Protein: MYO5A
Unconventional myosin-Va (Dilute myosin heavy chain, non-muscle) (Myosin heavy chain 12) (Myosin-12) (Myoxin)

Gene: MYO5A
Organism: Homo sapiens
Interactions: 207
UniProt ID: Q9Y4I1

Gene Ontology (top 5):
GO:0000146 - microfilament motor activity
GO:0001726 - ruffle
GO:0003723 - RNA binding
GO:0005516 - calmodulin binding
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

534006

MLRV
Myosin regulatory light chain 2, ventricular/cardiac muscle isoform

2

16

High-throughput

0.811

High

169171

ML12B
Myosin regulatory light chain 12B

2

16

High-throughput

0.776

High

902308

RB27A
Ras-related protein Rab-27A

2

16

Small-scale

0.768

High

1395236

LRIQ1
Leucine-rich repeat- and IQ domain-containing protein 1

2

1

High-throughput

0.726

High

123886

MYO1C
Unconventional myosin-Ic

1

19

High-throughput

0.691

High

773100

MYH9
Myosin-9

1

16

High-throughput

0.691

High

863043

IQGA1
Ras GTPase-activating-like protein IQGAP1

1

8

High-throughput

0.691

High

993929

TNNC1
Troponin C, slow skeletal and cardiac muscles

1

14

High-throughput

0.691

High

1365627

MY18A
Unconventional myosin-XVIIIa

1

18

High-throughput

0.691

High

1392705

MYO19
Unconventional myosin-XIX

1

19

High-throughput

0.691

High

1447572

MYO5C
Unconventional myosin-Vc

1

18

High-throughput

0.691

High

230475

CREB3
Cyclic AMP-responsive element-binding protein 3

4

1

High-throughput

0.691

High

1414857

MELPH
Melanophilin

3

3

Small-scale

0.678

High

991787

DYL1
Dynein light chain 1, cytoplasmic

3

2

Small-scale

0.674

High

1390766

DYL2
Dynein light chain 2, cytoplasmic

3

2

Small-scale

0.669

High

647456

SCP2
Sterol carrier protein 2

3

1

High-throughput

0.667

High

828476

PEX19
Peroxisomal biogenesis factor 19

3

3

High-throughput

0.667

High

1389824

DTBP1
Dysbindin

3

1

High-throughput

0.667

High

1447494

ANLN
Anillin

3

5

High-throughput

0.656

High

397312

ESR1
Estrogen receptor

3

14

High-throughput

0.650

High

630451

RAB3A
Ras-related protein Rab-3A

1

13

Small-scale

0.647

High

273734

PP6R2
Serine/threonine-protein phosphatase 6 regulatory subunit 2

2

5

High-throughput

0.628

High

277479

AVIL
Advillin

2

8

High-throughput

0.628

High

749825

CADH5
Cadherin-5

2

4

High-throughput

0.628

High

1160810

DREB
Drebrin

2

4

High-throughput

0.628

High

1421039

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

2

2

High-throughput

0.628

High

1452693

TMOD3
Tropomodulin-3

2

8

High-throughput

0.628

High

1453570

TMOD4
Tropomodulin-4

2

8

High-throughput

0.628

High

126892

RHOD
Rho-related GTP-binding protein RhoD

1

6

High-throughput

0.618

High

318926

RHBT1
Rho-related BTB domain-containing protein 1

1

14

High-throughput

0.618

High

601517

RHOQ
Rho-related GTP-binding protein RhoQ

1

3

High-throughput

0.618

High

630677

RAB3B
Ras-related protein Rab-3B

1

13

High-throughput

0.618

High

631042

RAB4A
Ras-related protein Rab-4A

1

9

High-throughput

0.618

High

902162

RAB9A
Ras-related protein Rab-9A

1

15

High-throughput

0.618

High

956556

RAB2A
Ras-related protein Rab-2A

1

8

High-throughput

0.618

High

962867

RND3
Rho-related GTP-binding protein RhoE

1

9

High-throughput

0.618

High

976691

RB11A
Ras-related protein Rab-11A

1

9

High-throughput

0.618

High

993397

ACTG
Actin, cytoplasmic 2

1

11

High-throughput

0.618

High

1028918

SPTB2
Spectrin beta chain, non-erythrocytic 1

1

12

