Protein: SYDC
Aspartate--tRNA ligase, cytoplasmic (EC 6.1.1.12) (Aspartyl-tRNA synthetase) (AspRS) (Cell proliferation-inducing gene 40 protein)

Gene: SYDC, DARS1
Organism: Homo sapiens
Interactions: 186
UniProt ID: P14868

Gene Ontology (top 5):
GO:0003723 - RNA binding
GO:0004046 - aminoacylase activity
GO:0004815 - aspartate-tRNA ligase activity
GO:0005524 - ATP binding
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

541354

AIMP2
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

7

3

Small-scale

0.968

High

541365

SYK
Lysine--tRNA ligase

2

12

High-throughput

0.811

High

132734

SDCB1
Syntenin-1

3

1

High-throughput

0.667

High

541333

SYRC
Arginine--tRNA ligase, cytoplasmic

3

2

High-throughput

0.667

High

541427

SYLC
Leucine--tRNA ligase, cytoplasmic

3

12

High-throughput

0.667

High

528473

CFTR
Cystic fibrosis transmembrane conductance regulator

3

3

High-throughput

0.650

High

226423

PRKN
E3 ubiquitin-protein ligase parkin

3

9

High-throughput

0.640

High

322137

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

3

2

High-throughput

0.640

High

503365

HSP7C
Heat shock cognate 71 kDa protein

3

1

High-throughput

0.633

High

541328

SYQ
Glutamine--tRNA ligase

2

11

High-throughput

0.628

High

541352

AIMP1
Aminoacyl tRNA synthase complex-interacting multifunctional protein 1

2

6

High-throughput

0.628

High

541324

SYIC
Isoleucine--tRNA ligase, cytoplasmic

2

9

Small-scale

0.611

High

541344

GRB2
Growth factor receptor-bound protein 2

2

1

High-throughput

0.611

High

541358

CUL3
Cullin-3

2

6

High-throughput

0.611

High

541389

CMTD1
Catechol O-methyltransferase domain-containing protein 1

2

1

High-throughput

0.611

High

368920

ESR1
Estrogen receptor

2

5

Small-scale

0.585

High

373631

RAF1
RAF proto-oncogene serine/threonine-protein kinase

2

3

High-throughput

0.584

High

541423

ANLN
Anillin

2

2

High-throughput

0.584

High

401350

JUN
Transcription factor Jun

1

4

High-throughput

0.554

High

541309

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

3

High-throughput

0.553

High

541317

RFA3
Replication protein A 14 kDa subunit

1

3

High-throughput

0.553

High

541306

VCAM1
Vascular cell adhesion protein 1

2

0

High-throughput

0.547

High

541321

SYUA
Alpha-synuclein

2

0

High-throughput

0.547

High

202821

EMC8
ER membrane protein complex subunit 8

1

3

High-throughput

0.536

High

336347

SODC
Superoxide dismutase [Cu-Zn]

