Protein: LEG8
Galectin-8 (Gal-8) (Po66 carbohydrate-binding protein) (Po66-CBP) (Prostate carcinoma tumor antigen 1) (PCTA-1)

Gene: LEG8, LGALS8
Organism: Homo sapiens
Interactions: 211
UniProt ID: O00214

Gene Ontology (top 5):
GO:0002317 - plasma cell differentiation
GO:0005178 - integrin binding
GO:0005615 - extracellular space
GO:0005737 - cytoplasm
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

127334

NECT1
Nectin-1

3

12

High-throughput

0.861

High

127350

CD276
CD276 antigen

3

7

High-throughput

0.861

High

127404

FPRP
Prostaglandin F2 receptor negative regulator

3

10

High-throughput

0.861

High

127298

MUC18
Cell surface glycoprotein MUC18

3

9

High-throughput

0.839

High

125066

LEG9
Galectin-9

2

15

Small-scale

0.789

High

127322

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

15

7

Small-scale

0.764

High

127364

TAXB1
Tax1-binding protein 1

9

7

Small-scale

0.756

High

127246

ITB1
Integrin beta-1

8

16

Small-scale

0.750

High

127281

ITA3
Integrin alpha-3

6

20

Small-scale

0.736

High

127253

ITA5
Integrin alpha-5

6

20

Small-scale

0.730

High

127265

ITA4
Integrin alpha-4

5

20

Small-scale

0.721

High

127399

NECT3
Nectin-3

2

18

High-throughput

0.705

High

127217

SDCB1
Syntenin-1

4

8

Small-scale

0.694

High

127308

ITA1
Integrin alpha-1

4

20

Small-scale

0.694

High

127410

S12A6
Solute carrier family 12 member 6

4

20

Small-scale

0.694

High

127401

S17A5
Sialin

4

2

High-throughput

0.691

High

127412

TRIM1
Probable E3 ubiquitin-protein ligase MID2

3

18

High-throughput

0.675

High

127293

TRI23
E3 ubiquitin-protein ligase TRIM23

3

2

Small-scale

0.669

High

127218

PODXL
Podocalyxin

3

6

High-throughput

0.667

High

127221

MRP4
ATP-binding cassette sub-family C member 4

3

13

High-throughput

0.667

High

127223

ADCY6
Adenylate cyclase type 6

3

9

High-throughput

0.667

High

127224

RNF13
E3 ubiquitin-protein ligase RNF13

3

4

High-throughput

0.667

High

127225

SUSD5
Sushi domain-containing protein 5

3

2

High-throughput

0.667

High

127227

ADCY9
Adenylate cyclase type 9

3

9

High-throughput

0.667

High

127239

FINC
Fibronectin

3

20

High-throughput

0.667

High

127245

B3A2
Anion exchange protein 2

3

10

High-throughput

0.667

High

127255

CD63
CD63 antigen

3

10

High-throughput

0.667

High

127257

CO4A
Complement C4-A

3

7

High-throughput

0.667

High

127260

PPAL
Lysosomal acid phosphatase

3

3

High-throughput

0.667

High

127272

ITA2
Integrin alpha-2

3

20

High-throughput

0.667

High

127273

PTPRA
Receptor-type tyrosine-protein phosphatase alpha

3

20

High-throughput

0.667

High

127274

LFA3
Lymphocyte function-associated antigen 3

3

3

High-throughput

0.667

High

127278

ITA6
Integrin alpha-6

3

20

High-throughput

0.667

High

127280

AT2B4
Plasma membrane calcium-transporting ATPase 4

3

11

High-throughput

0.667

High

127292

VGFR3
Vascular endothelial growth factor receptor 3

3

8

High-throughput

0.667

High

127297

EAA3
Excitatory amino acid transporter 3

3

7

High-throughput

0.667

High

127300

S26A2
Sulfate transporter

3

5

High-throughput

0.667

High

127302

CLCN3
H(+)/Cl(-) exchange transporter 3

3

9

High-throughput

0.667

High

127303

CLCN5
H(+)/Cl(-) exchange transporter 5

3

9

High-throughput

0.667

High

127304

CLCN7
H(+)/Cl(-) exchange transporter 7

3

9

High-throughput

0.667

High

127306

S12A2
Solute carrier family 12 member 2

3

20

High-throughput

0.667

High

127315

AT2B2
Plasma membrane calcium-transporting ATPase 2

3

9

High-throughput

0.667

High

127326

ITA7
Integrin alpha-7 [Cleaved into: Integrin alpha-7 heavy chain; Integrin alpha-7 light chain; Integrin alpha-7 70 kDa form]

