Protein: MECP2
Methyl-CpG-binding protein 2 (MeCp-2 protein) (MeCp2)

Gene: MECP2
Organism: Mus musculus
Interactions: 96
UniProt ID: Q9Z2D6

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000400 - four-way junction DNA binding
GO:0000785 - chromatin
GO:0000792 - heterochromatin
GO:0001662 - behavioral fear response

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

140322

HDAC1
Histone deacetylase 1

2

15

Small-scale

0.754

High

292424

HDAC3
Histone deacetylase 3

1

15

Small-scale

0.691

High

1143058

ATRX
Transcriptional regulator ATRX

3

20

Small-scale

0.670

High

1141066

SIN3A
Paired amphipathic helix protein Sin3a

3

6

Small-scale

0.656

High

1141980

NCOR1
Nuclear receptor corepressor 1

1

5

Small-scale

0.646

High

1111975

SMCA4
Transcription activator BRG1

3

20

Small-scale

0.633

High

1161026

SMRC2
SWI/SNF complex subunit SMARCC2

1

4

Small-scale

0.618

High

1378285

MBD3
Methyl-CpG-binding domain protein 3

1

9

Small-scale

0.618

High

1378286

MBD2
Methyl-CpG-binding domain protein 2

1

9

Small-scale

0.618

High

1321817

SMC1A
Structural maintenance of chromosomes protein 1A

2

3

Small-scale

0.611

High

1321832

SMC3
Structural maintenance of chromosomes protein 3

2

3

Small-scale

0.611

High

1157861

HDAC4
Histone deacetylase 4

1

16

Small-scale

0.575

High

250469

DHX9
ATP-dependent RNA helicase A

2

5

Small-scale

0.571

High

1150299

SMCA2
Probable global transcription activator SNF2L2

2

20

Small-scale

0.571

High

1321943

HNRPM
Heterogeneous nuclear ribonucleoprotein M

2

3

Small-scale

0.571

High

1142809

EWS
RNA-binding protein EWS

1

3

High-throughput

0.541

High

927935

HMGB1
High mobility group protein B1

1

13

Small-scale

0.536

High

1206590

TBL1R
F-box-like/WD repeat-containing protein TBL1XR1

1

11

Small-scale

0.536

High

1141985

FOXG1
Forkhead box protein G1

1

5

Small-scale

0.515

High

1322046

PHF14
PHD finger protein 14

1

7

Small-scale

0.515

High

1322284

TCF20
Transcription factor 20

1

14

Small-scale

0.515

High

70948

EP300
Histone acetyltransferase p300

1

13

Small-scale

0.501

High

193455

HNRH1
Heterogeneous nuclear ribonucleoprotein H

1

9

Small-scale

0.479

High

223108

SAP18
Histone deacetylase complex subunit SAP18

1

1

Small-scale

0.479

High

251002

SP3
Transcription factor Sp3

1

5

Small-scale

0.479

High

291741

DNM3A
DNA

1

5

Small-scale

0.479

High

292672

SP1
Transcription factor Sp1

1

5

Small-scale

0.479

High

372712

CFAD
Complement factor D

1

1

High-throughput

0.479

High

515260

KCC2A
Calcium/calmodulin-dependent protein kinase type II subunit alpha

1

4

Small-scale

0.479

High

659473

KCC2B
Calcium/calmodulin-dependent protein kinase type II subunit beta

1

4

Small-scale

0.479

High

788774

PURA
Transcriptional activator protein Pur-alpha

1

1

Small-scale

0.479

High

882706

FUS
RNA-binding protein FUS

1

5

Small-scale

0.479

High

928253

SUMO1
Small ubiquitin-related modifier 1

1

3

Small-scale

0.479

High

931979

CSK2B
Casein kinase II subunit beta

1

3

Small-scale

0.479

High

936575

HNRH2
Heterogeneous nuclear ribonucleoprotein H2

1

9

Small-scale

0.479

High

936743

TP53B
TP53-binding protein 1

1

8

Small-scale

0.479

High

949964

CBX1
Chromobox protein homolog 1

1

12

Small-scale

0.479

High

963097

HNRL2
Heterogeneous nuclear ribonucleoprotein U-like protein 2

1

8

Small-scale

0.479

High

964098

CREB1
Cyclic AMP-responsive element-binding protein 1

1

1

Small-scale

0.479

High

975170

CDK7
Cyclin-dependent kinase 7

1

3

Small-scale

0.479

High

1141955

RBBP4
Histone-binding protein RBBP4

1

11

Small-scale

0.479

High

1142599

SMRD1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1

1

2

Small-scale

0.479

High

1143051

CBX5
Chromobox protein homolog 5

1

11

Small-scale

0.479

High

1143213

NPM
Nucleophosmin

1

2

Small-scale

0.479

High

1157548

ANM6
Protein arginine N-methyltransferase 6

1

3

Small-scale

0.479

High

1160676

SMRD3
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3

1

2

Small-scale

0.479

High

1161544

KCC2D
Calcium/calmodulin-dependent protein kinase type II subunit delta

1

4

