Interactor 1: WWP2 (O00308)
NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 2.3.2.26) (Atrophin-1-interacting protein 2) (AIP2) (HECT-type E3 ubiquitin transferase WWP2) (WW domain-containing protein 2)
Gene: WWP2

Interactor 2: UB2D3 (P61077)
Ubiquitin-conjugating enzyme E2 D3 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme D3) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme D3) (Ubiquitin carrier protein D3) (Ubiquitin-conjugating enzyme E2(17)KB 3) (Ubiquitin-conjugating enzyme E2-17 kDa 3) (Ubiquitin-protein ligase D3)
Gene: UBE2D3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.92 1.00 0.960

The method score is based on:

Property Details
Experiments 25266661, 25723849, 33107021, 33484499, 34732716, 35331737, 23644597
Identification Methods pull down, enzymatic study
Interaction Type direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains HECT~UQ_con
Common GO terms GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000151 - ubiquitin ligase complex
GO:0004842 - ubiquitin-protein transferase activity
GO:0005634 - nucleus
GO:0005829 - cytosol
and 6 others

more...

Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 870
Hs

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Last updated: 15 Jul 2024