HitPredict

Interactor 1: ZNRF4 (Q8WWF5)
E3 ubiquitin-protein ligase ZNRF4 (EC 2.3.2.27) (Nixin) (RING finger protein 204) (RING-type E3 ubiquitin transferase ZNRF4) (Zinc/RING finger protein 4)
Gene: ZNRF4

Interactor 2: OSBL8 (Q9BZF1)
Oxysterol-binding protein-related protein 8 (ORP-8) (OSBP-related protein 8)
Gene: OSBPL8

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005783 - endoplasmic reticulum GO:0005789 - endoplasmic reticulum membrane
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1 429 Hs			1 889
+	Hs
		1198675 SYVN1_HUMAN (143-374): 3.91e-31: 127: 13.93		OSBL8_HUMAN (1-889): 0: 1210: 100.00
+	Hs
		603077 ZNRF4_HUMAN (1-429): 2.35e-137: 402: 100.00		OSBP1_HUMAN (236-758): 1.11e-141: 441: 20.42
+	Hs
		603074 RN149_HUMAN (95-390): 4.12e-66: 218: 18.61		OSBP1_HUMAN (236-758): 1.11e-141: 441: 20.42