Protein: PTPRD
Receptor-type tyrosine-protein phosphatase delta (Protein-tyrosine phosphatase delta) (R-PTP-delta) (EC 3.1.3.48)

Gene: PTPRD
Organism: Homo sapiens
Interactions: 137
UniProt ID: P23468

Gene Ontology (top 5):
GO:0004725 - protein tyrosine phosphatase activity
GO:0005001 - transmembrane receptor protein tyrosine phosphatase activity
GO:0005102 - signaling receptor binding
GO:0005886 - plasma membrane
GO:0006796 - phosphate-containing compound metabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

262208

SCN2B
Sodium channel regulatory subunit beta-2

4

8

High-throughput

0.892

High

271594

ICOSL
ICOS ligand

2

9

High-throughput

0.811

High

658879

CD83
CD83 antigen

2

1

High-throughput

0.811

High

658896

LRRN1
Leucine-rich repeat neuronal protein 1

2

4

High-throughput

0.811

High

658900

LIGO2
Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 2

2

5

High-throughput

0.811

High

658912

LIRB4
Leukocyte immunoglobulin-like receptor subfamily B member 4

2

5

High-throughput

0.811

High

658881

PTPRS
Receptor-type tyrosine-protein phosphatase S

2

17

Small-scale

0.800

High

212897

LRRT2
Leucine-rich repeat transmembrane neuronal protein 2

2

7

High-throughput

0.789

High

658852

IL2RG
Cytokine receptor common subunit gamma

2

18

High-throughput

0.789

High

658880

LIPA1
Liprin-alpha-1

2

11

Small-scale

0.786

High

362779

EGFR
Epidermal growth factor receptor

2

20

High-throughput

0.783

High

169953

AURKA
Aurora kinase A

1

0

Small-scale

0.722

High

658924

SLIK1
SLIT and NTRK-like protein 1

1

3

Small-scale

0.710

High

658877

HUNK
Hormonally up-regulated neu tumor-associated kinase

1

4

High-throughput

0.698

High

658851

EPHA8
Ephrin type-A receptor 8

1

20

Small-scale

0.692

High

658869

KC1D
Casein kinase I isoform delta

1

3

Small-scale

0.692

High

658871

KC1E
Casein kinase I isoform epsilon

1

3

Small-scale

0.692

High

658872

BMX
Cytoplasmic tyrosine-protein kinase BMX

1

20

Small-scale

0.692

High

658873

NEK2
Serine/threonine-protein kinase Nek2

1

4

Small-scale

0.692

High

658899

MARK2
Serine/threonine-protein kinase MARK2

1

2

Small-scale

0.692

High

127637

TR10A
Tumor necrosis factor receptor superfamily member 10A

1

2

High-throughput

0.691

High

276208

LRRN2
Leucine-rich repeat neuronal protein 2

1

6

High-throughput

0.691

High

440371

FYN
Tyrosine-protein kinase Fyn

1

20

High-throughput

0.691

High

488723

FURIN
Furin

1

2

High-throughput

0.691

High

658849

IL3RA
Interleukin-3 receptor subunit alpha

1

18

High-throughput

0.691

High

658853

RYK
Tyrosine-protein kinase RYK

1

20

High-throughput

0.691

High

658856

TGFR2
TGF-beta receptor type-2

1

6

High-throughput

0.691

High

658861

KI2L1
Killer cell immunoglobulin-like receptor 2DL1

1

2

High-throughput

0.691

High

658889

TIGIT
T-cell immunoreceptor with Ig and ITIM domains

1

1

High-throughput

0.691

High

658902

MILR1
Allergin-1

1

8

High-throughput

0.691

High

658938

NLGN3
Neuroligin-3

1

4

High-throughput

0.691

High

658862

LPAR6
Lysophosphatidic acid receptor 6

3

7

High-throughput

0.667

High

283656

GPC4
