Protein: ETFA
Electron transfer flavoprotein subunit alpha, mitochondrial (Alpha-ETF)

Gene: ETFA
Organism: Homo sapiens
Interactions: 223
UniProt ID: P13804

Gene Ontology (top 5):
GO:0005739 - mitochondrion
GO:0005759 - mitochondrial matrix
GO:0009055 - electron transfer activity
GO:0009063 - amino acid catabolic process
GO:0016491 - oxidoreductase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

568370

ETFB
Electron transfer flavoprotein subunit beta

6

7

Small-scale

0.943

High

568436

ETFR1
Electron transfer flavoprotein regulatory factor 1

4

1

High-throughput

0.703

High

568438

CH082
UPF0598 protein C8orf82

4

0

High-throughput

0.664

High

568448

HSC20
Iron-sulfur cluster co-chaperone protein HscB

3

0

Small-scale

0.632

High

568357

ETFA
Electron transfer flavoprotein subunit alpha, mitochondrial

1

2

High-throughput

0.618

High

568363

IVD
Isovaleryl-CoA dehydrogenase, mitochondrial

1

3

High-throughput

0.618

High

568506

ACAD9
Complex I assembly factor ACAD9, mitochondrial

1

3

High-throughput

0.618

High

156420

ACPM
Acyl carrier protein, mitochondrial

2

0

High-throughput

0.585

High

568416

ICT1
Large ribosomal subunit protein mL62

2

0

High-throughput

0.585

High

568442

COX15
Heme A synthase COX15

2

0

High-throughput

0.585

High

279637

CISY
Citrate synthase, mitochondrial

2

2

High-throughput

0.584

High

348340

AIFM1
Apoptosis-inducing factor 1, mitochondrial

2

2

High-throughput

0.584

High

568419

FAKD3
FAST kinase domain-containing protein 3, mitochondrial

2

3

Small-scale

0.571

High

559853

COX41
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

2

0

High-throughput

0.559

High

568406

GRSF1
G-rich sequence factor 1

2

0

High-throughput

0.559

High

568508

SFXN1
Sideroflexin-1

2

0

High-throughput

0.559

High

563105

CFTR
Cystic fibrosis transmembrane conductance regulator

2

2

High-throughput

0.555

High

484356

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

1

High-throughput

0.536

High

528980

TAU
Microtubule-associated protein tau

1

1

High-throughput

0.536

High

568360

VDAC1
Non-selective voltage-gated ion channel VDAC1

1

1

High-throughput

0.536

High

568369

MP2K2
Dual specificity mitogen-activated protein kinase kinase 2

1

2

High-throughput

0.536

High

568471

COQ2
4-hydroxybenzoate polyprenyltransferase, mitochondrial

1

0

High-throughput

0.513

High

568414

HNRPD
Heterogeneous nuclear ribonucleoprotein D0

1

1

High-throughput

0.489

High

568490

KPCD2
Serine/threonine-protein kinase D2

1

1

High-throughput

0.489

High

281872

MPPB
Mitochondrial-processing peptidase subunit beta

1

3

High-throughput

0.479

High

287232

RF1M
Peptide chain release factor 1, mitochondrial

1

2

High-throughput

0.479

High

292066

S2512
Electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial

1

1

High-throughput

0.479

High

400218

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

1

High-throughput

0.479

High

403787

GCR
Glucocorticoid receptor

1

1

High-throughput

0.479

High

532328

CH60
60 kDa heat shock protein, mitochondrial

1

1

High-throughput

0.479

High

568362

ATPA
ATP synthase F(1) complex subunit alpha, mitochondrial

1

4

High-throughput

0.479

High

568371

HSPA9
Stress-70 protein, mitochondrial

1

3

High-throughput

0.479

High

568373

MDHM
Malate dehydrogenase, mitochondrial

1

3

High-throughput

0.479

High

568380

IF2M
Translation initiation factor IF-2, mitochondrial

1

2

High-throughput

0.479

High

568382

EFTU
Elongation factor Tu, mitochondrial

1

2

High-throughput

0.479

High

568400

KIF23
Kinesin-like protein KIF23

1

1

High-throughput

0.479

High

568404

QOR
Quinone oxidoreductase

1

1

High-throughput

0.479

High

568405

MPPA
Mitochondrial-processing peptidase subunit alpha

1

3

High-throughput

0.479

High

568408

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