1

1

High-throughput

0.536

High

541319

RL4
Large ribosomal subunit protein uL4

1

1

High-throughput

0.536

High

541327

CAPZB
F-actin-capping protein subunit beta

1

2

High-throughput

0.536

High

541341

RS16
Small ribosomal subunit protein uS9

1

1

High-throughput

0.536

High

541345

RACK1
Small ribosomal subunit protein RACK1

1

7

High-throughput

0.536

High

541357

CUL1
Cullin-1

1

6

High-throughput

0.536

High

541360

CAPR1
Caprin-1

1

3

High-throughput

0.536

High

541362

CND2
Condensin complex subunit 2

1

1

High-throughput

0.536

High

541369

PKN2
Serine/threonine-protein kinase N2

1

2

High-throughput

0.536

High

541401

CUL5
Cullin-5

1

6

High-throughput

0.536

High

541410

HCD2
3-hydroxyacyl-CoA dehydrogenase type-2

1

3

High-throughput

0.536

High

541437

DRG1
Developmentally-regulated GTP-binding protein 1

1

1

High-throughput

0.536

High

541439

EMC9
ER membrane protein complex subunit 9

1

3

High-throughput

0.536

High

331201

CHK2
Serine/threonine-protein kinase Chk2

1

1

High-throughput

0.515

High

429818

CATL1
Procathepsin L

1

2

High-throughput

0.515

High

541323

CCNF
Cyclin-F

1

2

High-throughput

0.515

High

128425

DNM1L
Dynamin-1-like protein

1

0

High-throughput

0.513

High

283376

SRP72
Signal recognition particle subunit SRP72

1

0

High-throughput

0.513

High

541307

VDAC1
Voltage-dependent anion-selective channel protein 1

1

0

High-throughput

0.513

High

541320

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

0

High-throughput

0.513

High

541348

RL19
Large ribosomal subunit protein eL19

1

0

High-throughput

0.513

High

541430

SRP68
Signal recognition particle subunit SRP68

1

0

High-throughput

0.513

High

541397

P55G
Phosphatidylinositol 3-kinase regulatory subunit gamma

1

3

High-throughput

0.508

High

541351

FOXM1
Forkhead box protein M1

1

2

High-throughput

0.506

High

541338

SUMO2
Small ubiquitin-related modifier 2

1

4

High-throughput

0.501

High

541347

EF1A1
Elongation factor 1-alpha 1

1

3

Small-scale

0.501

High

541398

NDRG1
Protein NDRG1

1

0

Small-scale

0.493

High

541378

FOXI2
Forkhead box protein I2

1

1

High-throughput

0.489

High

541406

RMC1
Regulator of MON1-CCZ1 complex

1

1

High-throughput

0.489

High

541412

FOXB1
Forkhead box protein B1

1

2

High-throughput

0.489

High

541349

ERCC6
DNA excision repair protein ERCC-6

1

0

High-throughput

0.480

High

125133

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

5

High-throughput

0.479

High

130722

PSDE
26S proteasome non-ATPase regulatory subunit 14

1

4

High-throughput

0.479

High

148353

CTRO
Citron Rho-interacting kinase

1

3

High-throughput

0.479

High

169376

BET1
BET1 homolog

1

1

High-throughput

0.479

High

201199

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

1

High-throughput

0.479

High

214068

SPOP
Speckle-type POZ protein

1

1

High-throughput

0.479

High

294331

RECQ4
ATP-dependent DNA helicase Q4

1

1

High-throughput

0.479

High

298119

UFL1
E3 UFM1-protein ligase 1

1

1

High-throughput

0.479

High

301593

TRI37
E3 ubiquitin-protein ligase TRIM37

1

5

High-throughput

0.479

High

302868

HEXI1
Protein HEXIM1

1

1

High-throughput

0.479

High

328724

TOP3B
DNA topoisomerase 3-beta-1

1

1

High-throughput

0.479

High

345831

MYC
Myc proto-oncogene protein

1

2

High-throughput

0.479

High

349845

RASK
GTPase KRas

1

1

High-throughput

0.479

High

362775

FINC
Fibronectin

1

2

High-throughput

0.479

High

384203

NTRK1
High affinity nerve growth factor receptor

1

5

High-throughput

0.479

High

397758

ISG15
Ubiquitin-like protein ISG15

1

7

High-throughput

0.479

High

422340

NFM
Neurofilament medium polypeptide

1

1

High-throughput

0.479

High

475301

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

7

High-throughput

0.479

High

530399

ITA4
Integrin alpha-4

1

4

High-throughput

0.479

High

541302

UCHL3
Ubiquitin carboxyl-terminal hydrolase isozyme L3

1

3

Small-scale

0.479

High

541305

CEBPB
CCAAT/enhancer-binding protein beta

1

4

High-throughput

0.479

High

541308

U2AF2
Splicing factor U2AF 65 kDa subunit

1

1

High-throughput

0.479

High

541310

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

4

High-throughput

0.479

High

541311

UFO
Tyrosine-protein kinase receptor UFO

1

6

High-throughput

0.479

High

541313

STIP1
Stress-induced-phosphoprotein 1

