN (1-1336): 0: 1220: 100.00		PCGF3_HUMAN (120-341): 3.31e-65: 208: 34.44
+	Hs
		1245590 KDM2B_HUMAN (1-1336): 0: 1220: 100.00		PCGF1_HUMAN (119-347): 3.16e-60: 196: 34.91
+	Hs
		1197574 KDM2B_HUMAN (1-1336): 0: 1220: 100.00		PCGF5_HUMAN (117-344): 6.93e-50: 169: 31.73
+	Mm
		639474 KDM2B_MOUSE (43-1336): 0: 1146: 94.45		BMI1_MOUSE (117-349): 7.79e-70: 222: 35.00
+	Hs
		1245587 KDM2B_HUMAN (1-1336): 0: 1220: 100.00		RING2_HUMAN (85-303): 3.51e-32: 124: 14.49
+	Mm
		1158236 KDM2B_MOUSE (43-1336): 0: 1146: 94.45		PCGF1_MOUSE (119-347): 7.81e-60: 194: 35.35
+	Hs
		987996 KDM2B_HUMAN (1-1336): 0: 1220: 100.00		RING1_HUMAN (109-211): 1.44e-25: 108: 25.96
+	Mm
		1158239 KDM2B_MOUSE (43-1336): 0: 1146: 94.45		RING2_MOUSE (85-303): 2.38e-32: 125: 14.49
+	Mm
		193408 KDM2B_MOUSE (43-1336): 0: 1146: 94.45		RING1_MOUSE (109-211): 8.51e-26: 108: 25.96
+	Hs
		718320 PHF8_HUMAN (22-1018): 0: 637: 20.63		BMI1_HUMAN (117-349): 8.67e-71: 225: 34.30
+	Dm
		1367224 JHD1_DROME (46-1233): 0: 600: 24.77		Q9VV77_DROME (120-344): 1.81e-62: 200: 37.45
+	Dm
		728809 JHD1_DROME (46-1233): 0: 600: 24.77		PSC_DROME (42-349): 1.28e-53: 192: 28.08
+	Hs
		1019385 PHF8_HUMAN (22-1018): 0: 637: 20.63		TRI26_HUMAN (121-315): 1.51e-31: 126: 19.90
+	Dm
		627171 JHD1_DROME (46-1233): 0: 600: 24.77		SUZ2_DROME (102-344): 1.15e-39: 151: 20.72
+	Dm
		1361711 JHD1_DROME (46-1233): 0: 600: 24.77		RING1_DROME (108-243): 1.25e-26: 111: 22.63
+	Hs
		1311563 KDM2A_HUMAN (845-1336): 9.67e-66: 246: 41.46		PCGF1_HUMAN (119-347): 3.16e-60: 196: 34.91
+	Hs
		718044 FBX41_HUMAN (771-1298): 6.44e-50: 194: 18.11		BMI1_HUMAN (117-349): 8.67e-71: 225: 34.30
+	Hs
		584946 SKP2_HUMAN (981-1333): 1.57e-47: 178: 17.91		RO52_HUMAN (121-311): 4.15e-35: 135: 17.79