3

20

High-throughput

0.667

High

127330

DAG1
Dystroglycan 1

3

5

High-throughput

0.667

High

127335

PTPRK
Receptor-type tyrosine-protein phosphatase kappa

3

20

High-throughput

0.667

High

127344

ANO6
Anoctamin-6

3

5

High-throughput

0.667

High

127346

COL12
Collectin-12

3

10

High-throughput

0.667

High

127349

RRAGB
Ras-related GTP-binding protein B

3

10

High-throughput

0.667

High

127354

LRC8E
Volume-regulated anion channel subunit LRRC8E

3

6

High-throughput

0.667

High

127361

ATG9A
Autophagy-related protein 9A

3

5

High-throughput

0.667

High

127365

OSTM1
Osteopetrosis-associated transmembrane protein 1

3

2

High-throughput

0.667

High

127369

LRC8A
Volume-regulated anion channel subunit LRRC8A

3

6

High-throughput

0.667

High

127371

K319L
Dyslexia-associated protein KIAA0319-like protein

3

3

High-throughput

0.667

High

127375

SPP2A
Signal peptide peptidase-like 2A

3

1

High-throughput

0.667

High

127376

TRPM4
Transient receptor potential cation channel subfamily M member 4

3

2

High-throughput

0.667

High

127378

LRC8C
Volume-regulated anion channel subunit LRRC8C

3

6

High-throughput

0.667

High

127382

SORL
Sortilin-related receptor

3

11

High-throughput

0.667

High

127392

S12A9
Solute carrier family 12 member 9

3

20

High-throughput

0.667

High

127395

AT133
Polyamine-transporting ATPase 13A3

3

13

High-throughput

0.667

High

127396

RRAGC
Ras-related GTP-binding protein C

3

10

High-throughput

0.667

High

127405

MRC2
C-type mannose receptor 2

3

20

High-throughput

0.667

High

127411

LCAP
Leucyl-cystinyl aminopeptidase

3

5

High-throughput

0.667

High

127416

S12A4
Solute carrier family 12 member 4

3

20

High-throughput

0.667

High

127421

ZNT1
Proton-coupled zinc antiporter SLC30A1

3

3

High-throughput

0.667

High

127422

S4A7
Sodium bicarbonate cotransporter 3

3

10

High-throughput

0.667

High

127423

ENPP4
Bis(5'-adenosyl)-triphosphatase ENPP4

3

4

High-throughput

0.667

High

127216

LEG8
Galectin-8

1

15

Small-scale

0.647

High

127387

CA159
Uncharacterized protein C1orf159

3

0

High-throughput

0.638

High

127388

TM237
Transmembrane protein 237

3

0

High-throughput

0.638

High

127347

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

2

1

Small-scale

0.629

High

127296

ECE1
Endothelin-converting enzyme 1

2

4

High-throughput

0.628

High

127267

ACPH
Acylamino-acid-releasing enzyme

2

3

High-throughput

0.628

High

127219

NPC1
NPC intracellular cholesterol transporter 1

2

2

High-throughput

0.611

High

127384

VPP1
V-type proton ATPase 116 kDa subunit a 1

2

8

High-throughput

0.611

High

50069

S22AN
Solute carrier family 22 member 23

3

4

High-throughput

0.609

High

127232

TM63A
Mechanosensitive cation channel TMEM63A

3

6

High-throughput

0.609

High

127279

PTPRG
Receptor-type tyrosine-protein phosphatase gamma

3

20

High-throughput

0.609

High

127307

MFAP3
Microfibril-associated glycoprotein 3

3

3

High-throughput

0.609

High

127319

CD47
Leukocyte surface antigen CD47

3

3

High-throughput

0.609

High

127320

PTPRJ
Receptor-type tyrosine-protein phosphatase eta

3

20

High-throughput

0.609

High

127327

CD166
CD166 antigen

3

13

High-throughput

0.609

High

127341

LAMA4
Laminin subunit alpha-4

3

19

High-throughput

0.609

High

127342

AT2B3
Plasma membrane calcium-transporting ATPase 3

