Protein: LASP1
LIM and SH3 domain protein 1 (LASP-1) (Metastatic lymph node gene 50 protein) (MLN 50)

Gene: LASP1
Organism: Homo sapiens
Interactions: 248
UniProt ID: Q14847

Gene Ontology (top 5):
GO:0005737 - cytoplasm
GO:0005925 - focal adhesion
GO:0006811 - monoatomic ion transport
GO:0015075 - monoatomic ion transmembrane transporter activity
GO:0030864 - cortical actin cytoskeleton

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1060079

UBQL2
Ubiquilin-2

3

9

High-throughput

0.843

High

1059978

ZYX
Zyxin

3

20

Small-scale

0.836

High

1060075

ZO2
Tight junction protein ZO-2

2

19

Small-scale

0.802

High

146497

BHE40
Class E basic helix-loop-helix protein 40

2

1

High-throughput

0.783

High

433354

YES
Tyrosine-protein kinase Yes

2

20

High-throughput

0.783

High

903717

LMO4
LIM domain transcription factor LMO4

2

8

High-throughput

0.783

High

1059990

ARHGG
Rho guanine nucleotide exchange factor 16

2

9

High-throughput

0.783

High

1059997

DOK6
Docking protein 6

2

2

High-throughput

0.783

High

802603

CRK
Adapter molecule crk

2

20

High-throughput

0.767

High

346806

MYC
Myc proto-oncogene protein

2

12

High-throughput

0.754

High

302678

ARHGF
Rho guanine nucleotide exchange factor 15

1

9

High-throughput

0.740

High

1044592

FHL3
Four and a half LIM domains protein 3

1

13

High-throughput

0.698

High

868494

ATX1
Ataxin-1

4

8

High-throughput

0.698

High

1033469

ILK
Integrin-linked protein kinase

1

4

High-throughput

0.691

High

1059976

PCH2
Pachytene checkpoint protein 2 homolog

6

2

High-throughput

0.677

High

1060047

MDFI
MyoD family inhibitor

4

0

High-throughput

0.673

High

1060007

ZDH17
Palmitoyltransferase ZDHHC17

1

12

High-throughput

0.672

High

1060029

RBPMS
RNA-binding protein with multiple splicing

3

1

High-throughput

0.671

High

1060068

KTU
Protein kintoun

3

1

High-throughput

0.667

High

1060039

EHMT2
Histone-lysine N-methyltransferase EHMT2

1

8

Small-scale

0.648

High

1060046

UHRF1
E3 ubiquitin-protein ligase UHRF1

1

4

Small-scale

0.648

High

1059975

DAZP2
DAZ-associated protein 2

3

0

High-throughput

0.643

High

1060037

ZN764
Zinc finger protein 764

2

4

High-throughput

0.628

High

1060065

SH22A
SH2 domain-containing protein 2A

2

20

High-throughput

0.628

High

1060031

ZBTB9
Zinc finger and BTB domain-containing protein 9

2

8

High-throughput

0.628

High

551148

ITF2
Transcription factor 4

1

0

High-throughput

0.619

High

227474

PRKN
E3 ubiquitin-protein ligase parkin

1

10

High-throughput

0.618

High

840475

VASP
Vasodilator-stimulated phosphoprotein

1

16

High-throughput

0.618

High

1060064

PKHA4
Pleckstrin homology domain-containing family A member 4

1

20

High-throughput

0.618

High

1060077

TES
Testin

1

11

High-throughput

0.618

High

1060049

RHXF2
Rhox homeobox family member 2

3

3

High-throughput

0.616

High

1060011

THAP8
THAP domain-containing protein 8

2

1

High-throughput

0.611

High

118313

HAX1
HCLS1-associated protein X-1

3

2

High-throughput

0.609

High

1060042

RDH12
Retinol dehydrogenase 12

3

2

High-throughput

0.609

High

160000

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

2

2

High-throughput

0.606

High

314048

BAG4
BAG family molecular chaperone regulator 4

2

4

High-throughput

0.606

High

409345

CRBA1
Beta-crystallin A3 [Cleaved into: Beta-crystallin A3, isoform A1, Delta4 form; Beta-crystallin A3, isoform A1, Delta7 form; Beta-crystallin A3, isoform A1, Delta8 form]

