HitPredict

Interactor 1: WWP2 (O00308)
NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 2.3.2.26) (Atrophin-1-interacting protein 2) (AIP2) (HECT-type E3 ubiquitin transferase WWP2) (WW domain-containing protein 2)
Gene: WWP2

Interactor 2: RPB3 (P19387)
DNA-directed RNA polymerase II subunit RPB3 (RNA polymerase II subunit 3) (RNA polymerase II subunit B3) (DNA-directed RNA polymerase II 33 kDa polypeptide) (RPB33) (DNA-directed RNA polymerase II subunit C) (RPB31)
Gene: POLR2C

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.71	0.60	0.656

Property	Details
Experiments	25071155, 31048545, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0006366 - transcription by RNA polymerase II
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 870 Hs			1 275
+	Hs
		583549 ITCH_HUMAN (1-870): 0: 902: 54.26		RPB3_HUMAN (1-275): 6.89e-138: 391: 100.00
+	Hs
		583575 WWP1_HUMAN (1-870): 0: 888: 58.38		RPB3_HUMAN (1-275): 6.89e-138: 391: 100.00
+	Hs
		583423 NEDD4_HUMAN (90-867): 0: 731: 35.94		RPB3_HUMAN (1-275): 6.89e-138: 391: 100.00
+	Hs
		169809 NEDD4_HUMAN (90-867): 0: 731: 35.94		RPAC1_HUMAN (3-269): 1.2e-110: 325: 25.90
+	Sc
		558223 TOM1_YEAST (494-869): 6.11e-158: 514: 40.26		RPB3_YEAST (4-271): 9.52e-107: 313: 45.06
+	Sc
		429760 TOM1_YEAST (494-869): 6.11e-158: 514: 40.26		RPAC1_YEAST (3-261): 1.36e-96: 288: 25.42
+	Hs
		583590 SMUF1_HUMAN (1-385): 1.35e-45: 177: 17.77		RPB3_HUMAN (1-275): 6.89e-138: 391: 100.00
+	Sc
		558068 RSP5_YEAST (16-376): 1.4e-39: 159: 18.39		RPB3_YEAST (4-271): 9.52e-107: 313: 45.06