3

High-throughput

0.479

High

568413

AUHM
Methylglutaconyl-CoA hydratase, mitochondrial

1

1

High-throughput

0.479

High

568422

TOM20
Mitochondrial import receptor subunit TOM20 homolog

1

1

High-throughput

0.479

High

568437

RUSD3
Mitochondrial mRNA pseudouridine synthase RPUSD3

1

1

High-throughput

0.479

High

568443

DHX30
ATP-dependent RNA helicase DHX30

1

1

High-throughput

0.479

High

568444

FAKD5
FAST kinase domain-containing protein 5, mitochondrial

1

3

High-throughput

0.479

High

568453

MCU
Calcium uniporter protein, mitochondrial

1

1

High-throughput

0.479

High

568459

ESR2
Estrogen receptor beta

1

1

High-throughput

0.479

High

568461

RRF2M
Ribosome-releasing factor 2, mitochondrial

1

2

High-throughput

0.479

High

568462

FAKD4
FAST kinase domain-containing protein 4

1

3

High-throughput

0.479

High

568463

MFRN2
Mitoferrin-2

1

2

High-throughput

0.479

High

568464

MCUR1
Mitochondrial calcium uniporter regulator 1

1

1

High-throughput

0.479

High

568465

RUSD4
Pseudouridylate synthase RPUSD4, mitochondrial

1

1

High-throughput

0.479

High

568466

TIM14
Mitochondrial import inner membrane translocase subunit TIM14

1

1

High-throughput

0.479

High

568470

DNJA3
DnaJ homolog subfamily A member 3, mitochondrial

1

2

High-throughput

0.479

High

568475

EFGM
Elongation factor G, mitochondrial

1

2

High-throughput

0.479

High

568478

PHB2
Prohibitin-2

1

2

High-throughput

0.479

High

568492

SLIRP
SRA stem-loop-interacting RNA-binding protein, mitochondrial

1

1

High-throughput

0.479

High

568493

CC90B
Coiled-coil domain-containing protein 90B, mitochondrial

1

1

High-throughput

0.479

High

568501

MTRFR
Mitochondrial translation release factor in rescue

1

2

High-throughput

0.479

High

568503

MTG2
Mitochondrial ribosome-associated GTPase 2

1

1

High-throughput

0.479

High

568515

MCUB
Calcium uniporter regulatory subunit MCUb, mitochondrial

1

1

High-throughput

0.479

High

568518

FAKD2
FAST kinase domain-containing protein 2, mitochondrial

1

3

High-throughput

0.479

High

568522

RF1ML
Peptide chain release factor 1-like, mitochondrial

1

2

High-throughput

0.479

High

568531

DJC15
DnaJ homolog subfamily C member 15

1

1

High-throughput

0.479

High

568532

MTCH2
Mitochondrial carrier homolog 2

1

2

High-throughput

0.479

High

568391

CDC42
Cell division control protein 42 homolog

1

2

High-throughput

0.464

High

568372

VHL
von Hippel-Lindau disease tumor suppressor

1

0

Small-scale

0.460

High

568383

PSN1
Presenilin-1

1

0

Small-scale

0.460

High

61415

VWA8
von Willebrand factor A domain-containing protein 8

1

0

High-throughput

0.458

High

66123

MET15
12S rRNA N(4)-cytidine methyltransferase METTL15

1

0

High-throughput

0.458

High

143543

PPP6
Serine/threonine-protein phosphatase 6 catalytic subunit

1

0

High-throughput

0.458

High

183583

RT12
Small ribosomal subunit protein uS12m

1

0

High-throughput

0.458

High

209463

SERA
D-3-phosphoglycerate dehydrogenase

1

0

Small-scale

0.458

High

240633

PRKN
E3 ubiquitin-protein ligase parkin

1

0

High-throughput

0.458

High

283785

NDUS3
NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial

1

0

High-throughput

0.458

High

296189

SCO1
Protein SCO1 homolog, mitochondrial

1

0

High-throughput

0.458

High

322195

GLSK
Glutaminase kidney isoform, mitochondrial

1

0

High-throughput

0.458

High

350779

TRUB2
Pseudouridylate synthase TRUB2, mitochondrial

1

0

High-throughput

0.458

High

361599

OTC
Ornithine transcarbamylase, mitochondrial

1

0

High-throughput

0.458

High

411284

NTRK1
High affinity nerve growth factor receptor

1

0

High-throughput

0.458

High

470835

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

0

High-throughput

0.458

High

519042

COX8A
Cytochrome c oxidase subunit 8A, mitochondrial

1

0

High-throughput

0.458