3

11

High-throughput

0.609

High

127348

TM63B
Mechanosensitive cation channel TMEM63B

3

6

High-throughput

0.609

High

127356

EMB
Embigin

3

11

High-throughput

0.609

High

127357

CSPG4
Chondroitin sulfate proteoglycan 4

3

15

High-throughput

0.609

High

127358

SE6L2
Seizure 6-like protein 2

3

7

High-throughput

0.609

High

127359

SV2A
Synaptic vesicle glycoprotein 2A

3

4

High-throughput

0.609

High

127360

S36A1
Proton-coupled amino acid transporter 1

3

1

High-throughput

0.609

High

127363

SDK1
Protein sidekick-1

3

12

High-throughput

0.609

High

127373

S38A9
Neutral amino acid transporter 9

3

3

High-throughput

0.609

High

127381

SL9A6
Sodium/hydrogen exchanger 6

3

4

High-throughput

0.609

High

127397

K1549
UPF0606 protein KIAA1549

3

7

High-throughput

0.609

High

127413

HEG1
Protein HEG homolog 1

3

18

High-throughput

0.609

High

127417

VPP2
V-type proton ATPase 116 kDa subunit a 2

3

8

High-throughput

0.609

High

127420

S12A7
Solute carrier family 12 member 7

3

20

High-throughput

0.609

High

127385

WBP2
WW domain-binding protein 2

2

1

High-throughput

0.606

High

127389

NACC1
Nucleus accumbens-associated protein 1

2

2

High-throughput

0.606

High

127386

LIGO1
Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1

2

7

High-throughput

0.601

High

127380

GLMP
Glycosylated lysosomal membrane protein

2

0

High-throughput

0.585

High

127244

ERBB2
Receptor tyrosine-protein kinase erbB-2

2

6

High-throughput

0.576

High

127287

TNFL8
Tumor necrosis factor ligand superfamily member 8

2

0

High-throughput

0.576

High

127289

CD80
T-lymphocyte activation antigen CD80

1

9

High-throughput

0.575

High

127337

CD226
CD226 antigen

1

18

High-throughput

0.575

High

127402

LRC4B
Leucine-rich repeat-containing protein 4B

2

9

High-throughput

0.574

High

127241

ESR1
Estrogen receptor

2

7

High-throughput

0.571

High

127290

CD68
Macrosialin

2

10

Small-scale

0.571

High

127243

ANXA1
Annexin A1

2

10

Small-scale

0.563

High

127390

BARD1
BRCA1-associated RING domain protein 1

1

2

High-throughput

0.552

High

127233

NPT2B
Sodium-dependent phosphate transport protein 2B

2

2

High-throughput

0.552

High

127419

NPTN
Neuroplastin

2

11

High-throughput

0.549

High

127230

DJC13
DnaJ homolog subfamily C member 13

1

3

High-throughput

0.536

High

127270

CD44
CD44 antigen

1

6

High-throughput

0.536

High

127271

LEUK
Leukosialin

1

2

High-throughput

0.536

High

127288

MRP1
Multidrug resistance-associated protein 1

1

13

High-throughput

0.536

High

127352

SIGIR
Single Ig IL-1-related receptor

1

1

High-throughput

0.536

High

127372

S15A4
Solute carrier family 15 member 4

1

7

Small-scale

0.536

High

127408

TBK1
Serine/threonine-protein kinase TBK1

1

2

High-throughput

0.536

High

127409

GT2D1
General transcription factor II-I repeat domain-containing protein 1

1

2

High-throughput

0.536

High

127414

ICAM5
Intercellular adhesion molecule 5

1

9

High-throughput

0.536

High

127283

CALR
Calreticulin

1

4

High-throughput

0.515

High

127294

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

3

High-throughput

0.515

High

127379

NEK7
Serine/threonine-protein kinase Nek7

1

2

High-throughput

0.515

High

127229

SCN2B
Sodium channel regulatory subunit beta-2

1

13

High-throughput

