HitPredict

Interactor 1: MB3L2 (Q8NHZ7)
Methyl-CpG-binding domain protein 3-like 2 (MBD3-like protein 2)
Gene: MBD3L2

Interactor 2: HDAC2 (Q92769)
Histone deacetylase 2 (HD2) (EC 3.5.1.98) (Protein deacylase HDAC2) (EC 3.5.1.-)
Gene: HDAC2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.63	0.60	0.619

Property	Details
Experiments	33961781, 15701600
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 208 Hs			1 488
+	Hs
		328624 MBD3_HUMAN (16-208): 4.64e-87: 260: 30.93		HDAC2_HUMAN (1-488): 0: 707: 100.00
+	Mm
		936430 MBD3_MOUSE (16-208): 3.74e-88: 262: 31.44		HDAC2_MOUSE (1-488): 0: 704: 99.39
+	Hs
		1270493 MBD2_HUMAN (16-203): 4.85e-78: 241: 30.16		HDAC2_HUMAN (1-488): 0: 707: 100.00
+	Hs
		1263070 MB3L1_HUMAN (23-207): 2.17e-79: 237: 40.96		HDAC2_HUMAN (1-488): 0: 707: 100.00
+	Hs
		1038551 MB3L2_HUMAN (1-208): 5.51e-93: 272: 100.00		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Hs
		328550 MBD3_HUMAN (16-208): 4.64e-87: 260: 30.93		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Hs
		1038773 MBD2_HUMAN (16-203): 4.85e-78: 241: 30.16		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Hs
		1038575 MB3L1_HUMAN (23-207): 2.17e-79: 237: 40.96		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Dm
		1276539 Q9VHB7_DROME (41-194): 7.97e-60: 192: 27.22		HDAC1_DROME (5-472): 0: 653: 77.92