1

5

High-throughput

0.479

High

541314

CTNB1
Catenin beta-1

1

2

High-throughput

0.479

High

541315

PHB1
Prohibitin 1

1

1

High-throughput

0.479

High

541316

MERL
Merlin

1

1

High-throughput

0.479

High

541318

VGFR3
Vascular endothelial growth factor receptor 3

1

5

High-throughput

0.479

High

541322

BRCA1
Breast cancer type 1 susceptibility protein

1

2

High-throughput

0.479

High

541326

MAP1B
Microtubule-associated protein 1B

1

1

High-throughput

0.479

High

541329

SOX2
Transcription factor SOX-2

1

1

High-throughput

0.479

High

541332

MCM2
DNA replication licensing factor MCM2

1

2

High-throughput

0.479

High

541334

ATX3
Ataxin-3

1

1

High-throughput

0.479

High

541335

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

1

3

High-throughput

0.479

High

541342

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

2

High-throughput

0.479

High

541343

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

4

High-throughput

0.479

High

541353

NFX1
Transcriptional repressor NF-X1

1

2

High-throughput

0.479

High

541355

TIF1B
Transcription intermediary factor 1-beta

1

3

High-throughput

0.479

High

541356

BIRC3
Baculoviral IAP repeat-containing protein 3

1

1

High-throughput

0.479

High

541359

CUL4A
Cullin-4A

1

6

High-throughput

0.479

High

541363

TNIP1
TNFAIP3-interacting protein 1

1

3

High-throughput

0.479

High

541364

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

4

High-throughput

0.479

High

541366

KIF14
Kinesin-like protein KIF14

1

1

High-throughput

0.479

High

541368

EZH2
Histone-lysine N-methyltransferase EZH2

1

3

High-throughput

0.479

High

541370

CRY1
Cryptochrome-1

1

1

High-throughput

0.479

High

541371

CRY2
Cryptochrome-2

1

1

High-throughput

0.479

High

541374

A16L1
Autophagy-related protein 16-1

1

7

High-throughput

0.479

High

541375

VIR
Protein virilizer homolog

1

2

High-throughput

0.479

High

541376

PRP8
Pre-mRNA-processing-splicing factor 8

1

1

High-throughput

0.479

High

541377

FGD5
FYVE, RhoGEF and PH domain-containing protein 5

1

1

High-throughput

0.479

High

541379

TRI67
Tripartite motif-containing protein 67

1

3

High-throughput

0.479

High

541380

MOB3C
MOB kinase activator 3C

1

1

High-throughput

0.479

High

541384

TM11B
Transmembrane protease serine 11B

1

2

High-throughput

0.479

High

541385

ZN598
E3 ubiquitin-protein ligase ZNF598

1

4

High-throughput

0.479

High

541386

NAA40
N-alpha-acetyltransferase 40

1

1

High-throughput

0.479

High

541388

ZCH18
Zinc finger CCCH domain-containing protein 18

1

1

High-throughput

0.479

High

541391

COP1
E3 ubiquitin-protein ligase COP1

1

7

High-throughput

0.479

High

541392

TIP
T-cell immunomodulatory protein

1

1

High-throughput

0.479

High

541393

FBX25
F-box only protein 25

1

1

High-throughput

0.479

High

541396

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

3

High-throughput

0.479

High

541400

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

4

Small-scale

0.479

High

541402

FBXW7
F-box/WD repeat-containing protein 7

1

5

High-throughput

0.479

High

541404

ARMC5
Armadillo repeat-containing protein 5

1

4

High-throughput

0.479

High

541405

CHM4C
Charged multivesicular body protein 4c

1

1

High-throughput

0.479

High

541408

DDRGK
DDRGK domain-containing protein 1

1

1

High-throughput

0.479

High

541409

NECD
Necdin

1

1

High-throughput

0.479

High

541413

ANM1
Protein arginine N-methyltransferase 1

1

4

High-throughput

0.479

High

541421

PKHA4
Pleckstrin homology domain-containing family A member 4

1

4

High-throughput

0.479

High

541422

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

1

High-throughput

0.479

High

541424

FBX6
F-box only protein 6

1

1

High-throughput

0.479

High

541425

RAD18
E3 ubiquitin-protein ligase RAD18

1

1

High-throughput

0.479

High

541426

UBP36
Ubiquitin carboxyl-terminal hydrolase 36

1

2

High-throughput

0.479

High

541429

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.479

High

541431

MKRN1
E3 ubiquitin-protein ligase makorin-1

1

1

High-throughput

0.479

High

541434

FZR1
Fizzy-related protein homolog

1

6

High-throughput

0.479

High

541435

HDAC5
Histone deacetylase 5

1

4

High-throughput

0.479

High

541440

RBM8A
RNA-binding protein 8A

1

1

High-throughput

0.479

High

119136

LEG9
