HitPredict - High confidence protein-protein interactions

Interactor 1: PK3CD (O00329)
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (PI3-kinase subunit delta) (PI3K-delta) (PI3Kdelta) (PtdIns-3-kinase subunit delta) (EC 2.7.1.137) (EC 2.7.1.153) (Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta) (PtdIns-3-kinase subunit p110-delta) (p110delta)
Gene: PIK3CD

Interactor 2: PK3CD (O00329)
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (PI3-kinase subunit delta) (PI3K-delta) (PI3Kdelta) (PtdIns-3-kinase subunit delta) (EC 2.7.1.137) (EC 2.7.1.153) (Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta) (PtdIns-3-kinase subunit p110-delta) (p110delta)
Gene: PIK3CD

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	9113989
Identification Methods	in-gel kinase assay
Interaction Type	phosphorylation reaction

Property	Details
Interacting Pfam domains	PI3_PI4_kinase~PI3_PI4_kinase, PI3K_C2~PI3_PI4_kinase, PI3K_rbd~PI3_PI4_kinase, PI3Ka~PI3_PI4_kinase, PI3K_C2~PI3Ka, PI3K_rbd~PI3K_rbd, PI3K_rbd~PI3Ka
Common GO terms	GO:0001779 - natural killer cell differentiation GO:0001819 - positive regulation of cytokine production GO:0001938 - positive regulation of endothelial cell proliferation GO:0002250 - adaptive immune response GO:0002551 - mast cell chemotaxis and 41 others more... GO:0002679 - respiratory burst involved in defense response GO:0005524 - ATP binding GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0005942 - phosphatidylinositol 3-kinase complex GO:0005943 - phosphatidylinositol 3-kinase complex, class IA GO:0006468 - protein phosphorylation GO:0006954 - inflammatory response GO:0006955 - immune response GO:0007165 - signal transduction GO:0010595 - positive regulation of endothelial cell migration GO:0010628 - positive regulation of gene expression GO:0010818 - T cell chemotaxis GO:0016301 - kinase activity GO:0016303 - 1-phosphatidylinositol-3-kinase activity GO:0016310 - phosphorylation GO:0030101 - natural killer cell activation GO:0030183 - B cell differentiation GO:0030217 - T cell differentiation GO:0030335 - positive regulation of cell migration GO:0030593 - neutrophil chemotaxis GO:0033031 - positive regulation of neutrophil apoptotic process GO:0035005 - 1-phosphatidylinositol-4-phosphate 3-kinase activity GO:0035747 - natural killer cell chemotaxis GO:0035754 - B cell chemotaxis GO:0036092 - phosphatidylinositol-3-phosphate biosynthetic process GO:0038084 - vascular endothelial growth factor signaling pathway GO:0042110 - T cell activation GO:0042113 - B cell activation GO:0043303 - mast cell degranulation GO:0043491 - phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0045087 - innate immune response GO:0045766 - positive regulation of angiogenesis GO:0046934 - 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0048015 - phosphatidylinositol-mediated signaling GO:0050852 - T cell receptor signaling pathway GO:0050853 - B cell receptor signaling pathway GO:0060374 - mast cell differentiation GO:0072672 - neutrophil extravasation GO:1905278 - positive regulation of epithelial tube formation
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1	1044
Hs

1	1044

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Last updated: 15 Jul 2024