HitPredict

Interactor 1: WWP2 (O00308)
NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 2.3.2.26) (Atrophin-1-interacting protein 2) (AIP2) (HECT-type E3 ubiquitin transferase WWP2) (WW domain-containing protein 2)
Gene: WWP2

Interactor 2: M3K7 (O43318)
Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta-activated kinase 1)
Gene: MAP3K7

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0010629 - negative regulation of gene expression
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 870 Hs			1 606
+	Hs
		201397 ITCH_HUMAN (1-870): 0: 902: 54.26		M3K7_HUMAN (1-606): 0: 574: 100.00
+	Hs
		1052834 NED4L_HUMAN (5-867): 0: 785: 32.17		FAK2_HUMAN (31-603): 1.5e-116: 372: 18.58
+	Hs
		125761 WWP2_HUMAN (1-870): 0: 982: 100.00		M3K20_HUMAN (27-287): 2.26e-39: 156: 36.16
+	Hs
		808126 NEDD4_HUMAN (90-867): 0: 731: 35.94		FAK2_HUMAN (31-603): 1.5e-116: 372: 18.58
+	Hs
		808060 NEDD4_HUMAN (90-867): 0: 731: 35.94		EPHA5_HUMAN (16-325): 4.76e-100: 328: 28.27
+	Hs
		1299653 NED4L_HUMAN (5-867): 0: 785: 32.17		M3K20_HUMAN (27-287): 2.26e-39: 156: 36.16
+	Hs
		972468 SMUF1_HUMAN (1-385): 1.35e-45: 177: 17.77		M3K10_HUMAN (29-282): 2.43e-45: 174: 38.89
+	Hs
		945781 SMUF1_HUMAN (1-385): 1.35e-45: 177: 17.77		M3K9_HUMAN (3-285): 4.42e-39: 155: 36.55