0.514

High

127366

VSIG1
V-set and immunoglobulin domain-containing protein 1

1

11

High-throughput

0.514

High

127377

HAVR2
Hepatitis A virus cellular receptor 2

1

2

High-throughput

0.514

High

127325

CUL1
Cullin-1

1

0

High-throughput

0.513

High

127222

MEFV
Pyrin

1

13

Small-scale

0.501

High

127258

TRI49
Tripartite motif-containing protein 49

1

14

Small-scale

0.501

High

127324

G3BP1
Ras GTPase-activating protein-binding protein 1

1

2

Small-scale

0.501

High

127362

NUFP2
FMR1-interacting protein NUFIP2

1

1

Small-scale

0.501

High

127370

TRI22
E3 ubiquitin-protein ligase TRIM22

1

14

Small-scale

0.501

High

127393

TRIM6
Tripartite motif-containing protein 6

1

14

Small-scale

0.501

High

127394

TRIM5
Tripartite motif-containing protein 5

1

14

Small-scale

0.501

High

127418

TRI17
E3 ubiquitin-protein ligase TRIM17

1

13

Small-scale

0.501

High

127374

VANG1
Vang-like protein 1

1

1

High-throughput

0.489

High

127403

PAPD1
Poly(A) RNA polymerase, mitochondrial

1

1

High-throughput

0.489

High

127332

NR1D2
Nuclear receptor subfamily 1 group D member 2

1

7

High-throughput

0.481

High

127235

EGFR
Epidermal growth factor receptor

1

6

High-throughput

0.479

High

127236

A2MG
Alpha-2-macroglobulin

1

7

Small-scale

0.479

High

127237

APOA1
Apolipoprotein A-I

1

3

Small-scale

0.479

High

127240

HEMO
Hemopexin

1

5

Small-scale

0.479

High

127242

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

3

High-throughput

0.479

High

127247

ITAV
Integrin alpha-V

1

20

Small-scale

0.479

High

127248

PDIA1
Protein disulfide-isomerase

1

6

Small-scale

0.479

High

127249

ANXA2
Annexin A2

1

8

Small-scale

0.479

High

127250

HS90A
Heat shock protein HSP 90-alpha

1

5

Small-scale

0.479

High

127251

RHOC
Rho-related GTP-binding protein RhoC

1

5

Small-scale

0.479

High

127252

MMP3
Stromelysin-1

1

6

Small-scale

0.479

High

127254

ANXA5
Annexin A5

1

10

Small-scale

0.479

High

127256

HMGB1
High mobility group protein B1

1

5

Small-scale

0.479

High

127259

THIO
Thioredoxin

1

5

Small-scale

0.479

High

127262

LAMP1
Lysosome-associated membrane glycoprotein 1

1

10

Small-scale

0.479

High

127263

FGFR1
Fibroblast growth factor receptor 1

1

7

High-throughput

0.479

High

127264

LAMP2
Lysosome-associated membrane glycoprotein 2

1

10

Small-scale

0.479

High

127266

PDIA4
Protein disulfide-isomerase A4

1

6

Small-scale

0.479

High

127268

ENPL
Endoplasmin

1

5

Small-scale

0.479

High

127269

MMP9
Matrix metalloproteinase-9

1

16

Small-scale

0.479

High

127276

BTF3
Transcription factor BTF3

1

1

High-throughput

0.479

High

127277

ITAL
Integrin alpha-L

1

20

Small-scale

0.479

High

127282

HMGB2
High mobility group protein B2

1

5

Small-scale

0.479

High

127284

CALX
Calnexin

1

4

Small-scale

0.479

High

127285

GDIA
Rab GDP dissociation inhibitor alpha

1

1

Small-scale

0.479

High

127286

PRDX2
Peroxiredoxin-2

1

6

Small-scale

0.479

High

127301

RAB7A
Ras-related protein Rab-7a

1

2

Small-scale

0.479

High

127309

CDC42
Cell division control protein 42 homolog

1

5

Small-scale

0.479

High

127310

RAB14
Ras-related protein Rab-14

1

6

Small-scale

0.479

High

127312

1433G
14-3-3 protein gamma

1

8

Small-scale

0.479

High

127313

1433E
14-3-3 protein epsilon

1

1

Small-scale

0.479

