Protein: VATB2
V-type proton ATPase subunit B, brain isoform (V-ATPase subunit B 2) (Endomembrane proton pump 58 kDa subunit) (HO57) (Vacuolar proton pump subunit B 2)

Gene: VATB2, ATP6V1B2
Organism: Homo sapiens
Interactions: 138
UniProt ID: P21281

Gene Ontology (top 5):
GO:0000221 - vacuolar proton-transporting V-type ATPase, V1 domain
GO:0001726 - ruffle
GO:0005524 - ATP binding
GO:0005765 - lysosomal membrane
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

636998

VATA
V-type proton ATPase catalytic subunit A

10

18

Small-scale

0.967

High

636997

VATE1
V-type proton ATPase subunit E 1

7

7

High-throughput

0.954

High

583054

VATB1
V-type proton ATPase subunit B, kidney isoform

6

11

High-throughput

0.935

High

637082

VATD
V-type proton ATPase subunit D

4

4

High-throughput

0.881

High

637022

VATF
V-type proton ATPase subunit F

3

4

High-throughput

0.839

High

637055

VATE2
V-type proton ATPase subunit E 2

3

7

High-throughput

0.817

High

637046

VATC2
V-type proton ATPase subunit C 2

5

7

High-throughput

0.712

High

637073

VATH
V-type proton ATPase subunit H

5

4

High-throughput

0.706

High

49504

TLDC2
TLD domain-containing protein 2

2

8

High-throughput

0.705

High

637080

VPP2
V-type proton ATPase 116 kDa subunit a 2

4

9

High-throughput

0.691

High

637054

VPP1
V-type proton ATPase 116 kDa subunit a 1

4

9

Small-scale

0.683

High

292552

RENR
Renin receptor

3

1

High-throughput

0.662

High

276816

VATG1
V-type proton ATPase subunit G 1

3

8

High-throughput

0.650

High

636990

VATC1
V-type proton ATPase subunit C 1

3

7

High-throughput

0.650

High

637049

DMXL2
DmX-like protein 2

3

8

High-throughput

0.650

High

637079

DMXL1
DmX-like protein 1

3

8

High-throughput

0.650

High

637028

LTOR1
Ragulator complex protein LAMTOR1

3

2

Small-scale

0.633

High

637005

RAB7A
Ras-related protein Rab-7a

2

5

High-throughput

0.628

High

341195

VATG2
V-type proton ATPase subunit G 2

3

8

High-throughput

0.624

High

637030

MEAK7
MTOR-associated protein MEAK7

1

9

High-throughput

0.618

High

637075

TBC24
TBC1 domain family member 24

1

7

High-throughput

0.618

High

637010

VA0D1
V-type proton ATPase subunit d 1

2

5

Small-scale

0.611

High

637081

WDR7
WD repeat-containing protein 7

3

12

High-throughput

0.593

High

105323

APRIO
Alternative prion protein

3

1

Small-scale

0.586

High

240739

PRKN
E3 ubiquitin-protein ligase parkin

2

8

High-throughput

0.584

High

529069

TAU
Microtubule-associated protein tau

2

5

High-throughput

0.584

High

637006

RAB9A
Ras-related protein Rab-9A

2

4

High-throughput

0.584

High

395487

ESR1
Estrogen receptor

2

4

High-throughput

0.571

High

637018

VPP3
V-type proton ATPase 116 kDa subunit a 3

2

9

High-throughput

0.571

High

637068

VPP4
V-type proton ATPase 116 kDa subunit a 4

2

9

High-throughput

0.571

High

637048

NCOA7
Nuclear receptor coactivator 7

1

8

High-throughput

0.553

High

542743

G6PD
Glucose-6-phosphate 1-dehydrogenase

2

0

High-throughput

0.547

High

64934

ARRD5
Arrestin domain-containing protein 5

1

1

High-throughput

0.536

High

389023

FINC
Fibronectin

1

5

High-throughput

0.536

High

636993

VATL
V-type proton ATPase 16 kDa proteolipid subunit c

1

3

High-throughput

0.536

High

636996

STIP1
Stress-induced-phosphoprotein 1

1

8

High-throughput

0.536

High

637004

RAB5C
Ras-related protein Rab-5C

1

4

High-throughput

0.536

High

637008

RAB2A
Ras-related protein Rab-2A

1

3

High-throughput

0.536

High

637009

RAB14
Ras-related protein Rab-14

1

3

High-throughput

0.536

High

637015

CLH1
Clathrin heavy chain 1

1

2

High-throughput

0.536

High

637019

VAMP3
Vesicle-associated membrane protein 3

1

3

High-throughput

0.536

High

637025

TM63B
Mechanosensitive cation channel TMEM63B

1

1

High-throughput

0.536

High

637029

IFIX
Pyrin and HIN domain-containing protein 1

