Protein: EP400
E1A-binding protein p400 (EC 3.6.4.-) (CAG repeat protein 32) (Domino homolog) (hDomino) (Trinucleotide repeat-containing gene 12 protein) (p400 kDa SWI2/SNF2-related protein)

Gene: EP400
Organism: Homo sapiens
Interactions: 178
UniProt ID: Q96L91

Gene Ontology (top 5):
GO:0000786 - nucleosome
GO:0000812 - Swr1 complex
GO:0003677 - DNA binding
GO:0003682 - chromatin binding
GO:0004386 - helicase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1396761

RUVB1
RuvB-like 1

8

20

Small-scale

0.972

High

1396760

RUVB2
RuvB-like 2

9

20

Small-scale

0.970

High

502095

H2AZ
Histone H2A.Z

5

20

Small-scale

0.919

High

1381844

H2B1A
Histone H2B type 1-A

4

20

High-throughput

0.892

High

1396750

DMAP1
DNA methyltransferase 1-associated protein 1

4

8

Small-scale

0.886

High

1371243

KAT5
Histone acetyltransferase KAT5

12

9

Small-scale

0.757

High

372862

MYC
Myc proto-oncogene protein

10

20

Small-scale

0.756

High

355280

ACL6A
Actin-like protein 6A

2

20

Small-scale

0.754

High

980158

H4
Histone H4

2

17

High-throughput

0.754

High

981019

H2B1C
Histone H2B type 1-C/E/F/G/I

2

20

High-throughput

0.754

High

1396755

MO4L1
Mortality factor 4-like protein 1

9

5

Small-scale

0.749

High

1155316

VPS72
Vacuolar protein sorting-associated protein 72 homolog

2

4

Small-scale

0.737

High

340388

YETS4
YEATS domain-containing protein 4

6

10

Small-scale

0.733

High

1396740

BRD8
Bromodomain-containing protein 8

6

20

Small-scale

0.732

High

1136840

MO4L2
Mortality factor 4-like protein 2

6

5

Small-scale

0.729

High

1396751

MRGBP
MRG/MORF4L-binding protein

6

3

Small-scale

0.727

High

959636

MAX
Protein max

5

20

Small-scale

0.718

High

1396764

TRRAP
Transformation/transcription domain-associated protein

5

13

Small-scale

0.714

High

1245357

FOXR2
Forkhead box protein R2

4

20

High-throughput

0.699

High

953042

ACTB
Actin, cytoplasmic 1

1

20

High-throughput

0.691

High

993296

ACTG
Actin, cytoplasmic 2

1

20

High-throughput

0.691

High

1163143

H2B2E
Histone H2B type 2-E

1

20

High-throughput

0.691

High

1323958

H2B3B
Histone H2B type 3-B

1

20

High-throughput

0.691

High

560903

HEM1
5-aminolevulinate synthase, non-specific, mitochondrial

3

2

High-throughput

0.674

High

553760

MYCL
Protein L-Myc

3

20

Small-scale

0.667

High

419141

H2A1B
Histone H2A type 1-B/E

1

20

High-throughput

0.665

High

995770

ACTC
Actin, alpha cardiac muscle 1

1

20

High-throughput

0.665

High

913159

STAT2
Signal transducer and activator of transcription 2

3

6

High-throughput

0.662

High

1396747

EAF6
Chromatin modification-related protein MEAF6

4

0

Small-scale

0.661

High

1053305

MBTD1
MBT domain-containing protein 1

3

6

Small-scale

0.656

High

1291978