2

1

High-throughput

0.606

High

941903

PITX1
Pituitary homeobox 1

2

3

High-throughput

0.606

High

1023461

MKRN3
Probable E3 ubiquitin-protein ligase makorin-3

2

1

High-throughput

0.606

High

1048534

VEZF1
Vascular endothelial zinc finger 1

2

1

High-throughput

0.606

High

1059980

QRIC1
Transcriptional regulator QRICH1

2

15

High-throughput

0.606

High

1059991

TENS2
Tensin-2

2

4

High-throughput

0.606

High

1059998

RBPS2
RNA-binding protein with multiple splicing 2

2

1

High-throughput

0.606

High

1060004

DTX2
Probable E3 ubiquitin-protein ligase DTX2

2

15

High-throughput

0.606

High

1060008

CHERP
Calcium homeostasis endoplasmic reticulum protein

2

6

High-throughput

0.606

High

1060024

TFG
Protein TFG

2

20

High-throughput

0.606

High

1060053

YTHD1
YTH domain-containing family protein 1

2

2

High-throughput

0.606

High

1060066

DMRT3
Doublesex- and mab-3-related transcription factor 3

2

1

High-throughput

0.606

High

1060070

RFOX1
RNA binding protein fox-1 homolog 1

2

8

High-throughput

0.606

High

1060073

WWOX
WW domain-containing oxidoreductase

2

2

High-throughput

0.606

High

1060080

CTNA3
Catenin alpha-3

2

9

High-throughput

0.606

High

1060082

KCC2A
Calcium/calmodulin-dependent protein kinase type II subunit alpha

2

7

High-throughput

0.606

High

443521

VIME
Vimentin

2

17

High-throughput

0.601

High

231523

KIF1B
Kinesin-like protein KIF1B

1

10

High-throughput

0.594

High

609289

FGFR3
Fibroblast growth factor receptor 3

1

20

High-throughput

0.594

High

776688

STAT3
Signal transducer and activator of transcription 3

2

1

High-throughput

0.594

High

270985

GCM2
Chorion-specific transcription factor GCMb

2

0

High-throughput

0.580

High

658365

DPOD1
DNA polymerase delta catalytic subunit

2

0

High-throughput

0.580

High

1059986

ACTMP
Actin maturation protease

2

0

High-throughput

0.580

High

1059989

INT11
Integrator complex subunit 11

2

0

High-throughput

0.580

High

1060002

SAXO4
Stabilizer of axonemal microtubules 4

2

0

High-throughput

0.580

High

1060033

FBX17
F-box only protein 17

2

0

High-throughput

0.580

High

1060038

ZC3HA
Zinc finger CCCH domain-containing protein 10

2

0

High-throughput

0.580

High

1060048

SPAG8
Sperm-associated antigen 8

2

0

High-throughput

0.580

High

1060060

RNF38
E3 ubiquitin-protein ligase RNF38

2

0

High-throughput

0.580

High

840694

DYN2
Dynamin-2

1

20

Small-scale

0.575

High

983377

DYN1
Dynamin-1

1

20

Small-scale

0.575

High

1060028

LPP
Lipoma-preferred partner

1

18

Small-scale

0.575

High

1060027

CSN5
COP9 signalosome complex subunit 5

1

9

Small-scale

0.573

High

536835

TRI27
Zinc finger protein RFP

1

7

High-throughput

0.573

High

844067

FXR2
RNA-binding protein FXR2

1

6

High-throughput

0.573

High

994876

GOGA2
Golgin subfamily A member 2

1

10

High-throughput

0.573

High

1060035

ZC21A
Zinc finger C2HC domain-containing protein 1A

1

2

High-throughput

0.573

High

625764

CXCR2
C-X-C chemokine receptor type 2

2

5

Small-scale

0.567

High

863863

CRBA2
Beta-crystallin A2

2

1

High-throughput

0.561

High

1060023

ANS1A
Ankyrin repeat and SAM domain-containing protein 1A

1

18

High-throughput

0.555

High

49952

F168B
Myelin-associated neurite-outgrowth inhibitor

2

1

High-throughput

0.553

High

60577

VP37C
Vacuolar protein sorting-associated protein 37C

