Protein: TLK1
Serine/threonine-protein kinase tousled-like 1 (EC 2.7.11.1) (PKU-beta) (Tousled-like kinase 1)

Gene: TLK1
Organism: Homo sapiens
Interactions: 63
UniProt ID: Q9UKI8

Gene Ontology (top 5):
GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0006325 - chromatin organization

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1288393

TLK2
Serine/threonine-protein kinase tousled-like 2

7

17

Small-scale

0.967

High

1461096

TLK1
Serine/threonine-protein kinase tousled-like 1

4

18

Small-scale

0.902

High

517609

ZSC22
Zinc finger and SCAN domain-containing protein 22

2

1

High-throughput

0.783

High

1185840

ZN829
Zinc finger protein 829

2

1

High-throughput

0.783

High

1245594

ZN773
Zinc finger protein 773

2

1

High-throughput

0.783

High

1461098

ASF1A
Histone chaperone ASF1A

7

7

Small-scale

0.750

High

1330250

ZN655
Zinc finger protein 655

2

0

High-throughput

0.742

High

1390747

DYL2
Dynein light chain 2, cytoplasmic

6

5

High-throughput

0.731

High

170419

AURKA
Aurora kinase A

1

16

Small-scale

0.724

High

991760

DYL1
Dynein light chain 1, cytoplasmic

5

5

High-throughput

0.720

High

1450750

ASF1B
Histone chaperone ASF1B

5

7

Small-scale

0.718

High

691875

MK03
Mitogen-activated protein kinase 3

1

20

High-throughput

0.691

High

1053765

PTN11
Tyrosine-protein phosphatase non-receptor type 11

3

4

High-throughput

0.667

High

163190

CHK1
Serine/threonine-protein kinase Chk1

1

10

Small-scale

0.647

High

262146

NBN
Nibrin

1

1

Small-scale

0.647

High

1447986

BATF3
Basic leucine zipper transcriptional factor ATF-like 3

2

4

High-throughput

0.628

High

995885

ACTC
Actin, alpha cardiac muscle 1

1

6

High-throughput

0.618

High

1391842

AURKB
Aurora kinase B

1

16

High-throughput

0.618

High

1399976

UHRF2
E3 ubiquitin-protein ligase UHRF2

1

2

Small-scale

0.618

High

1158046

HLF
Hepatic leukemia factor

2

6

High-throughput

0.612

High

685384

PAX6
Paired box protein Pax-6

2

8

High-throughput

0.606

High

895816

LHX2
LIM/homeobox protein Lhx2

2

3

High-throughput

0.606

High

1086345

TFCP2
Alpha-globin transcription factor CP2

2

1

High-throughput

0.606

High

1244651

GASP3
G protein-coupled receptor associated sorting protein 3

2

2

High-throughput

0.606

High

1271233

DPPA4
Developmental pluripotency-associated protein 4

2

0

High-throughput

0.580

High

1314066

YAF2
YY1-associated factor 2

2

0

High-throughput

0.580

High

1384700

PINX1
PIN2/TERF1-interacting telomerase inhibitor 1

2

0

High-throughput

0.580

High

1219201

SPAT1
Spermatogenesis-associated protein 1

2

1

High-throughput

0.574

High

1454115

LUZP4
Leucine zipper protein 4

1

0

High-throughput

0.549

High

972115

1433E
14-3-3 protein epsilon

1

18

High-throughput

0.541

High

1406174

RAD9A
Cell cycle checkpoint control protein RAD9A

1

0

Small-scale

0.537

High

775480

DDIT3
DNA damage-inducible transcript 3 protein

1

1

High-throughput

0.536

High

926695

HIRA
Protein HIRA

1

7

High-throughput

0.536

High

968476

PP1B
Serine/threonine-protein phosphatase PP1-beta catalytic subunit

1

20

High-throughput

0.536

High

1394395

ABHEB
Putative protein-lysine deacylase ABHD14B

1

1

High-throughput

0.536

High

388097

MBP
Myelin basic protein

1

1

Small-scale

0.501

High

1147584

UBE3C
Ubiquitin-protein ligase E3C

1

20

High-throughput

0.494

High

568598

TNNT1
Troponin T, slow skeletal muscle

1

1

High-throughput

0.489

High

714507

PML
Protein PML

1

9

High-throughput

0.479

High

887316

CEBPA
CCAAT/enhancer-binding protein alpha

1

4

High-throughput

0.479

High

979339

RS6
Small ribosomal subunit protein eS6

1

2

High-throughput

0.479

High

998931

H31
Histone H3.1

1

11

High-throughput

0.479

High

1088089

NFIA
Nuclear factor 1 A-type

1

2

High-throughput

0.479

High

1089059

TP53B
TP53-binding protein 1

1

3

High-throughput

0.479

High

1106389

NFAC2
Nuclear factor of activated T-cells, cytoplasmic 2

1

7

High-throughput

0.479

High

1115138

CUL4A
Cullin-4A

1

11

High-throughput

0.479

High

1133725

NFIX
Nuclear factor 1 X-type

1

1

High-throughput

0.479

High

1371086

ARHG2
Rho guanine nucleotide exchange factor 2

1

7

High-throughput

0.479

High

1387628

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

9

High-throughput

0.479

High

1459256

ZRAN1
Ubiquitin thioesterase ZRANB1

1

5

High-throughput

0.479

High

1218100

Q5VU62
TPM3 protein

1

8

High-throughput

0.470

High

959088

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

1

0

High-throughput

0.458

High

1415905

DDA1
DET1- and DDB1-associated protein 1

1

0

High-throughput

0.458

High

1057029

FMR1
Fragile X messenger ribonucleoprotein 1

1

5

High-throughput

0.457

High

1458930

ZO2
Tight junction protein 2

1

7

High-throughput

0.445

High

1461097

ITM2B
Integral membrane protein 2B

1

3

High-throughput

0.445

High

447891

TPM3
Tropomyosin alpha-3 chain

1

9

High-throughput

0.439

High

1351612

MIPT3
TRAF3-interacting protein 1

1

0

High-throughput

0.438

High

124126

SNP23
Synaptosomal-associated protein 23

1

0

Small-scale

0.324

High

1330699

BEND7
BEN domain-containing protein 7

2

0

High-throughput

0.316

High

65202

CX065
Uncharacterized protein CXorf65

1

0

High-throughput

0.249

Low

1454307

RELCH
RAB11-binding protein RELCH

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025