HitPredict

Interactor 1: WWP2 (O00308)
NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 2.3.2.26) (Atrophin-1-interacting protein 2) (AIP2) (HECT-type E3 ubiquitin transferase WWP2) (WW domain-containing protein 2)
Gene: WWP2

Interactor 2: UB2J2 (Q8N2K1)
Ubiquitin-conjugating enzyme E2 J2 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme J2) (Non-canonical ubiquitin-conjugating enzyme 2) (NCUBE-2)
Gene: UBE2J2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	22496338
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	HECT~UQ_con
Common GO terms	GO:0000151 - ubiquitin ligase complex GO:0005634 - nucleus GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 870 Hs			1 259
+	Hs
		1231676 ITCH_HUMAN (1-870): 0: 902: 54.26		UB2J2_HUMAN (1-259): 1.21e-110: 320: 100.00
+	Hs
		125808 WWP2_HUMAN (1-870): 0: 982: 100.00		UB2D4_HUMAN (12-156): 2.24e-67: 207: 24.16
+	Hs
		125262 WWP2_HUMAN (1-870): 0: 982: 100.00		UB2D1_HUMAN (12-156): 3.85e-66: 204: 24.16
+	Hs
		125335 WWP2_HUMAN (1-870): 0: 982: 100.00		UB2D2_HUMAN (12-156): 3.65e-66: 204: 22.82
+	Hs
		125300 WWP2_HUMAN (1-870): 0: 982: 100.00		UB2D3_HUMAN (12-156): 2.8e-65: 201: 22.15
+	Hs
		125629 WWP2_HUMAN (1-870): 0: 982: 100.00		UB2E3_HUMAN (1-157): 8.61e-62: 194: 25.47
+	Hs
		125655 WWP2_HUMAN (1-870): 0: 982: 100.00		UB2E2_HUMAN (1-157): 3.56e-61: 193: 25.47
+	Hs
		125263 WWP2_HUMAN (1-870): 0: 982: 100.00		UB2E1_HUMAN (1-157): 7.51e-61: 192: 24.85
+	Hs
		1294888 ITCH_HUMAN (1-870): 0: 902: 54.26		UB2D4_HUMAN (12-156): 2.24e-67: 207: 24.16
+	Hs
		849411 ITCH_HUMAN (1-870): 0: 902: 54.26		UB2D1_HUMAN (12-156): 3.85e-66: 204: 24.16
+	Hs
		919827 ITCH_HUMAN (1-870): 0: 902: 54.26		UB2D2_HUMAN (12-156): 3.65e-66: 204: 22.82
+	Hs
		895882 ITCH_HUMAN (1-870): 0: 902: 54.26		UB2D3_HUMAN (12-156): 2.8e-65: 201: 22.15
+	Hs
		1282329 ITCH_HUMAN (1-870): 0: 902: 54.26		UB2E3_HUMAN (1-157): 8.61e-62: 194: 25.47
+	Hs
		1294835 ITCH_HUMAN (1-870): 0: 902: 54.26		UB2E2_HUMAN (1-157): 3.56e-61: 193: 25.47
+	Hs
		851871 ITCH_HUMAN (1-870): 0: 902: 54.26		UB2E1_HUMAN (1-157): 7.51e-61: 192: 24.85
+	Hs
		849444 WWP1_HUMAN (1-870): 0: 888: 58.38		UB2D1_HUMAN (12-156): 3.85e-66: 204: 24.16
+	Hs
		919860 WWP1_HUMAN (1-870): 0: 888: 58.38		UB2D2_HUMAN (12-156): 3.65e-66: 204: 22.82
+	Hs
		895910 WWP1_HUMAN (1-870): 0: 888: 58.38		UB2D3_HUMAN (12-156): 2.8e-65: 201: 22.15
+	Dm
		854579 SUDX_DROME (14-870): 0: 852: 52.14		UBCD2_DROME (2-157): 3.01e-58: 186: 25.00
+	Xl
		1151480 Q6GMD5_XENLA (2-867): 0: 792: 30.81		Q6WKX0_XENLA (1-157): 3.03e-62: 196: 25.47