HitPredict

Interactor 1: WWP2 (O00308)
NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 2.3.2.26) (Atrophin-1-interacting protein 2) (AIP2) (HECT-type E3 ubiquitin transferase WWP2) (WW domain-containing protein 2)
Gene: WWP2

Interactor 2: RBBP4 (Q09028)
Histone-binding protein RBBP4 (Chromatin assembly factor 1 subunit C) (CAF-1 subunit C) (Chromatin assembly factor I p48 subunit) (CAF-I 48 kDa subunit) (CAF-I p48) (Nucleosome-remodeling factor subunit RBAP48) (Retinoblastoma-binding protein 4) (RBBP-4) (Retinoblastoma-binding protein p48)
Gene: RBBP4

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	31048545
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005829 - cytosol GO:0045892 - negative regulation of DNA-templated transcription
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 870 Hs			1 425
+	Hs
		125310 WWP2_HUMAN (1-870): 0: 982: 100.00		WDR5_HUMAN (267-425): 7.48e-35: 133: 25.61
+	Hs
		125681 WWP2_HUMAN (1-870): 0: 982: 100.00		GRWD1_HUMAN (263-425): 3.54e-26: 111: 23.56
+	Hs
		997784 HUWE1_HUMAN (241-869): 7.77e-179: 575: 30.03		RBBP4_HUMAN (1-425): 4.3e-124: 367: 100.00
+	Hs
		1083295 HUWE1_HUMAN (241-869): 7.77e-179: 575: 30.03		RBBP7_HUMAN (1-425): 3.63e-115: 345: 89.20
+	Hs
		1192190 HUWE1_HUMAN (241-869): 7.77e-179: 575: 30.03		GRWD1_HUMAN (263-425): 3.54e-26: 111: 23.56
+	Hs
		1223643 HACE1_HUMAN (374-864): 5.08e-160: 492: 31.05		GRWD1_HUMAN (263-425): 3.54e-26: 111: 23.56
+	Hs
		267800 HECW2_HUMAN (154-531): 5.96e-16: 84.8: 17.23		TAF5L_HUMAN (26-422): 3e-74: 244: 22.20