JAZF1
Juxtaposed with another zinc finger protein 1

3

1

Small-scale

0.656

High

396732

ESR1
Estrogen receptor

3

20

High-throughput

0.640

High

1244933

FOXR1
Forkhead box protein R1

4

20

High-throughput

0.638

High

1396763

DYR1B
Dual specificity tyrosine-phosphorylation-regulated kinase 1B

2

5

High-throughput

0.628

High

180360

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

1

6

High-throughput

0.621

High

1327443

ZGPAT
Zinc finger CCCH-type with G patch domain-containing protein

1

3

High-throughput

0.621

High

285419

EED
Polycomb protein EED

1

20

High-throughput

0.618

High

317363

ACL6B
Actin-like protein 6B

1

20

Small-scale

0.618

High

754944

H2B1B
Histone H2B type 1-B

1

20

High-throughput

0.618

High

937321

DSRAD
Double-stranded RNA-specific adenosine deaminase

1

19

High-throughput

0.618

High

1097496

CBX3
Chromobox protein homolog 3

1

20

High-throughput

0.618

High

1119596

NFYC
Nuclear transcription factor Y subunit gamma

1

4

High-throughput

0.618

High

1158961

RBBP7
Histone-binding protein RBBP7

1

20

High-throughput

0.618

High

1338904

NUP43
Nucleoporin Nup43

1

20

High-throughput

0.618

High

1380090

FBXW7
F-box/WD repeat-containing protein 7

1

9

Small-scale

0.618

High

1387495

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

14

High-throughput

0.618

High

1396744

WDR76
WD repeat-containing protein 76

1

20

High-throughput

0.618

High

487641

PARP1
Poly [ADP-ribose] polymerase 1

2

20

Small-scale

0.611

High

872642

SOX2
Transcription factor SOX-2

2

20

Small-scale

0.611

High

1198108

EPC2
Enhancer of polycomb homolog 2

2

3

Small-scale

0.611

High

1396742

EPC1
Enhancer of polycomb homolog 1

2

2

Small-scale

0.611

High

1396752

ING3
Inhibitor of growth protein 3

2

6

Small-scale

0.611

High

911343

IMA5
Importin subunit alpha-5

2

20

High-throughput

0.601

High

370760

FOS
Protein c-Fos

2

11

High-throughput

0.584

High

406516

MYCN
N-myc proto-oncogene protein

2

20

Small-scale

0.584

High

414424

P53
Cellular tumor antigen p53

2

10

Small-scale

0.584

High

764969

CTNB1
Catenin beta-1

2

20

Small-scale

0.584

High

1314367

SLX4
Structure-specific endonuclease subunit SLX4

2

12

High-throughput

0.584

High

1396735

SSX3
Protein SSX3

2

6

High-throughput

0.574

High

1055956

RAD51
DNA repair protein RAD51 homolog 1

1

3

Small-scale

0.561

High

1102227

ATM
Serine-protein kinase ATM

1

13

Small-scale

0.561

High

1198198

PDCD4
Programmed cell death protein 4

1

3

High-throughput

0.553

High

1255110

TRI67
Tripartite motif-containing protein 67

1

14

High-throughput

0.553

High

542164

TOP1
DNA topoisomerase 1

1

8

High-throughput

0.536

High

625564

CSK22
Casein kinase II subunit alpha'

