HitPredict

Interactor 1: SOCS7 (Q8VHQ2)
Suppressor of cytokine signaling 7 (SOCS-7)
Gene: SOCS7

Interactor 2: CUL5 (Q9D5V5)
Cullin-5 (CUL-5)
Gene: CUL5

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	19385048
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Cullin~SOCS_box
Common GO terms	GO:0005634 - nucleus GO:0016567 - protein ubiquitination GO:0021799 - cerebral cortex radially oriented cell migration GO:0021942 - radial glia guided migration of Purkinje cell
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 579 Mm			1 780
+	Hs
		146692 SOCS7_HUMAN (1-579): 0: 651: 96.56		CUL5_HUMAN (1-780): 0: 781: 98.46
+	Hs
		256856 SOCS5_HUMAN (307-561): 4.34e-74: 247: 22.76		CUL5_HUMAN (1-780): 0: 781: 98.46
+	Mm
		222648 SOCS5_MOUSE (307-561): 5.6e-73: 244: 22.39		CUL5_MOUSE (1-780): 0: 783: 100.00
+	Hs
		1263831 SOCS4_HUMAN (356-566): 2.25e-68: 229: 27.01		CUL5_HUMAN (1-780): 0: 781: 98.46
+	Mm
		1265273 SOCS4_MOUSE (356-566): 2.95e-67: 226: 27.49		CUL5_MOUSE (1-780): 0: 783: 100.00
+	Hs
		147544 SOCS6_HUMAN (351-551): 7.23e-57: 201: 46.77		CUL5_HUMAN (1-780): 0: 781: 98.46
+	Hs
		146642 SOCS2_HUMAN (363-552): 2.75e-60: 200: 30.57		CUL5_HUMAN (1-780): 0: 781: 98.46
+	Mm
		193366 SOCS2_MOUSE (363-552): 3.71e-59: 197: 29.02		CUL5_MOUSE (1-780): 0: 783: 100.00
+	Mm
		1322060 SOCS6_MOUSE (351-551): 7.58e-54: 193: 46.77		CUL5_MOUSE (1-780): 0: 783: 100.00
+	Mm
		1143676 CISH_MOUSE (320-552): 1.54e-56: 192: 25.77		CUL5_MOUSE (1-780): 0: 783: 100.00
+	Hs
		1274062 CISH_HUMAN (320-552): 5.29e-56: 191: 24.90		CUL5_HUMAN (1-780): 0: 781: 98.46
+	Mm
		193357 SOCS1_MOUSE (353-552): 3.56e-48: 168: 22.50		CUL5_MOUSE (1-780): 0: 783: 100.00
+	Hs
		181885 SOCS1_HUMAN (370-552): 1.86e-48: 169: 23.50		CUL5_HUMAN (1-780): 0: 781: 98.46
+	Hs
		146625 SOCS2_HUMAN (363-552): 2.75e-60: 200: 30.57		CUL4A_HUMAN (16-780): 0: 733: 24.61
+	Mm
		193394 SOCS3_MOUSE (360-549): 8.62e-39: 143: 23.29		CUL5_MOUSE (1-780): 0: 783: 100.00
+	Hs
		655358 P85A_HUMAN (388-573): 5.64e-45: 171: 21.93		CUL3_HUMAN (8-780): 0: 743: 22.71
+	Hs
		1041644 SHB_HUMAN (293-511): 8.23e-38: 148: 19.64		CUL3_HUMAN (8-780): 0: 743: 22.71
+	Hs
		1041477 CISH_HUMAN (320-552): 5.29e-56: 191: 24.90		CUL2_HUMAN (10-780): 0: 688: 26.37
+	Hs
		181856 SOCS1_HUMAN (370-552): 1.86e-48: 169: 23.50		CUL2_HUMAN (10-780): 0: 688: 26.37
+	Dm
		186280 O18683_DROME (369-520): 2.02e-36: 144: 21.29		CUL1_DROME (5-780): 0: 681: 26.30