Galectin-9

1

0

High-throughput

0.458

High

122473

MEN1
Menin

1

0

High-throughput

0.458

High

326417

SNAI1
Zinc finger protein SNAI1

1

0

High-throughput

0.458

High

337865

EGFR
Epidermal growth factor receptor

1

0

High-throughput

0.458

High

436670

GLI1
Zinc finger protein GLI1

1

0

Small-scale

0.458

High

541325

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

0

High-throughput

0.458

High

541337

UBC12
NEDD8-conjugating enzyme Ubc12

1

0

High-throughput

0.458

High

541346

ACTC
Actin, alpha cardiac muscle 1

1

0

High-throughput

0.458

High

541361

CUL7
Cullin-7

1

0

High-throughput

0.458

High

541367

PCBP1
Poly(rC)-binding protein 1

1

0

Small-scale

0.458

High

541372

LARP7
La-related protein 7

1

0

High-throughput

0.458

High

541394

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.458

High

541399

FGF11
Fibroblast growth factor 11

1

0

High-throughput

0.458

High

541411

ACON
Aconitate hydratase, mitochondrial

1

0

High-throughput

0.458

High

541414

RIOK1
Serine/threonine-protein kinase RIO1

1

0

High-throughput

0.458

High

541415

TRI31
E3 ubiquitin-protein ligase TRIM31

1

0

High-throughput

0.458

High

541419

CCDC8
Coiled-coil domain-containing protein 8

1

0

High-throughput

0.458

High

541432

BAG5
BAG family molecular chaperone regulator 5

1

0

High-throughput

0.458

High

431494

HS90A
Heat shock protein HSP 90-alpha

1

6

Small-scale

0.457

High

541383

SDCG8
Serologically defined colon cancer antigen 8

1

4

Small-scale

0.445

High

541420

MLP3A
Microtubule-associated proteins 1A/1B light chain 3A

1

2

High-throughput

0.445

High

541436

ITM2B
Integral membrane protein 2B

1

1

High-throughput

0.445

High

500707

CLUS
Clusterin

1

0

High-throughput

0.438

High

182532

R113A
E3 ubiquitin-protein ligase RNF113A

1

1

High-throughput

0.437

High

541303

RFA2
Replication protein A 32 kDa subunit

1

3

High-throughput

0.437

High

541330

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

2

High-throughput

0.437

High

541339

WDR5
WD repeat-containing protein 5

1

5

High-throughput

0.437

High

541350

TLE2
Transducin-like enhancer protein 2

1

6

High-throughput

0.437

High

541381

ASXL2
Putative Polycomb group protein ASXL2

1

2

High-throughput

0.437

High

541395

CLC4D
C-type lectin domain family 4 member D

1

2

High-throughput

0.437

High

541417

ASXL3
Putative Polycomb group protein ASXL3

1

3

High-throughput

0.437

High

541428

TR10D
Tumor necrosis factor receptor superfamily member 10D

1

1

High-throughput

0.437

High

541433

HECD1
E3 ubiquitin-protein ligase HECTD1

1

5

High-throughput

0.437

High

323571

BAG2
BAG family molecular chaperone regulator 2

1

0

Small-scale

0.426

High

541340

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

0

High-throughput

0.426

High

541390

RYBP
RING1 and YY1-binding protein

1

0

High-throughput

0.426

High

541416

ZDHC5
Palmitoyltransferase ZDHHC5

1

0

High-throughput

0.426

High

541336

DSCR9
Down syndrome critical region protein 9

1

1

High-throughput

0.417

High

239754

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

1

High-throughput

0.407

High

541331

CEBPA
CCAAT/enhancer-binding protein alpha

1

4

High-throughput

0.373

High

541418

SPRTN
DNA-dependent metalloprotease SPRTN

2

0

Small-scale

0.305

High

452608

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

0

High-throughput

0.279

Low

541312

SDHA
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

1

0

High-throughput

0.279

Low

541407

COQ2
4-hydroxybenzoate polyprenyltransferase, mitochondrial

1

0

High-throughput

0.279

Low

541304

TAL1
T-cell acute lymphocytic leukemia protein 1

1

0

High-throughput

0.261

Low

225506

PCDH7
Protocadherin-7

1

0

High-throughput

0.249

Low

329314

AGR2
Anterior gradient protein 2 homolog

1

0

High-throughput

0.249

Low

541382

KCTD9
BTB/POZ domain-containing protein KCTD9

1

0

High-throughput

0.249

Low

541387

PAQR2
Adiponectin receptor protein 2

1

0

Small-scale

0.249

Low

541403

LENG1
Leukocyte receptor cluster member 1

1

0

High-throughput

0.249

Low

541438

AAR2
Protein AAR2 homolog

1

0

High-throughput

0.249

Low

916

SIM26
Small integral membrane protein 26

1

0

High-throughput

0.232

Low

541373

LITD1
LINE-1 type transposase domain-containing protein 1

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024