High

127317

PRDX1
Peroxiredoxin-1

1

6

Small-scale

0.479

High

127318

LG3BP
Galectin-3-binding protein

1

5

Small-scale

0.479

High

127328

SPTN1
Spectrin alpha chain, non-erythrocytic 1

1

7

High-throughput

0.479

High

127329

SCRB2
Lysosome membrane protein 2

1

3

High-throughput

0.479

High

127333

PDIA6
Protein disulfide-isomerase A6

1

6

Small-scale

0.479

High

127345

PAN2
PAN2-PAN3 deadenylation complex catalytic subunit PAN2

1

2

High-throughput

0.479

High

127400

ANLN
Anillin

1

1

High-throughput

0.479

High

127406

HDAC6
Protein deacetylase HDAC6

1

2

High-throughput

0.479

High

127355

Q6NSM0
NR1D2 protein

1

10

High-throughput

0.470

High

127226

NUPR1
Nuclear protein 1

1

0

High-throughput

0.458

High

127234

SODC
Superoxide dismutase [Cu-Zn]

1

0

Small-scale

0.458

High

127305

GDIR1
Rho GDP-dissociation inhibitor 1

1

0

Small-scale

0.458

High

127311

LYSC
Lysozyme C

1

0

Small-scale

0.458

High

127314

NDP
Norrin

1

0

Small-scale

0.458

High

127367

PDPN
Podoplanin

1

0

Small-scale

0.458

High

127407

CATZ
Cathepsin Z

1

0

Small-scale

0.458

High

127415

EPCR
Endothelial protein C receptor

1

0

High-throughput

0.458

High

127261

GTR1
Solute carrier family 2, facilitated glucose transporter member 1

1

4

High-throughput

0.445

High

127291

BMI1
Polycomb complex protein BMI-1

1

14

High-throughput

0.445

High

127295

PK3CA
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

1

1

High-throughput

0.445

High

127299

S6A12
Sodium- and chloride-dependent betaine transporter

1

8

High-throughput

0.445

High

127316

VMAT2
Synaptic vesicular amine transporter

1

6

High-throughput

0.445

High

127323

S13A2
Solute carrier family 13 member 2

1

2

High-throughput

0.445

High

127343

MICB
MHC class I polypeptide-related sequence B

1

1

High-throughput

0.445

High

127353

PKHA7
Pleckstrin homology domain-containing family A member 7

1

2

High-throughput

0.445

High

127321

PDIA2
Protein disulfide-isomerase A2

1

4

Small-scale

0.437

High

127331

ITIH4
Inter-alpha-trypsin inhibitor heavy chain H4

1

2

Small-scale

0.437

High

127338

EZH2
Histone-lysine N-methyltransferase EZH2

1

2

High-throughput

0.437

High

127351

NR3L1
Natural cytotoxicity triggering receptor 3 ligand 1

1

15

High-throughput

0.437

High

127383

ESR2
Estrogen receptor beta

1

5

High-throughput

0.437

High

127238

GLPA
Glycophorin-A

1

0

High-throughput

0.426

High

127339

NF2L2
Nuclear factor erythroid 2-related factor 2

1

0

High-throughput

0.426

High

127228

RAMP3
Receptor activity-modifying protein 3

1

1

High-throughput

0.407

High

127275

CD53
Leukocyte surface antigen CD53

1

11

High-throughput

0.407

High

127340

S15A2
Solute carrier family 15 member 2

1

7

High-throughput

0.407

High

127368

S22A9
Organic anion transporter 7

1

4

High-throughput

0.407

High

127398

SO1B3
Solute carrier organic anion transporter family member 1B3

1

4

High-throughput

0.407

High

127220

COPT1
High affinity copper uptake protein 1

3

0

High-throughput

0.347

High

127391

S35A5
UDP-sugar transporter protein SLC35A5

3

0

High-throughput

0.347

High

127336

TGIF1
Homeobox protein TGIF1

1

0

Small-scale

0.276

Low

127231

WFS1
Wolframin

1

0

High-throughput

0.268

Low


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Last updated: 11Aug2025