High-throughput

0.618

High

1145193

RAB35
Ras-related protein Rab-35

1

10

High-throughput

0.618

High

1151947

RHOH
Rho-related GTP-binding protein RhoH

1

4

High-throughput

0.618

High

1271065

RHOU
Rho-related GTP-binding protein RhoU

1

12

High-throughput

0.618

High

1396666

RHOV
Rho-related GTP-binding protein RhoV

1

6

High-throughput

0.618

High

1419441

RHBT2
Rho-related BTB domain-containing protein 2

1

20

High-throughput

0.618

High

1438265

RHOF
Rho-related GTP-binding protein RhoF

1

6

High-throughput

0.618

High

1490776

NINL
Ninein-like protein

1

15

High-throughput

0.618

High

1491414

MYO5A
Unconventional myosin-Va

1

17

High-throughput

0.618

High

1458598

DKK3
Dickkopf-related protein 3

3

3

High-throughput

0.604

High

1406440

FEZ1
Fasciculation and elongation protein zeta-1

2

0

High-throughput

0.602

High

373602

MYC
Myc proto-oncogene protein

3

3

High-throughput

0.585

High

279077

TRIM3
Tripartite motif-containing protein 3

2

7

Small-scale

0.584

High

387159

TNNC2
Troponin C, skeletal muscle

1

16

High-throughput

0.575

High

177419

ARHGB
Rho guanine nucleotide exchange factor 11

2

6

High-throughput

0.571

High

1143114

KPCD1
Serine/threonine-protein kinase D1

2

13

High-throughput

0.571

High

1389639

SAAL1
Protein SAAL1

2

2

High-throughput

0.549

High

169286

CASQ2
Calsequestrin-2

1

2

High-throughput

0.536

High

277442

TP4A3
Protein tyrosine phosphatase type IVA 3

1

6

High-throughput

0.536

High

277974

SH3L1
Adapter SH3BGRL

1

3

High-throughput

0.536

High

354047

CX001
Putative transmembrane protein CXorf1

1

2

High-throughput

0.536

High

447621

NPM
Nucleophosmin

1

2

High-throughput

0.536

High

530656

TAU
Microtubule-associated protein tau

1

7

High-throughput

0.536

High

637806

FLNA
Filamin-A

1

11

High-throughput

0.536

High

668087

CDK2
Cyclin-dependent kinase 2

1

11

High-throughput

0.536

High

866885

CAZA2
F-actin-capping protein subunit alpha-2

1

7

High-throughput

0.536

High

911963

JAK3
Tyrosine-protein kinase JAK3

1

8

High-throughput

0.536

High

968496

PP1B
Serine/threonine-protein phosphatase PP1-beta catalytic subunit

1

10

High-throughput

0.536

High

984037

RBX1
E3 ubiquitin-protein ligase RBX1

1

3

High-throughput

0.536

High

1030718

ANK2
Ankyrin-2

1

3

High-throughput

0.536

High

1092844

MALL
MAL-like protein

1

1

High-throughput

0.536

High

1095965

EI2BE
Translation initiation factor eIF2B subunit epsilon

1

3

High-throughput

0.536

High

1097179

MK07
Mitogen-activated protein kinase 7

1

5

High-throughput

0.536

High

1119724

CDK13
Cyclin-dependent kinase 13

1

14

High-throughput

0.536

High

1124767

SRC8
Src substrate cortactin

1

6

High-throughput

0.536

High

1153030

MYLK
Myosin light chain kinase, smooth muscle

1

15

High-throughput

0.536

High

1243077

PKN3
Serine/threonine-protein kinase N3

1

5

High-throughput

0.536

High

1310821

CUL9
Cullin-9

1

3

High-throughput

0.536

High

1311668

KIBRA
Protein KIBRA

1

7

High-throughput

0.536

High

1325473

SYNPO
Synaptopodin

1

6

High-throughput

0.536

High

1327852

ARRD1
Arrestin domain-containing protein 1

1

7

High-throughput

0.536

High

1352236

TBCK
TBC domain-containing protein kinase-like protein

1

5

High-throughput

0.536

High

1361644

SSH1
Protein phosphatase Slingshot homolog 1

1

5

High-throughput

0.536

High

1382558

TRI52
E3 ubiquitin-protein ligase TRIM52

1

4