1

1

High-throughput

0.536

High

637035

RRAGA
Ras-related GTP-binding protein A

1

3

High-throughput

0.536

High

637051

TFG
Protein TFG

1

2

High-throughput

0.536

High

637057

SYGP1
Ras/Rap GTPase-activating protein SynGAP

1

1

High-throughput

0.536

High

637065

CHM4B
Charged multivesicular body protein 4b

1

3

High-throughput

0.536

High

637071

VAPA
Vesicle-associated membrane protein-associated protein A

1

1

High-throughput

0.536

High

637078

GOT1B
Vesicle transport protein GOT1B

1

1

High-throughput

0.536

High

451122

NFL
Neurofilament light polypeptide

1

2

High-throughput

0.515

High

570356

GFAP
Glial fibrillary acidic protein

1

2

High-throughput

0.515

High

636999

HD
Huntingtin

1

2

High-throughput

0.515

High

637077

RNF11
RING finger protein 11

1

4

High-throughput

0.515

High

610984

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

0

High-throughput

0.513

High

637020

VAS1
V-type proton ATPase subunit S1

1

0

High-throughput

0.513

High

637043

S38A9
Neutral amino acid transporter 9

1

0

Small-scale

0.513

High

637076

LTOR2
Ragulator complex protein LAMTOR2

1

0

Small-scale

0.513

High

637050

JPH3
Junctophilin-3

1

0

High-throughput

0.493

High

249092

DSCAM
Cell adhesion molecule DSCAM

1

3

High-throughput

0.481

High

125226

LEG9
Galectin-9

1

4

High-throughput

0.479

High

178182

NPC1
NPC intracellular cholesterol transporter 1

1

2

High-throughput

0.479

High

189420

STX7
Syntaxin-7

1

2

High-throughput

0.479

High

208461

PJA2
E3 ubiquitin-protein ligase Praja-2

1

2

Small-scale

0.479

High

217824

TGON2
Trans-Golgi network integral membrane protein 2

1

3

High-throughput

0.479

High

225935

STX6
Syntaxin-6

1

1

High-throughput

0.479

High

400273

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

2

High-throughput

0.479

High

411343

NTRK1
High affinity nerve growth factor receptor

1

5

High-throughput

0.479

High

420357

AT1A1
Sodium/potassium-transporting ATPase subunit alpha-1

1

2

High-throughput

0.479

High

461142

HS90A
Heat shock protein HSP 90-alpha

1

8

High-throughput

0.479

High

468063

HS90B
Heat shock protein HSP 90-beta

1

8

High-throughput

0.479

High

507521

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

7

High-throughput

0.479

High

541335

FGFR1
Fibroblast growth factor receptor 1

1

5

High-throughput

0.479

High

560305

IFM1
Interferon-induced transmembrane protein 1

1

3

High-throughput

0.479

High

630455

RAB3B
Ras-related protein Rab-3B

1

2

High-throughput

0.479

High

630688

RAB4A
Ras-related protein Rab-4A

1

3

High-throughput

0.479

High

631057

RAB5A
Ras-related protein Rab-5A

1

4

High-throughput

0.479

High

635489

NEBU
Nebulin

1

1

High-throughput

0.479

High

636991

CBL
E3 ubiquitin-protein ligase CBL

1

1

High-throughput

0.479

High

636992

SYTC
Threonine--tRNA ligase 1, cytoplasmic

1

1

High-throughput

0.479

High

636995

EPHB2
Ephrin type-B receptor 2

1

3

High-throughput

0.479

High

637000

ATRX
Transcriptional regulator ATRX

1

8

High-throughput

0.479

High

637001

SOX2
Transcription factor SOX-2

1

2

High-throughput

0.479

High

637003

DNLI3
DNA ligase 3

1

2

High-throughput

0.479

High

637007

HDAC4
Histone deacetylase 4

1

3

High-throughput

0.479

High

637011

RS7
Small ribosomal subunit protein eS7

1

1

High-throughput

0.479

High

637012

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

3

High-throughput

0.479

High

637014

SKP1
S-phase kinase-associated protein 1

1

2

Small-scale

0.479

High

637016

IFM3
Interferon-induced transmembrane protein 3

1

3

High-throughput

0.479

High

637017

TP4A2
Protein tyrosine phosphatase type IVA 2

1

1

Small-scale

0.479

High

637023

PAN2
PAN2-PAN3 deadenylation complex catalytic subunit PAN2

1

1

High-throughput

0.479

High

637027

VIR