High

568365

3MG
DNA-3-methyladenine glycosylase

1

0

High-throughput

0.458

High

568376

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

0

High-throughput

0.458

High

568379

EFTS
Elongation factor Ts, mitochondrial

1

0

High-throughput

0.458

High

568399

TFAM
Transcription factor A, mitochondrial

1

0

High-throughput

0.458

High

568401

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

0

High-throughput

0.458

High

568402

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

0

High-throughput

0.458

High

568409

NNTM
NAD(P) transhydrogenase, mitochondrial

1

0

High-throughput

0.458

High

568412

APR
Phorbol-12-myristate-13-acetate-induced protein 1

1

0

High-throughput

0.458

High

568421

PDK1
[Pyruvate dehydrogenase

1

0

High-throughput

0.458

High

568423

SURF1
Surfeit locus protein 1

1

0

High-throughput

0.458

High

568427

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

1

0

High-throughput

0.458

High

568430

SYAM
Alanine--tRNA ligase, mitochondrial

1

0

High-throughput

0.458

High

568435

MRM1
rRNA methyltransferase 1, mitochondrial

1

0

High-throughput

0.458

High

568447

DYR2
Dihydrofolate reductase 2, mitochondrial

1

0

High-throughput

0.458

High

568458

AKAP1
A-kinase anchor protein 1, mitochondrial

1

0

High-throughput

0.458

High

568467

RRFM
Ribosome-recycling factor, mitochondrial

1

0

High-throughput

0.458

High

568468

MTEF3
Transcription termination factor 3, mitochondrial

1

0

High-throughput

0.458

High

568472

COX14
Cytochrome c oxidase assembly protein COX14

1

0

High-throughput

0.458

High

568474

TEFM
Transcription elongation factor, mitochondrial

1

0

High-throughput

0.458

High

568476

IMP2L
Mitochondrial inner membrane protease subunit 2

1

0

High-throughput

0.458

High

568481

TACO1
Translational activator of cytochrome c oxidase 1

1

0

High-throughput

0.458

High

568482

CQ080
Mitochondrial nucleoid-associated protein 1

1

0

High-throughput

0.458

High

568483

MTG1
Mitochondrial ribosome-associated GTPase 1

1

0

High-throughput

0.458

High

568484

TMM70
Transmembrane protein 70, mitochondrial

1

0

High-throughput

0.458

High

568485

TR61B
tRNA

1

0

High-throughput

0.458

High

568487

HINT2
Adenosine 5'-monophosphoramidase HINT2

1

0

High-throughput

0.458

High

568489

RT26
Small ribosomal subunit protein mS26

1

0

High-throughput

0.458

High

568500

IF3M
Translation initiation factor IF-3, mitochondrial

1

0

High-throughput

0.458

High

568505

MET17
Ribosome assembly protein METTL17, mitochondrial

1

0

High-throughput

0.458

High

568510

NGRN
Neugrin

1

0

High-throughput

0.458

High

568514

EXD2
Exonuclease 3'-5' domain-containing protein 2

1

0

High-throughput

0.458

High

568516

RMND1
Required for meiotic nuclear division protein 1 homolog

1

0

High-throughput

0.458

High

568517

AKIP
Small ribosomal subunit protein mS38

1

0

High-throughput

0.458

High

568519

MRES1
Mitochondrial transcription rescue factor 1

1

0

High-throughput

0.458

High

568527

COQ6
Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial

1

0

High-throughput

0.458

High

568528

RM11
Large ribosomal subunit protein uL11m

1

0

High-throughput

0.458

High

568431

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

1

High-throughput

0.445

High

156905

CTRO
Citron Rho-interacting kinase

1

1

High-throughput

0.437

High

188805

TMPS2
Transmembrane protease serine 2

1

1

High-throughput

0.437

High

227346

SPOP
Speckle-type POZ protein

1

1

High-throughput

0.437

High

258747

DNJA2
DnaJ homolog subfamily A member 2

1

2

High-throughput

0.437

High

330622

KI20A
Kinesin-like protein KIF20A

1

2

High-throughput

0.437

High

373752

RASN
GTPase NRas

1

1

High-throughput

0.437

High

568364

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

1

High-throughput

0.437

High

568377

LIS1