High-throughput

0.536

High

1383522

PBIP1
Pre-B-cell leukemia transcription factor-interacting protein 1

1

13

High-throughput

0.536

High

1397267

LURA1
Leucine rich adaptor protein 1

1

1

High-throughput

0.536

High

1401010

PSKH2
Serine/threonine-protein kinase H2

1

6

High-throughput

0.536

High

1447741

PDLI7
PDZ and LIM domain protein 7

1

6

High-throughput

0.536

High

1459762

LIMA1
LIM domain and actin-binding protein 1

1

4

High-throughput

0.536

High

1462597

TRAK1
Trafficking kinesin-binding protein 1

1

16

High-throughput

0.536

High

1491417

RPKL1
Ribosomal protein S6 kinase-like 1

1

10

High-throughput

0.536

High

540975

ERG
Transcriptional regulator ERG

1

0

High-throughput

0.518

High

964088

COPZ1
Coatomer subunit zeta-1

1

0

High-throughput

0.513

High

750028

KINH
Kinesin-1 heavy chain

1

2

Small-scale

0.501

High

1371802

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

10

High-throughput

0.501

High

1490786

RP3A
Rabphilin-3A

1

3

Small-scale

0.501

High

317103

DPM2
Dolichol phosphate-mannose biosynthesis regulatory protein

1

2

High-throughput

0.489

High

1009633

CXCL6
C-X-C motif chemokine 6

1

2

High-throughput

0.489

High

1093789

GAGE5
G antigen 5

1

2

High-throughput

0.489

High

1105598

OS9
Protein OS-9

1

2

High-throughput

0.489

High

1290247

FHI2B
FHF complex subunit HOOK-interacting protein 2B

1

2

High-throughput

0.489

High

1349004

ZCH10
Zinc finger CCHC domain-containing protein 10

1

1

High-throughput

0.489

High

1459925

I20RA
Interleukin-20 receptor subunit alpha

1

1

High-throughput

0.489

High

1461439

PNMA2
Paraneoplastic antigen Ma2

1

7

High-throughput

0.489

High

1408564

AKAP9
A-kinase anchor protein 9

1

17

High-throughput

0.481

High

1428230

NDEL1
Nuclear distribution protein nudE-like 1

1

8

High-throughput

0.481

High

1397008

BMF
Bcl-2-modifying factor

1

0

Small-scale

0.480

High

189951

STX7
Syntaxin-7

1

1

High-throughput

0.479

High

252932

EXOC3
Exocyst complex component 3

1

2

Small-scale

0.479

High

323625

TRI37
E3 ubiquitin-protein ligase TRIM37

1

16

High-throughput

0.479

High

346554

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

2

High-throughput

0.479

High

370823

FOS
Protein c-Fos

1

5

High-throughput

0.479

High

378212

TNFA
Tumor necrosis factor

1

2

High-throughput

0.479

High

412873

NTRK1
High affinity nerve growth factor receptor

1

7

High-throughput

0.479

High

425687

ISG15
Ubiquitin-like protein ISG15

1

6

High-throughput

0.479

High

440259

LCK
Tyrosine-protein kinase Lck

1

4

High-throughput

0.479

High

459817

PROF1
Profilin-1

1

1

High-throughput

0.479

High

520482

ANDR
Androgen receptor

1

14

High-throughput

0.479

High

540773

LAMP1
Lysosome-associated membrane glycoprotein 1

1

2

High-throughput

0.479

High

562514

LAMP2
Lysosome-associated membrane glycoprotein 2

1

2

High-throughput

0.479

High

630111

BTF3
Transcription factor BTF3

1

4

High-throughput

0.479

High

646970

PUR6
Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase

1

1

High-throughput

0.479

High

838475

GRIA1
Glutamate receptor 1

1

4

Small-scale

0.479

High

840995

ABL2
Tyrosine-protein kinase ABL2

1

4

High-throughput

0.479

High

898038

CDK9
Cyclin-dependent kinase 9

1

16

High-throughput

0.479

High

908879

NEK2
Serine/threonine-protein kinase Nek2

1

14

Small-scale

0.479

High

930096

