HitPredict

Interactor 1: MASP2 (O00187)
Mannan-binding lectin serine protease 2 (EC 3.4.21.104) (MBL-associated serine protease 2) (Mannose-binding protein-associated serine protease 2) (MASP-2) [Cleaved into: Mannan-binding lectin serine protease 2 A chain; Mannan-binding lectin serine protease 2 B chain]
Gene: MASP2

Interactor 2: CO4B (P0C0L5)
Complement C4-B (Basic complement C4) (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 3) [Cleaved into: Complement C4 beta chain; Complement C4-B alpha chain; C4a anaphylatoxin; C4b-B; C4d-B; Complement C4 gamma chain]
Gene: C4B

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.70 1.00 0.840

The method score is based on:

Property Details
Experiments 11527969, 22071314, 23785123
Identification Methods protease assay, enzyme linked immunosorbent assay, solid phase assay
Interaction Type cleavage reaction, direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains A2M~Sushi, A2M_BRD~Sushi, MG2~Sushi, MG4~Sushi, NTR~Sushi, Sushi~TED_complement, A2M_recep~Trypsin, MG2~Trypsin
Common GO terms GO:0005576 - extracellular region
GO:0005615 - extracellular space
GO:0006958 - complement activation, classical pathway
GO:0070062 - extracellular exosome
Homologous interactions 8

Homologous interactions

Color coding for hit scores

1 686
Hs

1 1744
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Last updated: 15 Jul 2024