2

20

High-throughput

0.553

High

211857

TLX3
T-cell leukemia homeobox protein 3

2

5

High-throughput

0.553

High

270785

FOXH1
Forkhead box protein H1

2

3

High-throughput

0.553

High

330078

DRC4
Dynein regulatory complex subunit 4

2

1

High-throughput

0.553

High

474600

PRR35
Proline-rich protein 35

2

1

High-throughput

0.553

High

656404

PIT1
Pituitary-specific positive transcription factor 1

2

1

High-throughput

0.553

High

686438

OTX1
Homeobox protein OTX1

2

5

High-throughput

0.553

High

829852

HXA1
Homeobox protein Hox-A1

2

5

High-throughput

0.553

High

855061

HNRPF
Heterogeneous nuclear ribonucleoprotein F

2

5

High-throughput

0.553

High

889477

KR108
Keratin-associated protein 10-8

2

3

High-throughput

0.553

High

903811

NTF2
Nuclear transport factor 2

2

2

High-throughput

0.553

High

977676

EVX2
Homeobox even-skipped homolog protein 2

2

6

High-throughput

0.553

High

978172

ARI5A
AT-rich interactive domain-containing protein 5A

2

2

High-throughput

0.553

High

997371

VAC14
Protein VAC14 homolog

2

1

High-throughput

0.553

High

1059988

GT253
Inactive glycosyltransferase 25 family member 3

2

2

High-throughput

0.553

High

1060013

CTSR1
Cation channel sperm-associated protein 1

2

4

High-throughput

0.553

High

1060018

OXER1
Oxoeicosanoid receptor 1

2

3

High-throughput

0.553

High

1060021

TEKT4
Tektin-4

2

2

High-throughput

0.553

High

1060022

F168A
Protein FAM168A

2

1

High-throughput

0.553

High

1060040

TEKT5
Tektin-5

2

2

High-throughput

0.553

High

1060044

LENG8
Leukocyte receptor cluster member 8

2

11

High-throughput

0.553

High

1060052

TEKT3
Tektin-3

2

2

High-throughput

0.553

High

1060055

KRA33
Keratin-associated protein 3-3

2

1

High-throughput

0.553

High

1060056

KRA32
Keratin-associated protein 3-2

2

1

High-throughput

0.553

High

1060061

CSTFT
Cleavage stimulation factor subunit 2 tau variant

2

2

High-throughput

0.553

High

607971

FGFR4
Fibroblast growth factor receptor 4

1

20

High-throughput

0.553

High

637882

PSA3
Proteasome subunit alpha type-3

1

0

High-throughput

0.549

High

869644

TERF1
Telomeric repeat-binding factor 1

1

3

High-throughput

0.541

High

497030

TAU
Microtubule-associated protein tau

1

20

High-throughput

0.536

High

574338

RL35A
Large ribosomal subunit protein eL33

1

4

High-throughput

0.536

High

1060015

RIN3
Ras and Rab interactor 3

1

20

High-throughput

0.536

High

208139

SPY2
Protein sprouty homolog 2

1

4

High-throughput

0.523

High

981581

REL
Proto-oncogene c-Rel

1

2

High-throughput

0.523

High

1060050

LZTS2
Leucine zipper putative tumor suppressor 2

1

17

High-throughput

0.523

High

1060054

KRA42
Keratin-associated protein 4-2

1

3

High-throughput

0.523

High

1060069

THAP1
THAP domain-containing protein 1

1

1

High-throughput

0.523

High

1060078

SEPT3
Neuronal-specific septin-3

1

2

High-throughput

0.523

High

170072

PLS1
Phospholipid scramblase 1

1

0

High-throughput

0.518

High

349323

RASH
GTPase HRas

1

11

High-throughput

0.515

High

358760

CRYAA
Alpha-crystallin A chain

1

6

High-throughput

0.515

High

388448

HSPB1
Heat shock protein beta-1

1

6

High-throughput

0.515

High

413913

GELS
Gelsolin

1

5

High-throughput

0.515

High

422179

NFL
Neurofilament light polypeptide

1

17

High-throughput

0.515