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

1

2

High-throughput

0.479

High

1036023

KIF23
Kinesin-like protein KIF23

1

4

High-throughput

0.479

High

1108315

SQSTM
Sequestosome-1

1

1

High-throughput

0.479

High

1125274

TRI25
E3 ubiquitin/ISG15 ligase TRIM25

1

4

High-throughput

0.479

High

1138197

TNIP1
TNFAIP3-interacting protein 1

1

15

High-throughput

0.479

High

1141101

KIF14
Kinesin-like protein KIF14

1

5

High-throughput

0.479

High

1155945

EZH2
Histone-lysine N-methyltransferase EZH2

1

3

High-throughput

0.479

High

1197610

PAN2
PAN2-PAN3 deadenylation complex catalytic subunit PAN2

1

11

High-throughput

0.479

High

1227773

A16L1
Autophagy-related protein 16-1

1

2

High-throughput

0.479

High

1256247

TRI67
Tripartite motif-containing protein 67

1

15

High-throughput

0.479

High

1290859

ZCH18
Zinc finger CCCH domain-containing protein 18

1

5

High-throughput

0.479

High

1313008

S35F2
Solute carrier family 35 member F2

1

1

Small-scale

0.479

High

1328737

FHI1B
FHF complex subunit HOOK-interacting protein 1B

1

2

High-throughput

0.479

High

1330993

CGAS
Cyclic GMP-AMP synthase

1

1

High-throughput

0.479

High

1347265

EXOC6
Exocyst complex component 6

1

2

Small-scale

0.479

High

1349791

FBX25
F-box only protein 25

1

6

High-throughput

0.479

High

1360854

ASB11
Ankyrin repeat and SOCS box protein 11

1

4

High-throughput

0.479

High

1364731

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

3

High-throughput

0.479

High

1380289

FBXW7
F-box/WD repeat-containing protein 7

1

5

Small-scale

0.479

High

1382612

EXOC4
Exocyst complex component 4

1

1

Small-scale

0.479

High

1430658

CCDC8
Coiled-coil domain-containing protein 8

1

7

High-throughput

0.479

High

1433017

DNJC5
DnaJ homolog subfamily C member 5

1

1

High-throughput

0.479

High

1434326

PKHA4
Pleckstrin homology domain-containing family A member 4

1

14

High-throughput

0.479

High

1448262

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

3

High-throughput

0.479

High

1458569

HDAC6
Protein deacetylase HDAC6

1

9

High-throughput

0.479

High

1461863

CLC4E
C-type lectin domain family 4 member E

1

3

High-throughput

0.479

High

1462615

SHAN2
SH3 and multiple ankyrin repeat domains protein 2

1

7

Small-scale

0.479

High

1491115

PHOCN
MOB-like protein phocein

1

1

High-throughput

0.479

High

1491415

LOXL2
Lysyl oxidase homolog 2

1

1

High-throughput

0.479

High

169804

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

1

0

Small-scale

0.458

High

248165

NUPR1
Nuclear protein 1

1

0

High-throughput

0.458

High

294580

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.458

High

941313

IF6
Eukaryotic translation initiation factor 6

1

0

High-throughput

0.458

High

941993

PEX3
Peroxisomal biogenesis factor 3

1

0

High-throughput

0.458

High

1153956

SMAD2
Mothers against decapentaplegic homolog 2

1

0

High-throughput

0.458

High

1233609

LTOR1
Ragulator complex protein LAMTOR1

1

0

High-throughput

0.458

High

1247059

RICTR
Rapamycin-insensitive companion of mTOR

1

0

High-throughput

0.458

High

1331926

DTX3
Probable E3 ubiquitin-protein ligase DTX3

1

0

Small-scale

0.458

High

1448593

DISC1
Disrupted in schizophrenia 1 protein

1

1

High-throughput

0.457

High

58976

PIPSL
Putative PIP5K1A and PSMD4-like protein

1

3

High-throughput

0.445

High

288830

NPM3
Nucleoplasmin-3

1

2

High-throughput

0.445

High

324243

