HitPredict

Interactor 1: ODPX (O00330)
Pyruvate dehydrogenase protein X component, mitochondrial (Dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex) (E3-binding protein) (E3BP) (Lipoyl-containing pyruvate dehydrogenase complex component X) (proX)
Gene: PDHX

Interactor 2: SIR4 (Q9Y6E7)
NAD-dependent protein lipoamidase sirtuin-4, mitochondrial (EC 2.3.1.-) (NAD-dependent ADP-ribosyltransferase sirtuin-4) (EC 2.4.2.-) (NAD-dependent protein biotinylase sirtuin-4) (EC 2.3.1.-) (NAD-dependent protein deacetylase sirtuin-4) (EC 2.3.1.286) (Regulatory protein SIR2 homolog 4) (SIR2-like protein 4)
Gene: SIRT4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.50	0.60	0.550

Property	Details
Experiments	25525879
Identification Methods	anti tag coimmunoprecipitation, lipoprotein cleavage assay
Interaction Type	association, lipoprotein cleavage reaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005739 - mitochondrion GO:0005759 - mitochondrial matrix
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 501 Hs			1 314
+	Hs
		506090 ODB2_HUMAN (1-500): 2.22e-155: 452: 24.56		SIR4_HUMAN (1-314): 1.07e-143: 409: 100.00
+	Hs
		739369 ODO2_HUMAN (19-500): 2.29e-128: 382: 22.93		SIR4_HUMAN (1-314): 1.07e-143: 409: 100.00
+	Hs
		489844 ODP2_HUMAN (11-277): 8.66e-33: 134: 21.50		SIR4_HUMAN (1-314): 1.07e-143: 409: 100.00
+	Hs
		489826 ODP2_HUMAN (11-277): 8.66e-33: 134: 21.50		SIR3_HUMAN (39-312): 8.61e-87: 267: 27.34
+	Hs
		489825 ODP2_HUMAN (11-277): 8.66e-33: 134: 21.50		SIR7_HUMAN (29-311): 9.49e-74: 234: 26.46