High

499749

CH60
60 kDa heat shock protein, mitochondrial

1

1

High-throughput

0.515

High

535397

GFAP
Glial fibrillary acidic protein

1

17

High-throughput

0.515

High

657919

CLAT
Choline O-acetyltransferase

1

1

High-throughput

0.515

High

1026166

PAK1
Serine/threonine-protein kinase PAK 1

1

19

High-throughput

0.515

High

1060010

BOLL
Protein boule-like

1

2

High-throughput

0.515

High

1060026

KLK6
Kallikrein-6

1

4

High-throughput

0.515

High

1060032

OPTN
Optineurin

1

17

High-throughput

0.515

High

1059994

PKHA7
Pleckstrin homology domain-containing family A member 7

1

20

High-throughput

0.514

High

641218

DNMT1
DNA

1

1

Small-scale

0.512

High

152289

ADA10
Disintegrin and metalloproteinase domain-containing protein 10

1

20

Small-scale

0.501

High

994082

PP2BA
Protein phosphatase 3 catalytic subunit alpha

1

3

Small-scale

0.501

High

1060030

ACD
Adrenocortical dysplasia protein homolog

1

2

High-throughput

0.494

High

1060051

TINF2
TERF1-interacting nuclear factor 2

1

1

High-throughput

0.494

High

1060067

POTE1
Protection of telomeres protein 1

1

2

High-throughput

0.494

High

363152

FINC
Fibronectin

1

5

High-throughput

0.489

High

117700

MYO1C
Unconventional myosin-Ic

1

8

Small-scale

0.479

High

135445

PPP6
Serine/threonine-protein phosphatase 6 catalytic subunit

1

1

High-throughput

0.479

High

233456

NUPR1
Nuclear protein 1

1

3

High-throughput

0.479

High

278086

PIAS1
E3 SUMO-protein ligase PIAS1

1

1

High-throughput

0.479

High

322642

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

7

High-throughput

0.479

High

326643

SNAI1
Zinc finger protein SNAI1

1

1

Small-scale

0.479

High

374245

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

13

High-throughput

0.479

High

430183

PROF1
Profilin-1

1

2

High-throughput

0.479

High

504095

HSP7C
Heat shock cognate 71 kDa protein

1

7

High-throughput

0.479

High

521936

CADH1
Cadherin-1

1

8

High-throughput

0.479

High

529127

CFTR
Cystic fibrosis transmembrane conductance regulator

1

5

High-throughput

0.479

High

547059

EZRI
Ezrin

1

11

Small-scale

0.479

High

569735

CEBPB
CCAAT/enhancer-binding protein beta

1

4

High-throughput

0.479

High

590929

BTF3
Transcription factor BTF3

1

1

High-throughput

0.479

High

668691

PML
Protein PML

1

4

High-throughput

0.479

High

684040

1433S
14-3-3 protein sigma

1

20

Small-scale

0.479

High

719713

RADI
Radixin

1

12

High-throughput

0.479

High

742297

SYUA
Alpha-synuclein

1

3

High-throughput

0.479

High

779423

CCNF
Cyclin-F

1

4

High-throughput

0.479

High

781893

PERI
Peripherin

1

17

High-throughput

0.479

High

786351

STAT1
Signal transducer and activator of transcription 1-alpha/beta

1

1

High-throughput

0.479

High

830625

CXCR3
C-X-C chemokine receptor type 3

1

5

Small-scale

0.479

High

874937

TERA
Transitional endoplasmic reticulum ATPase

1

1

High-throughput

0.479

High

887851

CD81
CD81 antigen

1

2

High-throughput

0.479

High

891770

ACTB
Actin, cytoplasmic 1

1

20

High-throughput

0.479

High

895623

CXCR4
C-X-C chemokine receptor type 4

1

5

Small-scale

0.479

High

896741

ARP3
Actin-related protein 3

1

20

Small-scale

0.479

High

934771

H31
Histone H3.1

1

1

Small-scale

0.479

High

960797

CLH1
Clathrin heavy chain 1

1

1

Small-scale

0.479

High

998718

EP300
