Protein: PDK3
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 3)

Gene: PDK3
Organism: Homo sapiens
Interactions: 116
UniProt ID: Q15120

Gene Ontology (top 5):
GO:0004672 - protein kinase activity
GO:0004674 - protein serine/threonine kinase activity
GO:0004740 - pyruvate dehydrogenase (acetyl-transferring) kinase activity
GO:0005524 - ATP binding
GO:0005730 - nucleolus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1067963

PDK1
[Pyruvate dehydrogenase

5

11

High-throughput

0.922

High

1068139

PDK2
[Pyruvate dehydrogenase

3

11

High-throughput

0.871

High

1068153

PDK4
[Pyruvate dehydrogenase

3

11

High-throughput

0.871

High

489749

ODP2
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial

4

9

Small-scale

0.698

High

440525

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

4

9

Small-scale

0.696

High

431866

HS90A
Heat shock protein HSP 90-alpha

1

9

High-throughput

0.691

High

438184

HS90B
Heat shock protein HSP 90-beta

1

9

High-throughput

0.691

High

499759

CH60
60 kDa heat shock protein, mitochondrial

3

4

High-throughput

0.667

High

505832

ODPB
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial

3

6

High-throughput

0.667

High

1068183

ACAD9
Complex I assembly factor ACAD9, mitochondrial

3

6

High-throughput

0.667

High

1068154

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

3

1

Small-scale

0.640

High

452784

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

3

0

High-throughput

0.638

High

1068177

HDHD5
Haloacid dehalogenase-like hydrolase domain-containing 5

3

0

High-throughput

0.638

High

126247

ODPX
Pyruvate dehydrogenase protein X component, mitochondrial

2

9

High-throughput

0.628

High

258706

NDUS7
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial

2

3

High-throughput

0.628

High

573270

TCPA
T-complex protein 1 subunit alpha

2

11

High-throughput

0.628

High

669776

ODPAT
Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial

2

9

High-throughput

0.628

High

770843

TCPZ
T-complex protein 1 subunit zeta

2

11

High-throughput

0.628

High

821222

TCPE
T-complex protein 1 subunit epsilon

2

14

High-throughput

0.628

High

826673

TCPG
T-complex protein 1 subunit gamma

2

14

High-throughput

0.628

High

842877

TCPQ
T-complex protein 1 subunit theta

2

17

High-throughput

0.628

High

843206

TCPD
T-complex protein 1 subunit delta

2

11

High-throughput

0.628

High

943238

TCPB
T-complex protein 1 subunit beta

2

14

High-throughput

0.628

High

1068172

TCPH
T-complex protein 1 subunit eta

2

14

High-throughput

0.628

High

1020430

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

3

High-throughput

0.618

High

1050958

ICT1
Large ribosomal subunit protein mL62

2

1

High-throughput

0.611

High

1068162

HSC20
Iron-sulfur cluster co-chaperone protein HscB

2

1

High-throughput

0.611

High

338451

EGFR
Epidermal growth factor receptor

2

2

Small-scale

0.608

High

1068156

DNLZ
DNL-type zinc finger protein

2

0

High-throughput

0.602

High

227505

PRKN
E3 ubiquitin-protein ligase parkin

2

4

High-throughput

0.584

High

262820

CISY
Citrate synthase, mitochondrial

2

1

High-throughput

0.584

High

81553

B7Z207
Protein-serine/threonine kinase

1

11

High-throughput

0.575

High

786611

STA5A
Signal transducer and activator of transcription 5A

2

2

High-throughput

0.574

High

1021189

FOXD4
Forkhead box protein D4

2

3

High-throughput

0.574

High

1068161

SYT12
Synaptotagmin-12

2

1

High-throughput

0.574

High

815371

UCRI