Glypican-4

1

8

Small-scale

0.647

High

658846

OMGP
Oligodendrocyte-myelin glycoprotein

1

6

Small-scale

0.647

High

658860

MATK
Megakaryocyte-associated tyrosine-protein kinase

1

20

Small-scale

0.647

High

658934

IL1AP
Interleukin-1 receptor accessory protein

1

10

Small-scale

0.647

High

658905

PIANP
PILR alpha-associated neural protein

2

1

High-throughput

0.628

High

658906

IZUM1
Izumo sperm-egg fusion protein 1

2

1

High-throughput

0.628

High

658908

PCD20
Protocadherin-20

2

20

High-throughput

0.628

High

658926

LITAF
Lipopolysaccharide-induced tumor necrosis factor-alpha factor

2

1

High-throughput

0.628

High

658936

PCDBG
Protocadherin beta-16

2

19

High-throughput

0.628

High

658945

PCDGG
Protocadherin gamma-B4

2

19

High-throughput

0.628

High

271614

LIPA3
Liprin-alpha-3

1

11

Small-scale

0.621

High

276361

LIPA2
Liprin-alpha-2

1

13

Small-scale

0.621

High

658874

PLK1
Serine/threonine-protein kinase PLK1

1

2

Small-scale

0.619

High

658888

SMTL2
Smoothelin-like protein 2

1

2

Small-scale

0.619

High

658923

TSSK2
Testis-specific serine/threonine-protein kinase 2

1

3

Small-scale

0.619

High

658925

NEK1
Serine/threonine-protein kinase Nek1

1

9

Small-scale

0.619

High

658933

NEK6
Serine/threonine-protein kinase Nek6

1

3

Small-scale

0.619

High

658935

PAK6
Serine/threonine-protein kinase PAK 6

1

1

Small-scale

0.619

High

658943

TBK1
Serine/threonine-protein kinase TBK1

1

9

Small-scale

0.619

High

658850

TPP2
Tripeptidyl-peptidase 2

1

2

High-throughput

0.618

High

658895

POTEA
POTE ankyrin domain family member A

1

4

High-throughput

0.618

High

299515

TRIO
Triple functional domain protein

1

2

High-throughput

0.618

High

658855

ACVL1
Activin receptor type-1-like

1

6

Small-scale

0.618

High

658939

IRPL1
Interleukin-1 receptor accessory protein-like 1

1

15

Small-scale

0.618

High

658859

PMEL
Melanocyte protein PMEL

2

0

High-throughput

0.602

High

658911

I17RD
Interleukin-17 receptor D

2

0

High-throughput

0.602

High

658931

ABCG8
ATP-binding cassette sub-family G member 8

2

0

High-throughput

0.602

High

658909

LRC52
Leucine-rich repeat-containing protein 52

1

4

High-throughput

0.575

High

658904

RIMS1
Regulating synaptic membrane exocytosis protein 1

1

0

High-throughput

0.546

High

658845

PTPRD
Receptor-type tyrosine-protein phosphatase delta

1

16

Small-scale

0.545

High

658857

GRIK1
Glutamate receptor ionotropic, kainate 1

1

4

High-throughput

0.541

High

658865

MTR1A
Melatonin receptor type 1A

1

3

High-throughput

0.541

High

658870

MTR1B
Melatonin receptor type 1B

1

3

High-throughput

0.541

High

658854

IRS1
Insulin receptor substrate 1

1

6

Small-scale

0.536

High

658914

DDX54
ATP-dependent RNA helicase DDX54

1

2

Small-scale

0.536

High

165903

FFAR1
Free fatty acid receptor 1

1

4

High-throughput

0.536

High

186881

GPR37
Prosaposin receptor GPR37

1

5

High-throughput

0.536

High

221445

OX2R
Orexin receptor type 2

1

2

High-throughput

0.536

High

376593

TGFA
Protransforming growth factor alpha [Cleaved into: Transforming growth factor alpha