Histone acetyltransferase p300

1

19

High-throughput

0.479

High

1016178

FOXO1
Forkhead box protein O1

1

5

High-throughput

0.479

High

1024333

UBP4
Ubiquitin carboxyl-terminal hydrolase 4

1

5

High-throughput

0.479

High

1041593

CUL3
Cullin-3

1

5

High-throughput

0.479

High

1045413

SPTN1
Spectrin alpha chain, non-erythrocytic 1

1

9

Small-scale

0.479

High

1051278

DCTN1
Dynactin subunit 1

1

9

High-throughput

0.479

High

1059992

DCA15
DDB1- and CUL4-associated factor 15

1

3

High-throughput

0.479

High

1059999

TRI67
Tripartite motif-containing protein 67

1

19

High-throughput

0.479

High

1060014

TNIP2
TNFAIP3-interacting protein 2

1

2

High-throughput

0.479

High

1060017

BICD2
Protein bicaudal D homolog 2

1

19

High-throughput

0.479

High

1060025

REQU
Zinc finger protein ubi-d4

1

7

High-throughput

0.479

High

1060062

CCDC8
Coiled-coil domain-containing protein 8

1

2

High-throughput

0.479

High

1060074

HDAC6
Histone deacetylase 6

1

8

High-throughput

0.479

High

1060076

ZRAN1
Ubiquitin thioesterase ZRANB1

1

10

High-throughput

0.479

High

1060081

G3BP2
Ras GTPase-activating protein-binding protein 2

1

3

Small-scale

0.479

High

1060085

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

1

4

Small-scale

0.479

High

281628

WFS1
Wolframin

1

1

High-throughput

0.470

High

557459

PECA1
Platelet endothelial cell adhesion molecule

1

5

High-throughput

0.470

High

953013

PR20D
Proline-rich protein 20D

1

1

High-throughput

0.470

High

1059973

NMDE3
Glutamate receptor ionotropic, NMDA 2C

1

6

High-throughput

0.470

High

1059985

Q49AR9
ANKS1A protein

1

11

High-throughput

0.470

High

1060006

Q86V38
Atrophin 1

1

19

High-throughput

0.470

High

1060084

RNF11
RING finger protein 11

1

1

High-throughput

0.470

High

408804

K1C18
Keratin, type I cytoskeletal 18

1

0

Small-scale

0.458

High

729089

K22E
Keratin, type II cytoskeletal 2 epidermal

1

0

Small-scale

0.458

High

1060057

API5
Apoptosis inhibitor 5

1

0

Small-scale

0.458

High

378051

PRIO
Major prion protein

1

2

High-throughput

0.445

High

953077

PR20A
Proline-rich protein 20A

1

1

High-throughput

0.439

High

100769

APRIO
Alternative prion protein

1

4

High-throughput

0.437

High

244448

BRD4
Bromodomain-containing protein 4

1

3

High-throughput

0.437

High

552743

RFA2
Replication protein A 32 kDa subunit

1

9

High-throughput

0.437

High

582298

NUCL
Nucleolin

1

2

Small-scale

0.437

High

625738

CXCR1
C-X-C chemokine receptor type 1

1

5

Small-scale

0.437

High

641777

U2AF2
Splicing factor U2AF 65 kDa subunit

1

3

High-throughput

0.437

High

720484

RFA3
Replication protein A 14 kDa subunit

1

5

High-throughput

0.437

High

841729

CDK9
Cyclin-dependent kinase 9

1

8

High-throughput

0.437

High

1029434

TIF1B
Transcription intermediary factor 1-beta

1

9

High-throughput

0.437

High

1055281

PDIA5
Protein disulfide-isomerase A5

1

2

Small-scale

0.437

High

1059974

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

6

High-throughput

0.437

High

1059977

EZH2
Histone-lysine N-methyltransferase EZH2

1

6

High-throughput

0.437

High

1059979

CCDC6
Coiled-coil domain-containing protein 6

1

17

High-throughput

0.437

High

1059987

CE170
Centrosomal protein of 170 kDa

1

10

High-throughput

0.437

High

1059993

A16L1
Autophagy-related protein 16-1

