HitPredict

Interactor 1: WWP2 (O00308)
NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 2.3.2.26) (Atrophin-1-interacting protein 2) (AIP2) (HECT-type E3 ubiquitin transferase WWP2) (WW domain-containing protein 2)
Gene: WWP2

Interactor 2: TOM1 (O60784)
Target of Myb1 membrane trafficking protein (Target of Myb protein 1)
Gene: TOM1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	35331737
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0016020 - membrane GO:0070062 - extracellular exosome
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 870 Hs			1 492
+	Hs
		125533 WWP2_HUMAN (1-870): 0: 982: 100.00		TM1L2_HUMAN (1-492): 2.32e-147: 432: 61.45
+	Hs
		125613 WWP2_HUMAN (1-870): 0: 982: 100.00		STAM1_HUMAN (1-477): 6.09e-92: 291: 19.27
+	Hs
		241153 NEDD4_HUMAN (90-867): 0: 731: 35.94		TOM1_HUMAN (1-492): 5.19e-178: 510: 100.00
+	Hs
		125001 WWP2_HUMAN (1-870): 0: 982: 100.00		HGS_HUMAN (10-465): 5.12e-76: 255: 17.90
+	Hs
		1270607 ITCH_HUMAN (1-870): 0: 902: 54.26		STAM1_HUMAN (1-477): 6.09e-92: 291: 19.27
+	Hs
		1294876 ITCH_HUMAN (1-870): 0: 902: 54.26		GGA3_HUMAN (12-476): 3.9e-84: 276: 21.28
+	Hs
		808171 NEDD4_HUMAN (90-867): 0: 731: 35.94		TM1L2_HUMAN (1-492): 2.32e-147: 432: 61.45
+	Hs
		160143 ITCH_HUMAN (1-870): 0: 902: 54.26		HGS_HUMAN (10-465): 5.12e-76: 255: 17.90
+	Hs
		277114 ITCH_HUMAN (1-870): 0: 902: 54.26		STAM2_HUMAN (1-454): 3.15e-74: 245: 19.61
+	Hs
		160160 NED4L_HUMAN (5-867): 0: 785: 32.17		HGS_HUMAN (10-465): 5.12e-76: 255: 17.90
+	Hs
		808298 NEDD4_HUMAN (90-867): 0: 731: 35.94		GGA3_HUMAN (12-476): 3.9e-84: 276: 21.28
+	Hs
		159925 NEDD4_HUMAN (90-867): 0: 731: 35.94		HGS_HUMAN (10-465): 5.12e-76: 255: 17.90
+	Hs
		241199 SMUF1_HUMAN (1-385): 1.35e-45: 177: 17.77		TOM1_HUMAN (1-492): 5.19e-178: 510: 100.00
+	Hs
		1173029 SMUF1_HUMAN (1-385): 1.35e-45: 177: 17.77		TM1L2_HUMAN (1-492): 2.32e-147: 432: 61.45