Protein: KCNK1
Potassium channel subfamily K member 1 (Inward rectifying potassium channel protein TWIK-1) (Potassium channel K2P1) (Potassium channel KCNO1)

Gene: KCNK1
Organism: Homo sapiens
Interactions: 79
UniProt ID: O00180

Gene Ontology (top 5):
GO:0005242 - inward rectifier potassium channel activity
GO:0005267 - potassium channel activity
GO:0005272 - sodium channel activity
GO:0005886 - plasma membrane
GO:0006813 - potassium ion transport

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

124987

KCNK1
Potassium channel subfamily K member 1

2

5

Small-scale

0.778

High

124994

IGSF3
Immunoglobulin superfamily member 3

1

0

High-throughput

0.656

High

125005

STOM
Stomatin

2

2

High-throughput

0.606

High

125043

CR3L1
Cyclic AMP-responsive element-binding protein 3-like protein 1

2

1

High-throughput

0.606

High

124989

CDIPT
CDP-diacylglycerol--inositol 3-phosphatidyltransferase

2

0

High-throughput

0.580

High

125029

TM139
Transmembrane protein 139

2

0

High-throughput

0.580

High

125062

ERGI3
Endoplasmic reticulum-Golgi intermediate compartment protein 3

2

0

High-throughput

0.580

High

124992

CREB3
Cyclic AMP-responsive element-binding protein 3

2

1

High-throughput

0.576

High

125016

AQP6
Aquaporin-6

2

1

High-throughput

0.553

High

125057

TM14B
Transmembrane protein 14B

2

1

High-throughput

0.553

High

125015

VPP3
V-type proton ATPase 116 kDa subunit a 3

1

1

High-throughput

0.541

High

124996

PRAF3
PRA1 family protein 3

1

1

High-throughput

0.536

High

125007

HSP13
Heat shock 70 kDa protein 13

1

5

High-throughput

0.536

High

125008

CPT1A
Carnitine O-palmitoyltransferase 1, liver isoform

1

1

High-throughput

0.536

High

125013

AT2C1
Calcium-transporting ATPase type 2C member 1

1

1

High-throughput

0.536

High

125014

TMED1
Transmembrane emp24 domain-containing protein 1

1

1

High-throughput

0.536

High

125018

PTPRN
Receptor-type tyrosine-protein phosphatase-like N

1

1

High-throughput

0.536

High

125025

ERMP1
Endoplasmic reticulum metallopeptidase 1

1

1

High-throughput

0.536

High

125027

GPAT4
Glycerol-3-phosphate acyltransferase 4

1

1

High-throughput

0.536

High

125033

TM87A
Transmembrane protein 87A

1

1

High-throughput

0.536

High

125034

LEMD2
LEM domain-containing protein 2

1

1

High-throughput

0.536

High

125055

RAB18
Ras-related protein Rab-18

1

1

High-throughput

0.536

High

125058

CKLF6
CKLF-like MARVEL transmembrane domain-containing protein 6

1

1

High-throughput

0.536

High

125061

SEC63
Translocation protein SEC63 homolog

1

1

High-throughput

0.536

High

125063

MAN1
Inner nuclear membrane protein Man1

1

1

High-throughput

0.536

High

125028

VSIG1
V-set and immunoglobulin domain-containing protein 1

1

1

High-throughput

0.514

High

124988

EI24
Etoposide-induced protein 2.4 homolog

1

0

High-throughput

0.513

High

124990

SCAM3
Secretory carrier-associated membrane protein 3

1

0

High-throughput

0.513

High

124991

RER1
Protein RER1

1

0

High-throughput

0.513

High

124993

ACSL4
Long-chain-fatty-acid--CoA ligase 4

1

0

High-throughput

0.513

High

124995

MPU1
Mannose-P-dolichol utilization defect 1 protein

1

0

High-throughput

0.513

High

124998

NU1M
NADH-ubiquinone oxidoreductase chain 1

1

0

High-throughput

0.513

High

124999

B3A2
Anion exchange protein 2

1

0

High-throughput

0.513

High

125000

SRPRA
Signal recognition particle receptor subunit alpha

1

0

High-throughput

0.513

High

125002

PPAL
Lysosomal acid phosphatase

1

0

High-throughput

0.513

High

125003

ADT1
ADP/ATP translocase 1

