Protein: TB10B
TBC1 domain family member 10B (Rab27A-GAP-beta)

Gene: TB10B, TBC1D10B
Organism: Homo sapiens
Interactions: 99
UniProt ID: Q4KMP7

Gene Ontology (top 5):
GO:0005096 - GTPase activator activity
GO:0005829 - cytosol
GO:0005886 - plasma membrane
GO:0042147 - retrograde transport, endosome to Golgi
GO:0043087 - regulation of GTPase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1156105

ZYX
Zyxin

3

2

High-throughput

0.667

High

341069

DIRA3
GTP-binding protein Di-Ras3

1

12

High-throughput

0.618

High

374647

RASH
GTPase HRas

1

14

High-throughput

0.618

High

375570

RASK
GTPase KRas

1

19

High-throughput

0.618

High

601314

RHOQ
Rho-related GTP-binding protein RhoQ

1

20

High-throughput

0.618

High

953480

RAC3
Ras-related C3 botulinum toxin substrate 3

1

19

High-throughput

0.618

High

956320

RAB2A
Ras-related protein Rab-2A

1

12

High-throughput

0.618

High

978047

RHOB
Rho-related GTP-binding protein RhoB

1

20

High-throughput

0.618

High

988411

RAC1
Ras-related C3 botulinum toxin substrate 1

1

19

High-throughput

0.618

High

1144930

RAB35
Ras-related protein Rab-35

1

10

High-throughput

0.618

High

1195292

TB10B
TBC1 domain family member 10B

1

7

High-throughput

0.618

High

1195314

RHOJ
Rho-related GTP-binding protein RhoJ

1

20

High-throughput

0.618

High

1195316

RHOF
Rho-related GTP-binding protein RhoF

1

20

High-throughput

0.618

High

412035

NTRK1
High affinity nerve growth factor receptor

2

20

High-throughput

0.584

High

1121790

EIF3A
Eukaryotic translation initiation factor 3 subunit A

2

2

High-throughput

0.584

High

1195295

CCD70
Coiled-coil domain-containing protein 70

2

0

High-throughput

0.580

High

1195312

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

1

20

Small-scale

0.561

High

1195313

MLP3A
Microtubule-associated protein 1 light chain 3 alpha

1

20

Small-scale

0.561

High

1195309

RIOK1
Serine/threonine-protein kinase RIO1

1

2

High-throughput

0.536

High

250640

HNRPQ
Heterogeneous nuclear ribonucleoprotein Q

1

0

High-throughput

0.513

High

157452

CTRO
Citron Rho-interacting kinase

1

1

High-throughput

0.479

High

189599

STX7
Syntaxin-7

1

3

High-throughput

0.479

High

226053

STX6
Syntaxin-6

1

1

High-throughput

0.479

High

241868

PRKN
E3 ubiquitin-protein ligase parkin

1

5

High-throughput

0.479

High

400929

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

2

High-throughput

0.479

High

461554

HS90A
Heat shock protein HSP 90-alpha

1

3

High-throughput

0.479

High

463554

LYN
Tyrosine-protein kinase Lyn

1

3

High-throughput

0.479

High

540480

LAMP1
Lysosome-associated membrane glycoprotein 1

1

8

High-throughput

0.479

High

541526

FGFR1
Fibroblast growth factor receptor 1

1

20

High-throughput

0.479

High

556124

CADH1
Cadherin-1

1

4

High-throughput

0.479

High

642906

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

3

High-throughput

0.479

High

710279

EPHA2
Ephrin type-A receptor 2

1

16

High-throughput

0.479

High

710844

EPHB2
Ephrin type-B receptor 2

1

13

High-throughput

0.479

High

715611

MARCS
Myristoylated alanine-rich C-kinase substrate

1

2

High-throughput

0.479

High

729889

1433B
14-3-3 protein beta/alpha

1

20

High-throughput

0.479

High

845670

MUC18
Cell surface glycoprotein MUC18

1

3

High-throughput

0.479

High

884344

UBE2A
Ubiquitin-conjugating enzyme E2 A

1

1

High-throughput

0.479

High

914270

EFNA4
Ephrin-A4

1

3

High-throughput

0.479

High

934699

TERA
Transitional endoplasmic reticulum ATPase

1

2

High-throughput

0.479

High

966395

1433G
14-3-3 protein gamma

1

20

High-throughput

0.479

High

975065

ARF6
ADP-ribosylation factor 6

1

6

High-throughput

0.479

High

1004075

CXAR
Coxsackievirus and adenovirus receptor

1

2

High-throughput

0.479

High

1034253

ROR2
Tyrosine-protein kinase transmembrane receptor ROR2

1

20

High-throughput

0.479

High

1041098

CAV1
Caveolin-1

1

2

High-throughput

0.479

High

1049354

1433F
14-3-3 protein eta

1

20

High-throughput

0.479

High

1137742

TNIP1
TNFAIP3-interacting protein 1

1

3

High-throughput

0.479

High

1147340

EPHA7
Ephrin type-A receptor 7

1

14

High-throughput

0.479

High

1151524

TRIP6
