HitPredict

Interactor 1: NLRP3 (Q8R4B8)
NACHT, LRR and PYD domains-containing protein 3 (EC 3.6.4.-) (Cold autoinflammatory syndrome 1 protein homolog) (Cryopyrin) (Mast cell maturation-associated-inducible protein 1) (PYRIN-containing APAF1-like protein 1)
Gene: NLRP3

Interactor 2: ASC (Q9EPB4)
Apoptosis-associated speck-like protein containing a CARD (mASC) (PYD and CARD domain-containing protein)
Gene: Pycard

Species: Mus musculus

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.94 1.00 0.971

The method score is based on:

Property Details
Experiments 36063115, 36600050, 33931568, 34615873, 33460751, 23143333, 17907925, 24185614, 26416893, 27993998, 25605870, 34589402
Identification Methods affinity chromatography technology, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, proximity ligation assay
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains PYRIN~PYRIN
Common GO terms GO:0000139 - Golgi membrane
GO:0002221 - pattern recognition receptor signaling pathway
GO:0005576 - extracellular region
GO:0005634 - nucleus
GO:0005737 - cytoplasm
and 18 others

more...
Homologous interactions 16

Homologous interactions

Color coding for hit scores

1 1033
Mm

1 193
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Last updated: 15 Jul 2024