Platelet-activating factor acetylhydrolase IB subunit beta

1

2

High-throughput

0.437

High

568392

RHOA
Transforming protein RhoA

1

2

High-throughput

0.437

High

568393

WDR5
WD repeat-containing protein 5

1

2

High-throughput

0.437

High

568398

RHOG
Rho-related GTP-binding protein RhoG

1

2

High-throughput

0.437

High

568403

DHX9
ATP-dependent RNA helicase A

1

1

Small-scale

0.437

High

568417

RBM39
RNA-binding protein 39

1

1

High-throughput

0.437

High

568429

DUS28
Dual specificity phosphatase 28

1

1

High-throughput

0.437

High

568439

FGD5
FYVE, RhoGEF and PH domain-containing protein 5

1

1

High-throughput

0.437

High

568455

DCA11
DDB1- and CUL4-associated factor 11

1

2

High-throughput

0.437

High

568456

STYX
Serine/threonine/tyrosine-interacting protein

1

1

High-throughput

0.437

High

568491

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

1

High-throughput

0.437

High

568499

EHD4
EH domain-containing protein 4

1

1

High-throughput

0.437

High

568513

TMPS4
Transmembrane protease serine 4

1

1

High-throughput

0.437

High

568524

ANC2
Anaphase-promoting complex subunit 2

1

1

High-throughput

0.437

High

568529

AAKB1
5'-AMP-activated protein kinase subunit beta-1

1

1

High-throughput

0.437

High

568358

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

0

High-throughput

0.426

High

568533

SIR4
NAD-dependent protein lipoamidase sirtuin-4, mitochondrial

1

0

High-throughput

0.426

High

568452

MOT11
Monocarboxylate transporter 11

1

2

High-throughput

0.407

High

568374

CCNF
Cyclin-F

2

0

High-throughput

0.305

High

568389

TERA
Transitional endoplasmic reticulum ATPase

2

0

High-throughput

0.298

High

213791

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

0

High-throughput

0.279

Low

371054

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.279

Low

568366

KAP1
cAMP-dependent protein kinase type I-beta regulatory subunit

1

0

High-throughput

0.279

Low

568368

SOAT1
Sterol O-acyltransferase 1

1

0

High-throughput

0.279

Low

568385

IRAK1
Interleukin-1 receptor-associated kinase 1

1

0

High-throughput

0.279

Low

568387

SPSY
Spermine synthase

1

0

High-throughput

0.279

Low

568394

ACTA
Actin, aortic smooth muscle

1

0

High-throughput

0.279

Low

568407

EPS8
Epidermal growth factor receptor kinase substrate 8

1

0

High-throughput

0.279

Low

568469

SGTB
Small glutamine-rich tetratricopeptide repeat-containing protein beta

1

0

High-throughput

0.279

Low

568480

ATGA1
Autophagy-related protein 101

1

0

High-throughput

0.279

Low

568486

DDA1
DET1- and DDB1-associated protein 1

1

0

High-throughput

0.279

Low

568494

UBA5
Ubiquitin-like modifier-activating enzyme 5

1

0

High-throughput

0.279

Low

568509

EXOS4
Exosome complex component RRP41

1

0

High-throughput

0.279

Low

352914

AGR2
Anterior gradient protein 2 homolog

1

0

High-throughput

0.269

Low

568426

HSPB2
Heat shock protein beta-2

1

0

High-throughput

0.265

Low

568521

FXL17
F-box/LRR-repeat protein 17

1

0

Small-scale

0.251

Low

164236

NRP1
Neuropilin-1

1

0

High-throughput

0.249

Low

254515

EIF1B
Eukaryotic translation initiation factor 1b

1

0

High-throughput

0.249

Low

293140

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.249

Low

349771

SNAI1
Zinc finger protein SNAI1

1

0

High-throughput

0.249

Low

352311

TOP3B
DNA topoisomerase 3-beta-1

1

0

High-throughput

0.249

Low

439929

LCK
Tyrosine-protein kinase Lck

1

0

High-throughput

0.249

Low

536410

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.249

Low

568359

IF2B
Eukaryotic translation initiation factor 2 subunit 2

1

0

High-throughput

0.249

Low

568361

CRCM
Colorectal mutant cancer protein

1

0

High-throughput

0.249

Low

568367

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

568375

PERI
Peripherin

1

0

High-throughput

0.249