Cytochrome b-c1 complex subunit Rieske, mitochondrial

1

3

High-throughput

0.536

High

874956

TERA
Transitional endoplasmic reticulum ATPase

1

1

High-throughput

0.536

High

1068173

NPS3B
Protein NipSnap homolog 3B

1

3

High-throughput

0.536

High

1068193

CHIP
E3 ubiquitin-protein ligase CHIP

1

2

High-throughput

0.536

High

369640

ESR1
Estrogen receptor

2

3

High-throughput

0.521

High

852936

HNRPM
Heterogeneous nuclear ribonucleoprotein M

1

1

High-throughput

0.515

High

561583

AT2A2
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2

1

0

High-throughput

0.513

High

1055121

HLTF
Helicase-like transcription factor

1

0

High-throughput

0.513

High

598943

FPR1
fMet-Leu-Phe receptor

1

5

High-throughput

0.489

High

684740

STIP1
Stress-induced-phosphoprotein 1

1

3

High-throughput

0.489

High

59187

VWA8
von Willebrand factor A domain-containing protein 8

1

1

High-throughput

0.479

High

63359

MET15
12S rRNA N4-methylcytidine

1

1

High-throughput

0.479

High

264910

MPPB
Mitochondrial-processing peptidase subunit beta

1

4

High-throughput

0.479

High

270037

RF1M
Peptide chain release factor 1, mitochondrial

1

2

High-throughput

0.479

High

327441

TRUB2
Pseudouridylate synthase TRUB2, mitochondrial

1

1

High-throughput

0.479

High

486529

COX8A
Cytochrome c oxidase subunit 8A, mitochondrial

1

1

High-throughput

0.479

High

737337

LONM
Lon protease homolog, mitochondrial

1

5

High-throughput

0.479

High

777569

MDHM
Malate dehydrogenase, mitochondrial

1

1

High-throughput

0.479

High

789800

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

1

High-throughput

0.479

High

799229

EFTS
Elongation factor Ts, mitochondrial

1

1

High-throughput

0.479

High

803118

IF2M
Translation initiation factor IF-2, mitochondrial

1

4

High-throughput

0.479

High

981255

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

2

High-throughput

0.479

High

990070

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

1

High-throughput

0.479

High

1014376

MPPA
Mitochondrial-processing peptidase subunit alpha

1

4

High-throughput

0.479

High

1017900

GRSF1
G-rich sequence factor 1

1

2

High-throughput

0.479

High

1045759

AUHM
Methylglutaconyl-CoA hydratase, mitochondrial

1

6

High-throughput

0.479

High

1068155

SYAM
Alanine--tRNA ligase, mitochondrial

1

2

High-throughput

0.479

High

1068157

MRM1
rRNA methyltransferase 1, mitochondrial

1

1

High-throughput

0.479

High

1068159

DHX30
ATP-dependent RNA helicase DHX30

1

1

High-throughput

0.479

High

1068160

FAKD5
FAST kinase domain-containing protein 5, mitochondrial

1

4

High-throughput

0.479

High

1068165

ESR2
Estrogen receptor beta

1

3

High-throughput

0.479

High

1068166

RRF2M
Ribosome-releasing factor 2, mitochondrial

1

2

High-throughput

0.479

High

1068167

FAKD4
FAST kinase domain-containing protein 4

1

4

High-throughput

0.479

High

1068169

RRFM
Ribosome-recycling factor, mitochondrial

1

1

High-throughput

0.479

High

1068171

EFGM
Elongation factor G, mitochondrial

1

3

High-throughput

0.479

High

1068174

TACO1
Translational activator of cytochrome c oxidase 1

1

1

High-throughput

0.479

High

1068175

TR61B
tRNA

1

2

High-throughput

0.479

High

1068176

HINT2
Adenosine 5'-monophosphoramidase HINT2

1

1

High-throughput

0.479

High

1068178

CC90B
Coiled-coil domain-containing protein 90B, mitochondrial

1

1

High-throughput

0.479

High

1068179

IF3M
Translation initiation factor IF-3, mitochondrial

1

1

High-throughput

0.479

High

1068180

MTG2
