HitPredict

Interactor 1: WWP2 (O00308)
NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 2.3.2.26) (Atrophin-1-interacting protein 2) (AIP2) (HECT-type E3 ubiquitin transferase WWP2) (WW domain-containing protein 2)
Gene: WWP2

Interactor 2: PCBP1 (Q15365)
Poly(rC)-binding protein 1 (Alpha-CP1) (Heterogeneous nuclear ribonucleoprotein E1) (hnRNP E1) (Nucleic acid-binding protein SUB2.3)
Gene: PCBP1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	27684187, 31048545
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0016020 - membrane GO:0045944 - positive regulation of transcription by RNA polymerase II and 1 others more... GO:0070062 - extracellular exosome
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 870 Hs			1 356
+	Hs
		125473 WWP2_HUMAN (1-870): 0: 982: 100.00		PCBP2_HUMAN (1-352): 1.2e-97: 295: 81.44
+	Hs
		1072012 WWP1_HUMAN (1-870): 0: 888: 58.38		PCBP1_HUMAN (1-356): 2.47e-107: 320: 100.00
+	Hs
		125311 WWP2_HUMAN (1-870): 0: 982: 100.00		HNRPK_HUMAN (7-353): 1.94e-68: 223: 22.51
+	Hs
		1072159 ITCH_HUMAN (1-870): 0: 902: 54.26		PCBP2_HUMAN (1-352): 1.2e-97: 295: 81.44
+	Hs
		904128 WWP1_HUMAN (1-870): 0: 888: 58.38		HNRPK_HUMAN (7-353): 1.94e-68: 223: 22.51
+	Hs
		125622 WWP2_HUMAN (1-870): 0: 982: 100.00		FUBP2_HUMAN (237-352): 3.22e-13: 72.5: 26.72
+	Hs
		125820 WWP2_HUMAN (1-870): 0: 982: 100.00		IF2B2_HUMAN (237-350): 8.67e-09: 59: 17.39
+	Hs
		808075 NEDD4_HUMAN (90-867): 0: 731: 35.94		HNRPK_HUMAN (7-353): 1.94e-68: 223: 22.51
+	Hs
		1071920 HUWE1_HUMAN (241-869): 7.77e-179: 575: 30.03		PCBP1_HUMAN (1-356): 2.47e-107: 320: 100.00
+	Hs
		1072123 HUWE1_HUMAN (241-869): 7.77e-179: 575: 30.03		PCBP2_HUMAN (1-352): 1.2e-97: 295: 81.44
+	Hs
		904013 HUWE1_HUMAN (241-869): 7.77e-179: 575: 30.03		HNRPK_HUMAN (7-353): 1.94e-68: 223: 22.51
+	Hs
		1192151 HUWE1_HUMAN (241-869): 7.77e-179: 575: 30.03		FUBP2_HUMAN (237-352): 3.22e-13: 72.5: 26.72
+	Hs
		1072029 SMUF1_HUMAN (1-385): 1.35e-45: 177: 17.77		PCBP1_HUMAN (1-356): 2.47e-107: 320: 100.00
+	Hs
		904148 SMUF1_HUMAN (1-385): 1.35e-45: 177: 17.77		HNRPK_HUMAN (7-353): 1.94e-68: 223: 22.51
+	Hs
		1283851 SMUF2_HUMAN (1-363): 5.89e-43: 169: 17.62		FUBP1_HUMAN (224-352): 2.53e-13: 72.9: 22.48