1

0

High-throughput

0.513

High

125017

DHC24
Delta(24)-sterol reductase

1

0

High-throughput

0.513

High

125020

TM63B
Mechanosensitive cation channel TMEM63B

1

0

High-throughput

0.513

High

125021

DRS7B
Dehydrogenase/reductase SDR family member 7B

1

0

High-throughput

0.513

High

125022

MBOA5
Lysophospholipid acyltransferase 5

1

0

High-throughput

0.513

High

125031

K2013
Uncharacterized protein KIAA2013

1

0

High-throughput

0.513

High

125038

PMGT1
Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1

1

0

High-throughput

0.513

High

125039

PIEZ1
Piezo-type mechanosensitive ion channel component 1

1

0

High-throughput

0.513

High

125040

TM9S4
Transmembrane 9 superfamily member 4

1

0

High-throughput

0.513

High

125041

LGAT1
Acyl-CoA:lysophosphatidylglycerol acyltransferase 1

1

0

High-throughput

0.513

High

125042

NCLN
BOS complex subunit NCLN

1

0

High-throughput

0.513

High

125044

COQ8B
Atypical kinase COQ8B, mitochondrial

1

0

High-throughput

0.513

High

125045

YMEL1
ATP-dependent zinc metalloprotease YME1L1

1

0

High-throughput

0.513

High

125047

SGMR1
Sigma non-opioid intracellular receptor 1

1

0

High-throughput

0.513

High

125049

PTSS2
Phosphatidylserine synthase 2

1

0

High-throughput

0.513

High

125051

YIPF3
Protein YIPF3

1

0

High-throughput

0.513

High

125052

DERL2
Derlin-2

1

0

High-throughput

0.513

High

125053

T126A
Transmembrane protein 126A

1

0

High-throughput

0.513

High

49413

TM223
Transmembrane protein 223

1

1

High-throughput

0.489

High

125009

SYJ2B
Synaptojanin-2-binding protein

1

2

High-throughput

0.489

High

125019

GPAT3
Glycerol-3-phosphate acyltransferase 3

1

1

High-throughput

0.489

High

125032

VKORL
Vitamin K epoxide reductase complex subunit 1-like protein 1

1

1

High-throughput

0.489

High

125046

RMD3
Regulator of microtubule dynamics protein 3

1

2

High-throughput

0.489

High

125011

SUMO1
Small ubiquitin-related modifier 1

1

0

Small-scale

0.464

High

125004

CBL
E3 ubiquitin-protein ligase CBL

1

0

High-throughput

0.458

High

125035

CTL5
Choline transporter-like protein 5

1

2

High-throughput

0.445

High

125037

CTL1
Choline transporter-like protein 1

1

2

High-throughput

0.445

High

124997

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

6

High-throughput

0.439

High

125010

KR103
Keratin-associated protein 10-3

1

3

High-throughput

0.439

High

125023

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.437

High

125006

AOFB
Amine oxidase [flavin-containing] B

1

0

High-throughput

0.279

Low

125024

COX15
Heme A synthase COX15

1

0

High-throughput

0.279

Low

125026

TMED4
Transmembrane emp24 domain-containing protein 4

1

0

High-throughput

0.279

Low

125030

GLBL2
Beta-galactosidase-1-like protein 2

1

0

High-throughput

0.279

Low

125036

MCU
Calcium uniporter protein, mitochondrial

1

0

High-throughput

0.279

Low

125048

PGAP4
GPI-N-acetylgalactosamine transferase PGAP4

1

0

High-throughput

0.279

Low

125050

SFXN3
Sideroflexin-3

1

0

High-throughput

0.279

Low

125054

UN93B
Protein unc-93 homolog B1

1

0

High-throughput

0.279

Low

125056

ABCBA
ATP-binding cassette sub-family B member 10, mitochondrial

1

0

High-throughput

0.279

Low

125059

NDUAD
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13

1

0

High-throughput

0.279

Low

125060

EXTL2
Exostosin-like 2

1

0

High-throughput

0.279

Low

125012

UBC9
SUMO-conjugating enzyme UBC9

1

0

Small-scale

0.249

Low

125001

GPHRB
Golgi pH regulator B

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025