HitPredict

Interactor 1: DPTOR (Q8TB45)
DEP domain-containing mTOR-interacting protein (hDEPTOR) (DEP domain-containing protein 6)
Gene: DEPTOR

Interactor 2: FBW1A (Q9Y297)
F-box/WD repeat-containing protein 1A (E3RSIkappaB) (Epididymis tissue protein Li 2a) (F-box and WD repeats protein beta-TrCP) (pIkappaBalpha-E3 receptor subunit)
Gene: BTRC

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.92	0.80	0.858

Property	Details
Experiments	21516116, 22017876, 33995662, 22017877, 22017875, 26091241
Identification Methods	two hybrid, affinity chromatography technology, pull down, enzymatic study
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	DEP~WD40
Common GO terms	-
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 409 Hs			1 605
+	Hs
		1252047 DPTOR_HUMAN (1-409): 0: 519: 100.00		FBW1B_HUMAN (96-605): 1.89e-143: 428: 85.69
+	Hs
		1252036 DPTOR_HUMAN (1-409): 0: 519: 100.00		FBXW7_HUMAN (76-527): 7.38e-83: 276: 23.71
+	Mm
		1123033 DPTOR_MOUSE (1-409): 2.35e-180: 509: 96.09		FBXW7_MOUSE (76-527): 2.98e-83: 277: 23.71
+	Hs
		1254029 PREX1_HUMAN (23-382): 2.96e-138: 434: 29.29		NLE1_HUMAN (33-408): 1.35e-41: 159: 13.21