1

12

High-throughput

0.437

High

1060005

NAA40
N-alpha-acetyltransferase 40

1

5

High-throughput

0.437

High

1060019

FBF1
Fas-binding factor 1

1

15

High-throughput

0.437

High

1060034

BICD1
Protein bicaudal D homolog 1

1

20

High-throughput

0.437

High

1060041

SCLT1
Sodium channel and clathrin linker 1

1

15

High-throughput

0.437

High

1060072

CDK12
Cyclin-dependent kinase 12

1

8

Small-scale

0.437

High

1060087

NCOR2
Nuclear receptor corepressor 2

1

18

Small-scale

0.437

High

717834

BMI1
Polycomb complex protein BMI-1

1

4

High-throughput

0.407

High

1060058

ZDHC5
Palmitoyltransferase ZDHHC5

1

5

High-throughput

0.407

High

831333

CEBPA
CCAAT/enhancer-binding protein alpha

1

4

High-throughput

0.373

High

234073

O10H3
Olfactory receptor 10H3

3

0

High-throughput

0.347

High

886929

T2R41
Taste receptor type 2 member 41

3

0

High-throughput

0.347

High

1060012

MFI
Protein MFI

3

0

High-throughput

0.347

High

1060045

UIF
UAP56-interacting factor

3

0

High-throughput

0.347

High

1060063

S2532
Solute carrier family 25 member 32

3

0

High-throughput

0.347

High

1060020

SNR27
U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein

2

0

High-throughput

0.328

High

617753

NFYA
Nuclear transcription factor Y subunit alpha

2

0

High-throughput

0.318

High

1060036

S2544
Solute carrier family 25 member 44

2

0

High-throughput

0.318

High

67077

CRTP1
Cysteine-rich tail protein 1

2

0

High-throughput

0.316

High

67960

VGLL3
Transcription cofactor vestigial-like protein 3

2

0

High-throughput

0.316

High

888640

KR124
Keratin-associated protein 12-4

2

0

High-throughput

0.316

High

1059981

KRA62
Keratin-associated protein 6-2

2

0

High-throughput

0.316

High

1059982

KR196
Keratin-associated protein 19-6

2

0

High-throughput

0.316

High

1059983

KR194
Keratin-associated protein 19-4

2

0

High-throughput

0.316

High

1059995

UFSP1
Inactive Ufm1-specific protease 1

2

0

High-throughput

0.316

High

1059996

KR261
Keratin-associated protein 26-1

2

0

High-throughput

0.316

High

1060000

MED25
Mediator of RNA polymerase II transcription subunit 25

2

0

High-throughput

0.316

High

1060001

KR193
Keratin-associated protein 19-3

2

0

High-throughput

0.316

High

1060003

NOXA1
NADPH oxidase activator 1

2

0

High-throughput

0.316

High

1060016

BAHD1
Bromo adjacent homology domain-containing 1 protein

2

0

High-throughput

0.316

High

1060043

GUCD1
Protein GUCD1

2

0

High-throughput

0.316

High

1060071

CN119
Uncharacterized protein C14orf119

2

0

High-throughput

0.316

High

1060009

FA24B
Protein FAM24B

1

0

High-throughput

0.279

Low

660495

GRN
Progranulin

1

0

High-throughput

0.268

Low

1060086

BACE2
Beta-secretase 2

1

0

High-throughput

0.268

Low

1059984

MGT5B
Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B

1

0

High-throughput

0.251

Low

340456

PGK1
Phosphoglycerate kinase 1

1

0

Small-scale

0.249

Low

393204

AT1A1
Sodium/potassium-transporting ATPase subunit alpha-1

1

0

High-throughput

0.249

Low

654341

CALX
Calnexin

1

0

High-throughput

0.249

Low

1060059

NAT10
RNA cytidine acetyltransferase

1

0

Small-scale

0.249

Low

1060083

AP3M1
AP-3 complex subunit mu-1

1

0

Small-scale

0.249

Low

1043

SIM26
Small integral membrane protein 26

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024