HitPredict

Interactor 1: DI3L1 (Q8TF46)
DIS3-like exonuclease 1 (EC 3.1.13.1)
Gene: DIS3L

Interactor 2: EXOS1 (Q9Y3B2)
Exosome complex component CSL4 (Exosome component 1)
Gene: EXOSC1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.87	0.60	0.723

Property	Details
Experiments	26496610, 28514442, 24981860, 33961781, 20531386
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000177 - cytoplasmic exosome (RNase complex) GO:0003723 - RNA binding GO:0005829 - cytosol GO:0006396 - RNA processing GO:0006401 - RNA catabolic process
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 1054 Hs			1 195
+	Hs
		1046312 DI3L1_HUMAN (1-1054): 0: 1322: 100.00		EXOS2_HUMAN (7-174): 3.42e-57: 183: 19.19
+	Hs
		1377305 RRP44_HUMAN (5-991): 0: 1027: 33.76		EXOS1_HUMAN (1-195): 1.33e-103: 297: 100.00
+	Hs
		1046361 RRP44_HUMAN (5-991): 0: 1027: 33.76		EXOS2_HUMAN (7-174): 3.42e-57: 183: 19.19
+	Dm
		1362697 Q9VC93_DROME (7-988): 0: 943: 31.52		Q9VKJ4_DROME (7-191): 2.55e-71: 216: 47.90
+	Dm
		1362702 Q9VC93_DROME (7-988): 0: 943: 31.52		Q9W1M9_DROME (6-174): 1.43e-55: 179: 21.39
+	Sp
		740322 DIS3_SCHPO (5-972): 0: 941: 32.54		RRP4_SCHPO (7-152): 1.21e-55: 180: 21.92
+	Sp
		223735 DIS3_SCHPO (5-972): 0: 941: 32.54		CSL4_SCHPO (7-187): 3.75e-55: 174: 42.86
+	Sc
		755005 RRP44_YEAST (2-971): 0: 893: 31.47		RRP4_YEAST (6-152): 8.24e-53: 174: 21.77
+	Sc
		865428 RRP44_YEAST (2-971): 0: 893: 31.47		CSL4_YEAST (64-187): 7.62e-38: 133: 36.25
+	Pf
		1212345 Q8IDB6_PLAF7 (6-301): 2.09e-67: 248: 16.57		Q9U0I4_PLAF7 (6-174): 2.51e-44: 151: 14.69