HitPredict

Interactor 1: SPP2B (Q8TCT7)
Signal peptide peptidase-like 2B (SPP-like 2B) (SPPL2b) (EC 3.4.23.-) (Intramembrane protease 4) (IMP-4) (Presenilin homologous protein 4) (PSH4) (Presenilin-like protein 1)
Gene: SPPL2B

Interactor 2: 5HT3C (Q8WXA8)
5-hydroxytryptamine receptor 3C (5-HT3-C) (5-HT3C) (Serotonin receptor 3C)
Gene: HTR3C

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.667

Property	Details
Experiments	26186194, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 592 Hs			1 447
+	Hs
		677155 SPP2B_HUMAN (25-592): 0: 704: 100.00		ACHB4_HUMAN (7-442): 1.84e-139: 410: 19.18
+	Hs
		798539 SPP2B_HUMAN (25-592): 0: 704: 100.00		ACHA4_HUMAN (30-399): 2.48e-135: 404: 24.27
+	Hs
		570866 SPP2B_HUMAN (25-592): 0: 704: 100.00		ACHB2_HUMAN (36-442): 1.38e-135: 400: 21.13
+	Hs
		802361 SPP2B_HUMAN (25-592): 0: 704: 100.00		5HT3A_HUMAN (31-446): 8.08e-129: 382: 34.00
+	Hs
		989634 SPP2B_HUMAN (25-592): 0: 704: 100.00		ACHD_HUMAN (36-373): 5.05e-121: 364: 25.93
+	Hs
		798538 SPPL3_HUMAN (162-509): 3.71e-104: 321: 23.76		ACHA4_HUMAN (30-399): 2.48e-135: 404: 24.27
+	Hs
		570865 SPPL3_HUMAN (162-509): 3.71e-104: 321: 23.76		ACHB2_HUMAN (36-442): 1.38e-135: 400: 21.13
+	Hs
		802360 SPPL3_HUMAN (162-509): 3.71e-104: 321: 23.76		5HT3A_HUMAN (31-446): 8.08e-129: 382: 34.00
+	Hs
		989633 SPPL3_HUMAN (162-509): 3.71e-104: 321: 23.76		ACHD_HUMAN (36-373): 5.05e-121: 364: 25.93