HitPredict

Interactor 1: WWP2 (O00308)
NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 2.3.2.26) (Atrophin-1-interacting protein 2) (AIP2) (HECT-type E3 ubiquitin transferase WWP2) (WW domain-containing protein 2)
Gene: WWP2

Interactor 2: USP9X (Q93008)
Ubiquitin carboxyl-terminal hydrolase 9X (EC 3.4.19.12) (Deubiquitinating enzyme FAF-X) (Fat facets in mammals) (hFAM) (Fat facets protein-related, X-linked) (Ubiquitin thioesterase FAF-X) (Ubiquitin-specific protease 9, X chromosome) (Ubiquitin-specific-processing protease FAF-X)
Gene: USP9X

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.71	0.60	0.656

Property	Details
Experiments	25071155, 31048545, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0016020 - membrane and 1 others more... GO:0016567 - protein ubiquitination
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 870 Hs			1 2554
+	Hs
		1273700 ITCH_HUMAN (1-870): 0: 902: 54.26		USP9X_HUMAN (1-2554): 0: 3676: 100.00
+	Hs
		1273724 WWP1_HUMAN (1-870): 0: 888: 58.38		USP9X_HUMAN (1-2554): 0: 3676: 100.00
+	Hs
		1192153 HUWE1_HUMAN (241-869): 7.77e-179: 575: 30.03		USP9X_HUMAN (1-2554): 0: 3676: 100.00
+	Hs
		1273741 SMUF1_HUMAN (1-385): 1.35e-45: 177: 17.77		USP9X_HUMAN (1-2554): 0: 3676: 100.00
+	Hs
		1273751 HECW2_HUMAN (154-531): 5.96e-16: 84.8: 17.23		USP9X_HUMAN (1-2554): 0: 3676: 100.00
+	Hs
		125794 WWP2_HUMAN (1-870): 0: 982: 100.00		UBP24_HUMAN (36-2478): 0: 2211: 29.78
+	Hs
		125625 WWP2_HUMAN (1-870): 0: 982: 100.00		UBP7_HUMAN (1469-2119): 8.05e-96: 339: 18.82
+	Hs
		64219 ITCH_HUMAN (1-870): 0: 902: 54.26		UBP27_HUMAN (1524-1949): 2.29e-96: 321: 17.61
+	Hs
		259303 ITCH_HUMAN (1-870): 0: 902: 54.26		UBP12_HUMAN (1519-1957): 8.45e-94: 311: 21.51
+	Hs
		1273807 NED4L_HUMAN (5-867): 0: 785: 32.17		UBP7_HUMAN (1469-2119): 8.05e-96: 339: 18.82
+	Mm
		1149452 HUWE1_MOUSE (241-869): 2.82e-179: 576: 29.56		UBP7_MOUSE (1469-2119): 1.12e-95: 339: 18.82
+	Hs
		1192154 HUWE1_HUMAN (241-869): 7.77e-179: 575: 30.03		UBP7_HUMAN (1469-2119): 8.05e-96: 339: 18.82
+	Hs
		1176343 HECW1_HUMAN (187-523): 3.02e-13: 76.4: 19.58		UBP7_HUMAN (1469-2119): 8.05e-96: 339: 18.82