1

1

High-throughput

0.536

High

480705

LEG1
Galectin-1

1

20

High-throughput

0.536

High

640489

TA2R
Thromboxane A2 receptor

1

5

High-throughput

0.536

High

647459

UD11
UDP-glucuronosyltransferase 1A1

1

1

High-throughput

0.536

High

658863

RL28
Large ribosomal subunit protein eL28

1

3

High-throughput

0.536

High

658864

V1BR
Vasopressin V1b receptor

1

3

High-throughput

0.536

High

658883

KCNC3
Voltage-gated potassium channel KCNC3

1

4

High-throughput

0.536

High

658892

LTOR1
Ragulator complex protein LAMTOR1

1

2

High-throughput

0.536

High

658897

SO4C1
Solute carrier organic anion transporter family member 4C1

1

1

High-throughput

0.536

High

658898

RHG36
Rho GTPase-activating protein 36

1

1

High-throughput

0.536

High

658903

T150A
Transmembrane protein 150A

1

1

High-throughput

0.536

High

658919

TR19L
Tumor necrosis factor receptor superfamily member 19L

1

3

High-throughput

0.536

High

658921

MRAP2
Melanocortin-2 receptor accessory protein 2

1

2

High-throughput

0.536

High

658922

OPALI
Opalin

1

1

High-throughput

0.536

High

658940

MARH2
E3 ubiquitin-protein ligase MARCHF2

1

7

High-throughput

0.536

High

658944

I20RA
Interleukin-20 receptor subunit alpha

1

11

High-throughput

0.536

High

658946

PCDB6
Protocadherin beta-6

1

19

High-throughput

0.536

High

658947

PCDB1
Protocadherin beta-1

1

18

High-throughput

0.536

High

658948

PCDG6
Protocadherin gamma-A6

1

20

High-throughput

0.536

High

540809

ERG
Transcriptional regulator ERG

1

0

High-throughput

0.518

High

658866

KCNJ6
G protein-activated inward rectifier potassium channel 2

1

0

High-throughput

0.518

High

658893

AR26L
Putative ankyrin repeat domain-containing protein 26-like protein

1

7

High-throughput

0.514

High

190308

COPT1
High affinity copper uptake protein 1

1

0

High-throughput

0.513

High

336523

PIGN
GPI ethanolamine phosphate transferase 1

1

0

High-throughput

0.513

High

658890

TM52B
Transmembrane protein 52B

1

0

High-throughput

0.513

High

658901

KCNKI
Potassium channel subfamily K member 18

1

0

High-throughput

0.513

High

658907

MCLN2
Mucolipin-2

1

0

High-throughput

0.513

High

213510

MTSS1
Protein MTSS 1

1

2

Small-scale

0.506

High

328423

SCEL
Sciellin

1

1

Small-scale

0.501

High

159151

ABLM1
Actin-binding LIM protein 1

1

7

Small-scale

0.489

High

658876

ECHB
Trifunctional enzyme subunit beta, mitochondrial

1

1

High-throughput

0.489

High

658894

NIPA3
Magnesium transporter NIPA3

1

4

High-throughput

0.489

High

658913

TPC2
Two pore channel protein 2

1

9

High-throughput

0.489

High

658915

RN133
E3 ubiquitin-protein ligase RNF133

1

8

High-throughput

0.489

High

658929

SE6L1
Seizure 6-like protein

1

4

High-throughput

0.489

High

658932

ZDH11
Palmitoyltransferase ZDHHC11

1

4

High-throughput

0.489

High

658937

CLDN1
Claudin domain-containing protein 1

1

2

High-throughput

0.489

High

555875

CADH1
Cadherin-1

1

20

Small-scale

0.479

High

658884

DSC3
Desmocollin-3

1

20

High-throughput

0.479

High

658928

ACE2
Angiotensin-converting enzyme 2

1

2

Small-scale

0.479

High

658891

PRRT3
Proline-rich transmembrane protein 3

1

2

High-throughput

0.470

High

658878

MDM2
E3 ubiquitin-protein ligase Mdm2

1

0

High-throughput

0.458

High

658916

Q8WW87
SCEL protein

1

1

Small-scale

0.457

High

658918

DDX17
Probable ATP-dependent RNA helicase DDX17

1

1

Small-scale

0.457

High

138450

BIN1
Myc box-dependent-interacting protein 1

1

9

High-throughput

0.457

High

254812

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

6

High-throughput

0.445

High

658848

ACKR3
Atypical chemokine receptor 3

1

6

High-throughput

0.445

High

658867

S6A12
Sodium- and chloride-dependent betaine transporter

1

6

High-throughput

0.445

High

658868

EAA4
Excitatory amino acid transporter 4

1

4

High-throughput

0.445

High

658882

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

7

High-throughput

0.445

High

658885

NTCP
Hepatic sodium/bile acid cotransporter

1

4

High-throughput

0.445

High

658886

T132D
Transmembrane protein 132D

1

1

Small-scale

0.439

High

658920

FERM2
Fermitin family homolog 2

1

0

High-throughput

0.438

High

105354

APRIO
Alternative prion protein

1

4

High-throughput

0.437

High

658927

Q9BXH2
STAT3

1

1

Small-scale

0.407

High

658875

RCAN1
Calcipressin-1

1

0

High-throughput

0.282

High

658917

RSPH1
Radial spoke head 1 homolog

1

0

High-throughput

0.282

High

658941

SLAI2
SLAIN motif-containing protein 2

1

0

Small-scale

0.279

Low

49436

TM223
Transmembrane protein 223

1

0

High-throughput

0.279

Low

51527

PL8L1
PLAC8-like protein 1

1

0

High-throughput

0.279

Low

658847

IL32
Interleukin-32

1

0

High-throughput

0.279

Low

658858

ECHA
Trifunctional enzyme subunit alpha, mitochondrial

1

0

High-throughput

0.279

Low

658910

SAXO5
Stabilizer of axonemal microtubules 5

1

0

High-throughput

0.279

Low

658930

STMN4
Stathmin-4

1

0

High-throughput

0.279

Low

658942

COPG2
Coatomer subunit gamma-2

1

0

High-throughput

0.279

Low

658887

SF3B3
Splicing factor 3B subunit 3

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025