HitPredict

Interactor 1: LNX1 (Q8TBB1)
E3 ubiquitin-protein ligase LNX (EC 2.3.2.27) (Ligand of Numb-protein X 1) (Numb-binding protein 1) (PDZ domain-containing RING finger protein 2) (RING-type E3 ubiquitin transferase LNX)
Gene: LNX1

Interactor 2: TRIM1 (Q9UJV3)
Probable E3 ubiquitin-protein ligase MID2 (EC 2.3.2.27) (Midin-2) (Midline defect 2) (Midline-2) (RING finger protein 60) (RING-type E3 ubiquitin transferase MID2) (Tripartite motif-containing protein 1)
Gene: MID2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.77	1.00	0.881

Property	Details
Experiments	29121065, 32296183, unassigned1654, unassigned1304
Identification Methods	affinity chromatography technology, two hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	zf-B_box~zf-C3HC4
Common GO terms	GO:0005737 - cytoplasm GO:0016567 - protein ubiquitination
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 728 Hs			1 735
+	Hs
		175698 LNX1_HUMAN (1-728): 1.08e-139: 429: 100.00		TRI18_HUMAN (21-717): 8.76e-175: 518: 72.60
+	Mm
		250640 LNX1_MOUSE (1-728): 8.14e-134: 414: 87.98		TRIM9_MOUSE (21-714): 9.41e-100: 327: 19.86
+	Hs
		50950 LNX1_HUMAN (1-728): 1.08e-139: 429: 100.00		FSD2_HUMAN (206-712): 2.04e-81: 276: 22.86
+	Hs
		1219888 LNX1_HUMAN (1-728): 1.08e-139: 429: 100.00		TRI42_HUMAN (24-422): 6.87e-73: 252: 22.87
+	Hs
		1252462 LNX1_HUMAN (1-728): 1.08e-139: 429: 100.00		TRIM8_HUMAN (16-417): 5.14e-61: 216: 20.34
+	Hs
		1252460 LNX1_HUMAN (1-728): 1.08e-139: 429: 100.00		TRI54_HUMAN (184-400): 2.63e-53: 190: 23.96
+	Hs
		1115440 LNX1_HUMAN (1-728): 1.08e-139: 429: 100.00		TRI60_HUMAN (19-301): 3.27e-29: 123: 15.55
+	Hs
		1252493 LNX1_HUMAN (1-728): 1.08e-139: 429: 100.00		TRI39_HUMAN (21-389): 6.9e-27: 117: 12.81
+	Hs
		585019 LNX1_HUMAN (1-728): 1.08e-139: 429: 100.00		RO52_HUMAN (16-316): 3.12e-24: 108: 13.86
+	Hs
		536942 LNX1_HUMAN (1-728): 1.08e-139: 429: 100.00		TRI27_HUMAN (16-340): 1.18e-23: 107: 14.15
+	Hs
		1149890 LNX1_HUMAN (1-728): 1.08e-139: 429: 100.00		TRI68_HUMAN (126-458): 2.92e-19: 93.6: 14.36
+	Hs
		734704 LNX1_HUMAN (1-728): 1.08e-139: 429: 100.00		TRI23_HUMAN (28-272): 6.41e-17: 86.7: 24.71
+	Hs
		1049092 LNX1_HUMAN (1-728): 1.08e-139: 429: 100.00		TRI14_HUMAN (192-413): 5.06e-11: 67.6: 19.30
+	Hs
		1170960 PARD3_HUMAN (247-554): 1.39e-32: 137: 20.96		TRI67_HUMAN (74-718): 5.93e-89: 297: 22.96
+	Hs
		1021518 DLG1_HUMAN (354-728): 3.16e-29: 126: 16.15		TRI67_HUMAN (74-718): 5.93e-89: 297: 22.96
+	Hs
		280047 MPDZ_HUMAN (513-728): 2.84e-20: 98.6: 18.43		TRI67_HUMAN (74-718): 5.93e-89: 297: 22.96
+	Hs
		1049988 SCRIB_HUMAN (265-624): 2.64e-15: 82.4: 13.52		TRI67_HUMAN (74-718): 5.93e-89: 297: 22.96