HitPredict

Interactor 1: WWP2 (O00308)
NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 2.3.2.26) (Atrophin-1-interacting protein 2) (AIP2) (HECT-type E3 ubiquitin transferase WWP2) (WW domain-containing protein 2)
Gene: WWP2

Interactor 2: ZO1 (Q07157)
Tight junction protein ZO-1 (Tight junction protein 1) (Zona occludens protein 1) (Zonula occludens protein 1)
Gene: TJP1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	31048545, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 870 Hs			1 1748
+	Dm
		1367280 SUDX_DROME (14-870): 0: 852: 52.14		Q9VHK4_DROME (14-1358): 1.93e-170: 556: 26.59
+	Dm
		1367276 NEDD4_DROME (5-868): 0: 734: 29.57		Q9VHK4_DROME (14-1358): 1.93e-170: 556: 26.59
+	Hs
		125577 WWP2_HUMAN (1-870): 0: 982: 100.00		PALS1_HUMAN (272-806): 1.75e-82: 288: 15.67
+	Hs
		1232500 WWP1_HUMAN (1-870): 0: 888: 58.38		PALS1_HUMAN (272-806): 1.75e-82: 288: 15.67
+	Hs
		125592 WWP2_HUMAN (1-870): 0: 982: 100.00		INADL_HUMAN (60-583): 5.65e-19: 96.5: 18.77
+	Hs
		808185 NEDD4_HUMAN (90-867): 0: 731: 35.94		PALS1_HUMAN (272-806): 1.75e-82: 288: 15.67
+	Hs
		1246432 WWP1_HUMAN (1-870): 0: 888: 58.38		INADL_HUMAN (60-583): 5.65e-19: 96.5: 18.77
+	Hs
		1271021 NED4L_HUMAN (5-867): 0: 785: 32.17		DLG3_HUMAN (21-427): 4.69e-51: 197: 17.51
+	Hs
		1327931 WWP1_HUMAN (1-870): 0: 888: 58.38		ZO2_HUMAN (391-610): 1e-09: 65.7: 17.98
+	Mm
		1143429 NED4L_MOUSE (4-867): 0: 781: 31.91		DLG4_MOUSE (1-112): 2.37e-27: 122: 29.92
+	Mm
		93267 E9PXB7_MOUSE (151-867): 0: 684: 37.10		DLG3_MOUSE (21-396): 1.29e-48: 190: 18.65
+	Mm
		93273 E9PXB7_MOUSE (151-867): 0: 684: 37.10		DLG4_MOUSE (1-112): 2.37e-27: 122: 29.92
+	Hs
		1021523 HUWE1_HUMAN (241-869): 7.77e-179: 575: 30.03		DLG1_HUMAN (263-512): 3.61e-17: 90: 16.54
+	Mm
		808344 NEDD4_MOUSE (14-364): 2.31e-51: 196: 19.16		DLG3_MOUSE (21-396): 1.29e-48: 190: 18.65