Low

568378

NAMPT
Nicotinamide phosphoribosyltransferase

1

0

High-throughput

0.249

Low

568381

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.249

Low

568384

CDK7
Cyclin-dependent kinase 7

1

0

High-throughput

0.249

Low

568386

NEK3
Serine/threonine-protein kinase Nek3

1

0

High-throughput

0.249

Low

568388

SNAA
Alpha-soluble NSF attachment protein

1

0

High-throughput

0.249

Low

568390

IF6
Eukaryotic translation initiation factor 6

1

0

High-throughput

0.249

Low

568395

RL31
Large ribosomal subunit protein eL31

1

0

High-throughput

0.249

Low

568396

DYLT1
Dynein light chain Tctex-type 1

1

0

High-throughput

0.249

Low

568397

ELF3
ETS-related transcription factor Elf-3

1

0

High-throughput

0.249

Low

568410

BIRC3
Baculoviral IAP repeat-containing protein 3

1

0

High-throughput

0.249

Low

568411

CUL3
Cullin-3

1

0

High-throughput

0.249

Low

568415

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

0

High-throughput

0.249

Low

568418

CUL7
Cullin-7

1

0

High-throughput

0.249

Low

568420

KIF14
Kinesin-like protein KIF14

1

0

High-throughput

0.249

Low

568424

EZH2
Histone-lysine N-methyltransferase EZH2

1

0

High-throughput

0.249

Low

568425

ZYX
Zyxin

1

0

High-throughput

0.249

Low

568428

ANR55
Ankyrin repeat domain-containing protein 55

1

0

High-throughput

0.249

Low

568432

TET5C
Terminal nucleotidyltransferase 5C

1

0

High-throughput

0.249

Low

568433

VIR
Protein virilizer homolog

1

0

High-throughput

0.249

Low

568434

LTOR1
Ragulator complex protein LAMTOR1

1

0

High-throughput

0.249

Low

568441

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

568445

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.249

Low

568446

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.249

Low

568449

NIN
Ninein

1

0

High-throughput

0.249

Low

568450

EMC1
ER membrane protein complex subunit 1

1

0

High-throughput

0.249

Low

568451

SERB1
SERPINE1 mRNA-binding protein 1

1

0

High-throughput

0.249

Low

568454

TNIP2
TNFAIP3-interacting protein 2

1

0

High-throughput

0.249

Low

568457

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

0

High-throughput

0.249

Low

568460

REQU
Zinc finger protein ubi-d4

1

0

High-throughput

0.249

Low

568473

CI072
Guanine nucleotide exchange factor C9orf72

1

0

High-throughput

0.249

Low

568477

DNJC7
DnaJ homolog subfamily C member 7

1

0

High-throughput

0.249

Low

568479

BAG1
BAG family molecular chaperone regulator 1

1

0

High-throughput

0.249

Low

568488

ACE2
Angiotensin-converting enzyme 2

1

0

High-throughput

0.249

Low

568495

SPRTN
DNA-dependent metalloprotease SPRTN

1

0

High-throughput

0.249

Low

568496

CCDC8
Coiled-coil domain-containing protein 8

1

0

High-throughput

0.249

Low

568497

UN93B
Protein unc-93 homolog B1

1

0

High-throughput

0.249

Low

568498

ATG5
Autophagy protein 5

1

0

High-throughput

0.249

Low

568502

CHM4B
Charged multivesicular body protein 4b

1

0

High-throughput

0.249

Low

568504

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.249

Low

568507

ECT2
Protein ECT2

1

0

High-throughput

0.249

Low

568511

ANLN
Anillin

1

0

High-throughput

0.249

Low

568520

TRM7
tRNA

1

0

High-throughput

0.249

Low

568523

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.249

Low

568525

CLC4E
C-type lectin domain family 4 member E

1

0

High-throughput

0.249

Low

568526

HDAC5
Histone deacetylase 5

1

0

High-throughput

0.249

Low

568530

TRAF6
TNF receptor-associated factor 6

1

0

High-throughput

0.249

Low

248832

GSDME
Gasdermin-E

1

0

High-throughput

0.232

Low

429221

JUN
Transcription factor Jun

1

0

High-throughput

0.232

Low

568440

SO4C1
Solute carrier organic anion transporter family member 4C1

1

0

High-throughput

0.232

Low

568512

S17A5
Sialin

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025