CE152
Centrosomal protein of 152 kDa

1

15

High-throughput

0.445

High

351193

ECD
Protein ecdysoneless homolog

1

2

High-throughput

0.445

High

564608

CFTR
Cystic fibrosis transmembrane conductance regulator

1

12

High-throughput

0.445

High

728631

AKT2
RAC-beta serine/threonine-protein kinase

1

5

Small-scale

0.445

High

839116

PK3CA
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

1

3

High-throughput

0.445

High

1288954

RIMS1
Regulating synaptic membrane exocytosis protein 1

1

6

High-throughput

0.445

High

1332543

POC5
Centrosomal protein POC5

1

1

High-throughput

0.445

High

1385152

MOAP1
Modulator of apoptosis 1

1

7

High-throughput

0.445

High

1398420

CEP63
Centrosomal protein of 63 kDa

1

18

High-throughput

0.445

High

1400206

SYGP1
Ras/Rap GTPase-activating protein SynGAP

1

8

High-throughput

0.445

High

1402165

S22AC
Solute carrier family 22 member 12

1

1

High-throughput

0.445

High

1402935

CK5P2
CDK5 regulatory subunit-associated protein 2

1

19

High-throughput

0.445

High

1420780

ZDHC5
Palmitoyltransferase ZDHHC5

1

2

High-throughput

0.445

High

1462558

NAC2
Sodium/calcium exchanger 2

1

3

High-throughput

0.445

High

1490599

ITM2B
Integral membrane protein 2B

1

3

High-throughput

0.445

High

1491081

RBMX2
RNA-binding motif protein, X-linked 2

1

3

High-throughput

0.445

High

474402

NFIC
Nuclear factor 1 C-type

1

1

High-throughput

0.437

High

838518

GRIA2
Glutamate receptor 2

1

4

Small-scale

0.437

High

1250220

LRC31
Leucine-rich repeat-containing protein 31

1

6

High-throughput

0.437

High

1360968

CLC4D
C-type lectin domain family 4 member D

1

3

High-throughput

0.437

High

1367679

ESR2
Estrogen receptor beta

1

14

High-throughput

0.437

High

1429975

RNF38
E3 ubiquitin-protein ligase RNF38

1

6

Small-scale

0.437

High

1461730

HECD1
E3 ubiquitin-protein ligase HECTD1

1

2

High-throughput

0.437

High

1462791

LAMP3
Lysosome-associated membrane glycoprotein 3

1

2

High-throughput

0.437

High

213286

CP110
Centriolar coiled-coil protein of 110 kDa

1

0

High-throughput

0.426

High

239262

ZNRD2
Protein ZNRD2

1

0

High-throughput

0.426

High

935341

TERA
Transitional endoplasmic reticulum ATPase

1

0

High-throughput

0.426

High

1251213

ZNT10
Calcium/manganese antiporter SLC30A10

1

0

High-throughput

0.426

High

1317029

FAM9B
Protein FAM9B

1

0

High-throughput

0.426

High

1351620

MIPT3
TRAF3-interacting protein 1

1

1

High-throughput

0.417

High

51522

FSD2
Fibronectin type III and SPRY domain-containing protein 2

1

9

High-throughput

0.407

High

255320

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

3

High-throughput

0.407

High

1103473

CTBP1
C-terminal-binding protein 1

1

2

High-throughput

0.407

High

1395438

NEUL4
Neuralized-like protein 4

1

3

High-throughput

0.407

High

1405546

ZBT18
Zinc finger and BTB domain-containing protein 18

1

2

High-throughput

0.407

High

1491416

EID1
EP300-interacting inhibitor of differentiation 1

2

0

High-throughput

0.328

High

154405

DLGP1
Disks large-associated protein 1

1

0

Small-scale

0.261

Low

106916

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

1277028

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.249

Low

1449541

INKA2
PAK4-inhibitor INKA2

1

0

Small-scale

0.249

Low

1357258

S38A5
Sodium-coupled neutral amino acid transporter 5

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025