Small-scale

0.479

High

1194512

SAFB2
Scaffold attachment factor B2

1

3

Small-scale

0.479

High

1207272

Q8BTS0
Probable ATP-dependent RNA helicase DDX5

1

5

Small-scale

0.479

High

1225200

CHAP1
Chromosome alignment-maintaining phosphoprotein 1

1

5

Small-scale

0.479

High

1257624

P66B
Transcriptional repressor p66-beta

1

6

Small-scale

0.479

High

1265688

TADBP
TAR DNA-binding protein 43

1

7

Small-scale

0.479

High

1265850

SIR1
NAD-dependent protein deacetylase sirtuin-1

1

3

Small-scale

0.479

High

1265875

KCC2G
Calcium/calmodulin-dependent protein kinase type II subunit gamma

1

4

Small-scale

0.479

High

1307760

PSIP1
PC4 and SFRS1-interacting protein

1

8

Small-scale

0.479

High

1307769

SMRD2
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2

1

3

Small-scale

0.479

High

1307811

PRP19
Pre-mRNA-processing factor 19

1

7

Small-scale

0.479

High

1322181

Q9DCC5
Cbx3 protein

1

11

Small-scale

0.479

High

1378275

DEAF1
Deformed epidermal autoregulatory factor 1 homolog

1

2

Small-scale

0.479

High

1378277

HNRPC
Heterogeneous nuclear ribonucleoproteins C1/C2

1

4

Small-scale

0.479

High

1378287

HNRPF
Heterogeneous nuclear ribonucleoprotein F

1

8

Small-scale

0.479

High

911587

RS11
Small ribosomal subunit protein uS17

1

0

Small-scale

0.458

High

912779

SMD3
Small nuclear ribonucleoprotein Sm D3

1

0

Small-scale

0.458

High

985694

IF2P
Eukaryotic translation initiation factor 5B

1

0

Small-scale

0.458

High

1142062

LAP2B
Lamina-associated polypeptide 2, isoforms beta/delta/epsilon/gamma

1

0

Small-scale

0.458

High

1208030

Q8C839
Splicing factor 3B subunit 1

1

0

Small-scale

0.458

High

1225197

MATR3
Matrin-3

1

0

Small-scale

0.458

High

193503

O35846
Brm protein

1

9

Small-scale

0.457

High

139959

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

2

Small-scale

0.445

High

193280

HAP1
Huntingtin-associated protein 1

1

2

Small-scale

0.445

High

222685

SMCE1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1

1

9

Small-scale

0.445

High

291924

ROA2
Heterogeneous nuclear ribonucleoproteins A2/B1

1

10

Small-scale

0.445

High

440282

NFL
Neurofilament light polypeptide

1

8

Small-scale

0.445

High

449445

NUCL
Nucleolin

1

5

Small-scale

0.445

High

782412

KDM5C
Lysine-specific demethylase 5C

1

3

Small-scale

0.445

High

846403

RORA
Nuclear receptor ROR-alpha

1

7

Small-scale

0.445

High

957037

RBBP6
E3 ubiquitin-protein ligase RBBP6

1

8

Small-scale

0.445

High

981031

TOP1
DNA topoisomerase 1

1

2

Small-scale

0.445

High

1119394

DDX17
Probable ATP-dependent RNA helicase DDX17

1

5

Small-scale

0.445

High

1143002

DDX5
Probable ATP-dependent RNA helicase DDX5

1

5

Small-scale

0.445

High

1143622

DDX3X
ATP-dependent RNA helicase DDX3X

1

5

Small-scale

0.445

High

1152698

JADE3
Protein Jade-3

1

2

Small-scale

0.445

High

1206367

ROA3
Heterogeneous nuclear ribonucleoprotein A3

1

9

Small-scale

0.445

High

1207240

SRRM2
Serine/arginine repetitive matrix protein 2

1

10

Small-scale

0.445

High

1208043

MYEF2
Myelin expression factor 2

1

3

Small-scale

0.445

High

1257580

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

8

Small-scale

0.445

High

1257676

SFPQ
Splicing factor, proline- and glutamine-rich

1

6

Small-scale

0.445

High

1337475

ACINU
Apoptotic chromatin condensation inducer in the nucleus

1

5

Small-scale

0.445

High

1378288

TOP3B
DNA topoisomerase 3-beta-1

1

1

Small-scale

0.445

High

1225799

FNDC5
Fibronectin type III domain-containing protein 5

1

1

High-throughput

0.437

High

936553

TBX5
T-box transcription factor TBX5

1

0

Small-scale

0.426

High

1161375

MED16
Mediator of RNA polymerase II transcription subunit 16

1

0

Small-scale

0.426

High

1207279

CK5P1
Mitochondrial tRNA methylthiotransferase CDK5RAP1

1

0

Small-scale

0.426

High

1257656

SATB2
DNA-binding protein SATB2

1

0

Small-scale

0.426

High

1307976

PRP8
Pre-mRNA-processing-splicing factor 8

1

0

Small-scale

0.426

High

1337440

TMOD3
Tropomodulin-3

1

0

Small-scale

0.249

Low


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Last updated: 15 Jul 2024