Thyroid receptor-interacting protein 6

1

1

High-throughput

0.479

High

1156963

NTRK3
NT-3 growth factor receptor

1

19

High-throughput

0.479

High

1159672

OCLN
Occludin

1

2

High-throughput

0.479

High

1195294

LTOR1
Ragulator complex protein LAMTOR1

1

4

High-throughput

0.479

High

1195296

LMBRL
Protein LMBR1L

1

1

High-throughput

0.479

High

1195299

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

2

High-throughput

0.479

High

1195301

CXD3
Gap junction delta-3 protein

1

6

High-throughput

0.479

High

1195304

ASB11
Ankyrin repeat and SOCS box protein 11

1

2

High-throughput

0.479

High

1195311

ACE2
Angiotensin-converting enzyme 2

1

1

High-throughput

0.479

High

1195315

PKHA4
Pleckstrin homology domain-containing family A member 4

1

5

High-throughput

0.479

High

1195317

CISH
Cytokine-inducible SH2-containing protein

1

4

High-throughput

0.479

High

1195319

ZRAN1
Ubiquitin thioesterase ZRANB1

1

5

High-throughput

0.479

High

1195320

TBK1
Serine/threonine-protein kinase TBK1

1

2

High-throughput

0.479

High

1195321

LAMP3
Lysosome-associated membrane glycoprotein 3

1

8

High-throughput

0.479

High

141515

DDX3X
ATP-dependent RNA helicase DDX3X

1

0

Small-scale

0.458

High

692987

DPP4
Dipeptidyl peptidase 4

1

0

High-throughput

0.458

High

896543

VASP
Vasodilator-stimulated phosphoprotein

1

0

High-throughput

0.458

High

904798

MECP2
Methyl-CpG-binding protein 2

1

0

High-throughput

0.458

High

1117279

APR
Phorbol-12-myristate-13-acetate-induced protein 1

1

0

High-throughput

0.458

High

1123925

DYHC1
Cytoplasmic dynein 1 heavy chain 1

1

0

High-throughput

0.458

High

1195293

MIDN
Midnolin

1

0

High-throughput

0.458

High

1195300

DEN6A
Protein DENND6A

1

0

High-throughput

0.458

High

1195308

FMNL2
Formin-like protein 2

1

0

High-throughput

0.458

High

529912

TAU
Microtubule-associated protein tau

1

2

High-throughput

0.445

High

106046

APRIO
Alternative prion protein

1

3

High-throughput

0.437

High

181709

CTDSL
CTD small phosphatase-like protein

1

2

High-throughput

0.437

High

327285

ZFPL1
Zinc finger protein-like 1

1

1

High-throughput

0.437

High

372189

MYC
Myc proto-oncogene protein

1

4

High-throughput

0.437

High

406242

MYCN
N-myc proto-oncogene protein

1

4

High-throughput

0.437

High

419018

H2A1B
Histone H2A type 1-B/E

1

2

High-throughput

0.437

High

588841

RFA2
Replication protein A 32 kDa subunit

1

2

High-throughput

0.437

High

695617

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

2

High-throughput

0.437

High

768345

RFA3
Replication protein A 14 kDa subunit

1

2

High-throughput

0.437

High

1004646

RNF4
E3 ubiquitin-protein ligase RNF4

1

2

High-throughput

0.437

High

1141153

BRD3
Bromodomain-containing protein 3

1

3

High-throughput

0.437

High

1195297

TRI67
Tripartite motif-containing protein 67

1

7

High-throughput

0.437

High

1195298

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

1

High-throughput

0.437

High

1195306

CK052
Uncharacterized protein C11orf52

1

1

High-throughput

0.437

High

809659

RS19
Small ribosomal subunit protein eS19

1

0

High-throughput

0.426

High

1145227

RNPS1
RNA-binding protein with serine-rich domain 1

1

0

High-throughput

0.426

High

1195318

KCMF1
E3 ubiquitin-protein ligase KCMF1

1

0

High-throughput

0.426

High

1195305

UTP4
U3 small nucleolar RNA-associated protein 4 homolog

1

1

High-throughput

0.407

High

1195310

ZN692
Zinc finger protein 692

1

1

High-throughput

0.407

High

175895

SET1A
Histone-lysine N-methyltransferase SETD1A

1

0

High-throughput

0.249

Low

940659

ATP5I
ATP synthase F(0) complex subunit e, mitochondrial

1

0

High-throughput

0.249

Low

979759

H4
Histone H4

1

0

High-throughput

0.249

Low

756552

GALNS
N-acetylgalactosamine-6-sulfatase

1

0

High-throughput

0.232

Low

1195302

RYBP
RING1 and YY1-binding protein

1

0

High-throughput

0.232

Low

1195303

ZCH10
Zinc finger CCHC domain-containing protein 10

1

0

High-throughput

0.232

Low

1195307

EAF1
ELL-associated factor 1

1

0

High-throughput

0.232

Low

1195322

RRP7A
Ribosomal RNA-processing protein 7 homolog A

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025