Mitochondrial ribosome-associated GTPase 2

1

1

High-throughput

0.479

High

1068182

MET17
Ribosome assembly protein METTL17, mitochondrial

1

1

High-throughput

0.479

High

1068185

EXD2
Exonuclease 3'-5' domain-containing protein 2

1

1

High-throughput

0.479

High

1068187

FAKD2
FAST kinase domain-containing protein 2, mitochondrial

1

4

High-throughput

0.479

High

1068189

MRES1
Mitochondrial transcription rescue factor 1

1

1

High-throughput

0.479

High

1068190

RF1ML
Peptide chain release factor 1-like, mitochondrial

1

2

High-throughput

0.479

High

1049

SIM26
Small integral membrane protein 26

1

0

High-throughput

0.464

High

262460

TULP3
Tubby-related protein 3

1

0

High-throughput

0.458

High

294850

RECQ4
ATP-dependent DNA helicase Q4

1

0

High-throughput

0.458

High

827391

EFTU
Elongation factor Tu, mitochondrial

1

0

High-throughput

0.458

High

958917

TFAM
Transcription factor A, mitochondrial

1

0

High-throughput

0.458

High

1068168

RUSD4
Pseudouridylate synthase RPUSD4, mitochondrial

1

0

High-throughput

0.458

High

1068186

RMND1
Required for meiotic nuclear division protein 1 homolog

1

0

High-throughput

0.458

High

1068188

WWOX
WW domain-containing oxidoreductase

1

0

High-throughput

0.458

High

1068194

RM11
Large ribosomal subunit protein uL11m

1

0

High-throughput

0.458

High

394741

A4
Amyloid-beta precursor protein

1

2

High-throughput

0.457

High

151000

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

3

High-throughput

0.437

High

552777

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.437

High

651260

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.437

High

720518

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.437

High

961125

HSF1
Heat shock factor protein 1

1

1

Small-scale

0.437

High

1041613

CUL3
Cullin-3

1

2

High-throughput

0.437

High

1042997

CUL4A
Cullin-4A

1

2

High-throughput

0.437

High

1068158

TRI67
Tripartite motif-containing protein 67

1

3

High-throughput

0.437

High

1068170

CIC
Protein capicua homolog

1

1

High-throughput

0.437

High

1068181

PKHA4
Pleckstrin homology domain-containing family A member 4

1

2

High-throughput

0.437

High

1068192

HECD1
E3 ubiquitin-protein ligase HECTD1

1

1

High-throughput

0.437

High

402036

JUN
Transcription factor Jun

1

2

High-throughput

0.407

High

327663

ECD
Protein ecdysoneless homolog

1

0

High-throughput

0.279

Low

535848

MIF
Macrophage migration inhibitory factor

1

0

High-throughput

0.279

Low

740917

FDFT
Squalene synthase

1

0

High-throughput

0.279

Low

809119

UTRN
Utrophin

1

0

High-throughput

0.279

Low

814080

IF1AX
Eukaryotic translation initiation factor 1A, X-chromosomal

1

0

High-throughput

0.279

Low

885862

YBEY
Endoribonuclease YbeY

1

0

High-throughput

0.279

Low

1066120

ACAP2
Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2

1

0

High-throughput

0.279

Low

1068163

UBR7
Putative E3 ubiquitin-protein ligase UBR7

1

0

High-throughput

0.279

Low

123602

PGRC1
Membrane-associated progesterone receptor component 1

1

0

Small-scale

0.249

Low

352105

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

0

High-throughput

0.249

Low

1068164

TNIP2
TNFAIP3-interacting protein 2

1

0

High-throughput

0.249

Low

1068184

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

0

High-throughput

0.249

Low

1068191

HERC5
E3 ISG15--protein ligase HERC5

1

0

Small-scale

0.249

Low


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Last updated: 15 Jul 2024