1

13

High-throughput

0.536

High

833769

KDM5C
Lysine-specific demethylase 5C

1

15

High-throughput

0.536

High

854231

KI67
Proliferation marker protein Ki-67

1

10

High-throughput

0.536

High

1361570

ING5
Inhibitor of growth protein 5

1

3

High-throughput

0.536

High

1133611

NFIX
Nuclear factor 1 X-type

2

20

High-throughput

0.533

High

887132

CEBPA
CCAAT/enhancer-binding protein alpha

1

15

High-throughput

0.527

High

1396756

TRI10
Tripartite motif-containing protein 10

1

2

High-throughput

0.514

High

261544

B4GT2
Beta-1,4-galactosyltransferase 2

1

0

High-throughput

0.513

High

1123082

FHL2
Four and a half LIM domains protein 2

1

0

High-throughput

0.513

High

964418

SUMO2
Small ubiquitin-related modifier 2

1

15

High-throughput

0.501

High

457622

TBB5
Tubulin beta chain

1

2

High-throughput

0.489

High

1351820

CGAT1
Chondroitin sulfate N-acetylgalactosaminyltransferase 1

1

1

High-throughput

0.489

High

1090858

TRAF2
TNF receptor-associated factor 2

1

4

High-throughput

0.481

High

1337460

MNS1
Meiosis-specific nuclear structural protein 1

1

1

High-throughput

0.481

High

129340

MEN1
Menin

1

7

High-throughput

0.479

High

130581

SPT5H
Transcription elongation factor SPT5

1

10

High-throughput

0.479

High

143197

NFIB
Nuclear factor 1 B-type

1

20

High-throughput

0.479

High

157739

CTRO
Citron Rho-interacting kinase

1

8

High-throughput

0.479

High

191053

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

11

High-throughput

0.479

High

210091

CRX
Cone-rod homeobox protein

1

20

High-throughput

0.479

High

260316

BRD4
Bromodomain-containing protein 4

1

20

High-throughput

0.479

High

339828

KLF8
Krueppel-like factor 8

1

20

High-throughput

0.479

High

401316

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

9

High-throughput

0.479

High

474217

NFIC
Nuclear factor 1 C-type

1

20

High-throughput

0.479

High

520300

ANDR
Androgen receptor

1

20

High-throughput

0.479

High

538458

EGR2
E3 SUMO-protein ligase EGR2

1

9

High-throughput

0.479

High

558335

XRCC6
X-ray repair cross-complementing protein 6

1

10

High-throughput

0.479

High

577488

ETS1
Protein C-ets-1

1

20

High-throughput

0.479

High

581717

MYOD1
Myoblast determination protein 1

1

14

High-throughput

0.479

High

589436

RFA2
Replication protein A 32 kDa subunit

1

9

High-throughput

0.479

High

596302

H12
Histone H1.2

1

5

High-throughput

0.479

High

640265

EPHA1
Ephrin type-A receptor 1

1

3

High-throughput

0.479

High

675632

TYY1
Transcriptional repressor protein YY1

1

20

High-throughput

0.479

High

685314

PAX6
Paired box protein Pax-6

1

13

High-throughput

0.479

High

696242

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

13

High-throughput

0.479

High

697222

APEX1
DNA repair nuclease/redox regulator APEX1

1

5

High-throughput

0.479

High

714359

PML
Protein PML

1

19

High-throughput

0.479

High

717941

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

1

3

Small-scale

0.479

High

739019

ELF1
ETS-related transcription factor Elf-1

1

20

High-throughput

0.479

High

749491

C2TA
MHC class II transactivator

1

4

Small-scale

0.479

High

768920

RFA3
Replication protein A 14 kDa subunit

1

7

High-throughput

0.479

High

775900

HNF1B
Hepatocyte nuclear factor 1-beta

1

18

High-throughput

0.479

High

834034

HNF4A
Hepatocyte nuclear factor 4-alpha

1

20

High-throughput

0.479

High

837079

ELK3
ETS domain-containing protein Elk-3

1

20

High-throughput

0.479

High

851640

GATA4
Transcription factor GATA-4

1

20

High-throughput

0.479

High

873119

SOX9
Transcription factor SOX-9

1

20

High-throughput

0.479

High

879369

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

20

High-throughput

0.479

High

895780

LHX2
LIM/homeobox protein Lhx2

1

13

High-throughput

0.479

High

905044

MECP2
Methyl-CpG-binding protein 2

1

20

High-throughput

0.479

High

944724

KLF3
Krueppel-like factor 3

1

20

High-throughput

0.479

High

995202

CSK2B
Casein kinase II subunit beta

1

7

High-throughput

0.479

High

1026513

HSF1
Heat shock factor protein 1

1

5

High-throughput

0.479

High

1033749

PO5F1
POU domain, class 5, transcription factor 1

1

16

High-throughput

0.479

High

1057471

SOX4
Transcription factor SOX-4

1

20

High-throughput

0.479

High

1087952

NFIA
Nuclear factor 1 A-type

1

20

High-throughput

0.479

High

1088973

TP53B
TP53-binding protein 1

1

9

High-throughput

0.479

High

1103321

CTBP1
C-terminal-binding protein 1

1

2

High-throughput

0.479

High

1114023

CUL3
Cullin-3

1

11

High-throughput

0.479

High

1118759

