HitPredict

Interactor 1: WWP2 (O00308)
NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 2.3.2.26) (Atrophin-1-interacting protein 2) (AIP2) (HECT-type E3 ubiquitin transferase WWP2) (WW domain-containing protein 2)
Gene: WWP2

Interactor 2: RHOQ (P17081)
Rho-related GTP-binding protein RhoQ (Ras-like protein TC10) (Ras-like protein family member 7A)
Gene: RHOQ

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0045944 - positive regulation of transcription by RNA polymerase II GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 870 Hs			1 205
+	Hs
		125711 WWP2_HUMAN (1-870): 0: 982: 100.00		RHOJ_HUMAN (9-204): 1.17e-108: 311: 79.59
+	Hs
		125372 WWP2_HUMAN (1-870): 0: 982: 100.00		RHOG_HUMAN (9-199): 2.46e-81: 241: 54.97
+	Hs
		125349 WWP2_HUMAN (1-870): 0: 982: 100.00		RAC1_HUMAN (10-195): 4.15e-80: 238: 63.98
+	Hs
		125298 WWP2_HUMAN (1-870): 0: 982: 100.00		CDC42_HUMAN (9-193): 1.09e-78: 235: 67.57
+	Hs
		1294861 ITCH_HUMAN (1-870): 0: 902: 54.26		RHOJ_HUMAN (9-204): 1.17e-108: 311: 79.59
+	Hs
		125308 WWP2_HUMAN (1-870): 0: 982: 100.00		RHOA_HUMAN (1-201): 1.3e-76: 230: 49.75
+	Hs
		125135 WWP2_HUMAN (1-870): 0: 982: 100.00		RAC2_HUMAN (10-196): 1.67e-76: 229: 62.03
+	Hs
		125294 WWP2_HUMAN (1-870): 0: 982: 100.00		RAC3_HUMAN (10-183): 9.1e-76: 227: 66.67
+	Hs
		125330 WWP2_HUMAN (1-870): 0: 982: 100.00		RHOB_HUMAN (1-204): 1.77e-75: 227: 49.51
+	Hs
		125100 WWP2_HUMAN (1-870): 0: 982: 100.00		RHOC_HUMAN (1-192): 1.16e-74: 225: 50.52
+	Hs
		564644 ITCH_HUMAN (1-870): 0: 902: 54.26		RHOQ_HUMAN (1-205): 2.78e-83: 247: 100.00
+	Hs
		951237 ITCH_HUMAN (1-870): 0: 902: 54.26		RHOG_HUMAN (9-199): 2.46e-81: 241: 54.97
+	Hs
		925520 ITCH_HUMAN (1-870): 0: 902: 54.26		RAC1_HUMAN (10-195): 4.15e-80: 238: 63.98
+	Hs
		894313 ITCH_HUMAN (1-870): 0: 902: 54.26		CDC42_HUMAN (9-193): 1.09e-78: 235: 67.57
+	Hs
		900802 ITCH_HUMAN (1-870): 0: 902: 54.26		RHOA_HUMAN (1-201): 1.3e-76: 230: 49.75
+	Hs
		545560 ITCH_HUMAN (1-870): 0: 902: 54.26		RAC2_HUMAN (10-196): 1.67e-76: 229: 62.03
+	Hs
		892540 ITCH_HUMAN (1-870): 0: 902: 54.26		RAC3_HUMAN (10-183): 9.1e-76: 227: 66.67
+	Hs
		915895 ITCH_HUMAN (1-870): 0: 902: 54.26		RHOB_HUMAN (1-204): 1.77e-75: 227: 49.51
+	Hs
		436457 ITCH_HUMAN (1-870): 0: 902: 54.26		RHOC_HUMAN (1-192): 1.16e-74: 225: 50.52
+	Hs
		915900 NED4L_HUMAN (5-867): 0: 785: 32.17		RHOB_HUMAN (1-204): 1.77e-75: 227: 49.51