Protein virilizer homolog

1

1

High-throughput

0.479

High

637033

LMTK1
Serine/threonine-protein kinase LMTK1

1

5

High-throughput

0.479

High

637036

RBBP6
E3 ubiquitin-protein ligase RBBP6

1

5

High-throughput

0.479

High

637038

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

5

Small-scale

0.479

High

637039

TM192
Transmembrane protein 192

1

1

High-throughput

0.479

High

637041

VA0D2
V-type proton ATPase subunit d 2

1

5

High-throughput

0.479

High

637042

LRC57
Leucine-rich repeat-containing protein 57

1

1

High-throughput

0.479

High

637044

SERB1
SERPINE1 mRNA-binding protein 1

1

2

High-throughput

0.479

High

637047

TNIP2
TNFAIP3-interacting protein 2

1

1

High-throughput

0.479

High

637052

GOGA1
Golgin subfamily A member 1

1

3

High-throughput

0.479

High

637053

RIT1
GTP-binding protein Rit1

1

6

High-throughput

0.479

High

637060

ACE2
Angiotensin-converting enzyme 2

1

1

High-throughput

0.479

High

637063

CCDC8
Coiled-coil domain-containing protein 8

1

2

High-throughput

0.479

High

637064

DNJC5
DnaJ homolog subfamily C member 5

1

2

High-throughput

0.479

High

637066

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.479

High

637072

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

301337

WFS1
Wolframin

1

1

High-throughput

0.470

High

637013

RB11A
Ras-related protein Rab-11A

1

0

High-throughput

0.458

High

637032

RICTR
Rapamycin-insensitive companion of mTOR

1

0

High-throughput

0.458

High

637040

MALD2
MARVEL domain-containing protein 2

1

0

High-throughput

0.458

High

637070

DISC1
Disrupted in schizophrenia 1 protein

1

1

High-throughput

0.457

High

609573

LEG3
Galectin-3

1

4

High-throughput

0.445

High

637024

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

1

High-throughput

0.445

High

637026

A16L1
Autophagy-related protein 16-1

1

5

High-throughput

0.445

High

637067

RRAGC
Ras-related GTP-binding protein C

1

3

High-throughput

0.445

High

637056

LCOR
Ligand-dependent corepressor

1

1

High-throughput

0.439

High

636994

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

2

High-throughput

0.437

High

637002

PRI2
DNA primase large subunit

1

1

High-throughput

0.437

High

637021

EZH2
Histone-lysine N-methyltransferase EZH2

1

4

High-throughput

0.437

High

637034

TRI67
Tripartite motif-containing protein 67

1

5

High-throughput

0.437

High

637045

PNMA1
Paraneoplastic antigen Ma1

1

2

High-throughput

0.437

High

637074

XPO7
Exportin-7

1

2

High-throughput

0.437

High

404664

PRIO
Major prion protein

1

0

High-throughput

0.426

High

637061

ZDHC5
Palmitoyltransferase ZDHHC5

1

0

High-throughput

0.426

High

429296

JUN
Transcription factor Jun

1

4

High-throughput

0.407

High

637031

CSAG1
Chondrosarcoma-associated gene 1 protein

1

2

High-throughput

0.407

High

637083

CSAG2
Chondrosarcoma-associated gene 2/3 protein

1

2

High-throughput

0.407

High

637062

ROGDI
Protein rogdi homolog

2

0

High-throughput

0.313

High

586999

ITF2
Transcription factor 4

1

0

High-throughput

0.299

High

338052

NSA2
Ribosome biogenesis protein NSA2 homolog

1

0

High-throughput

0.279

Low

637058

EYA1
Protein phosphatase EYA1

1

0

High-throughput

0.279

Low

637069

MED4
Mediator of RNA polymerase II transcription subunit 4

1

0

High-throughput

0.279

Low

63794

RGSL
Regulator of G-protein signaling protein-like

1

0

High-throughput

0.249

Low

139812

RCAS1
Receptor-binding cancer antigen expressed on SiSo cells

1

0

High-throughput

0.249

Low

247672

NUPR1
Nuclear protein 1

1

0

High-throughput

0.249

Low

567163

ZNF35
Zinc finger protein 35

1

0

High-throughput

0.249

Low

637037

GALT5
Polypeptide N-acetylgalactosaminyltransferase 5

1

0

High-throughput

0.249

Low

637059

GORS1
Golgi reassembly-stacking protein 1

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025