KLF5
Krueppel-like factor 5

1

20

High-throughput

0.479

High

1137462

SUZ12
Polycomb protein SUZ12

1

8

High-throughput

0.479

High

1146257

ZMY11
Zinc finger MYND domain-containing protein 11

1

20

Small-scale

0.479

High

1152728

ELF2
ETS-related transcription factor Elf-2

1

20

High-throughput

0.479

High

1155671

EZH2
Histone-lysine N-methyltransferase EZH2

1

20

High-throughput

0.479

High

1161364

HIF1A
Hypoxia-inducible factor 1-alpha

1

10

High-throughput

0.479

High

1289544

NAA40
N-alpha-acetyltransferase 40

1

4

High-throughput

0.479

High

1313343

SMC5
Structural maintenance of chromosomes protein 5

1

10

High-throughput

0.479

High

1329815

SIR6
NAD-dependent protein deacylase sirtuin-6

1

12

High-throughput

0.479

High

1351128

SP7
Transcription factor Sp7

1

20

High-throughput

0.479

High

1396731

CIC
Protein capicua homolog

1

20

High-throughput

0.479

High

1396732

FEV
Protein FEV

1

20

High-throughput

0.479

High

1396733

ELF4
ETS-related transcription factor Elf-4

1

20

High-throughput

0.479

High

1396734

KLF6
Krueppel-like factor 6

1

20

High-throughput

0.479

High

1396739

WWTR1
WW domain-containing transcription regulator protein 1

1

17

High-throughput

0.479

High

1396741

CCDC8
Coiled-coil domain-containing protein 8

1

3

High-throughput

0.479

High

1396745

NANOG
Homeobox protein NANOG

1

20

High-throughput

0.479

High

1396753

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

5

High-throughput

0.479

High

1396758

KLF15
Krueppel-like factor 15

1

20

High-throughput

0.479

High

1396759

MED23
Mediator of RNA polymerase II transcription subunit 23

1

1

High-throughput

0.479

High

1396762

ASF1A
Histone chaperone ASF1A

1

12

High-throughput

0.479

High

1396765

KLF12
Krueppel-like factor 12

1

20

High-throughput

0.479

High

247155

TBCD4
TBC1 domain family member 4

1

2

Small-scale

0.464

High

1294812

STX12
Syntaxin-12

1

0

High-throughput

0.458

High

1396736

AN32E
Acidic leucine-rich nuclear phosphoprotein 32 family member E

1

4

Small-scale

0.445

High

1392845

NTAQ1
Protein N-terminal glutamine amidohydrolase

1

1

High-throughput

0.439

High

272393

OBSL1
Obscurin-like protein 1

1

6

High-throughput

0.437

High

718161

2AAB
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform

1

3

Small-scale

0.437

High

977566

PP2AB
Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform

1

3

Small-scale

0.437

High

986639

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

5

High-throughput

0.437

High

994340

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

1

3

Small-scale

0.437

High

1024771

VIGLN
Vigilin

1

12

High-throughput

0.437

High

1037882

HEN1
Helix-loop-helix protein 1

1

15

High-throughput

0.437

High

1052902

HME1
Homeobox protein engrailed-1

1

7

High-throughput

0.437

High

1120950

TRI29
Tripartite motif-containing protein 29

1

5

Small-scale

0.437

High

1241931

FBX42
F-box only protein 42

1

3

High-throughput

0.437

High

1244817

FBX38
F-box only protein 38

1

1

High-throughput

0.437

High

1276652

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

9

High-throughput

0.437

High

1396737

CP250
Centrosome-associated protein CEP250

1

11

High-throughput

0.437

High

1396738

KLF16
Krueppel-like factor 16

1

20

High-throughput

0.437

High

1396743

PKHA4
Pleckstrin homology domain-containing family A member 4

1

17

High-throughput

0.437

High

1396754

HECW2
E3 ubiquitin-protein ligase HECW2

1

6

High-throughput

0.437

High

1396757

XPO7
Exportin-7

1

3

High-throughput

0.437

High

1316962

FAM9B
Protein FAM9B

1

0

High-throughput

0.426

High

1185863

NSN5B
Putative NOL1/NOP2/Sun domain family member 5B

1

1

High-throughput

0.407

High

1199653

KLH22
Kelch-like protein 22

1

4

High-throughput

0.407

High

1335679

MOT11
Monocarboxylate transporter 11

1

1

High-throughput

0.407

High

1396746

LN28A
Protein lin-28 homolog A

1

3

High-throughput

0.407

High

1396749

RAB18
Ras-related protein Rab-18

1

2

High-throughput

0.407

High

1396748

PLAC1
Placenta-specific protein 1

3

0

High-throughput

0.347

High

1230801

ANR40
Ankyrin repeat domain-containing protein 40

1

0

High-throughput

0.279

Low

299336

FLOT1
Flotillin-1

1

0

High-throughput

0.249

Low

378514

IL1A
Interleukin-1 alpha

1

0

Small-scale

0.249

Low

827247

ARL1
ADP-ribosylation factor-like protein 1

1

0

High-throughput

0.249

Low

1213459

DCA12
DDB1- and CUL4-associated factor 12

1

0

High-throughput

0.249

Low

1395015

SPTCS
Spatacsin

1

0

Small-scale

0.238

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025