HitPredict

Interactor 1: EED (Q921E6)
Polycomb protein EED
Gene: EED

Interactor 2: CPSF1 (Q9EPU4)
Cleavage and polyadenylation specificity factor subunit 1 (Cleavage and polyadenylation specificity factor 160 kDa subunit) (CPSF 160 kDa subunit)
Gene: CPSF1

Species: Mus musculus

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	24457600
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	CPSF_A~WD40, MMS1_N~WD40
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 441 Mm			1 1441
+	Hs
		268047 EED_HUMAN (1-441): 2.11e-92: 287: 100.00		CPSF1_HUMAN (1-1441): 0: 1551: 96.54
+	Hs
		1014208 NLE1_HUMAN (4-124): 2.95e-18: 88.8: 9.09		CPSF1_HUMAN (1-1441): 0: 1551: 96.54
+	Hs
		1014128 TAF5_HUMAN (173-441): 4.8e-16: 82.5: 21.19		CPSF1_HUMAN (1-1441): 0: 1551: 96.54
+	Hs
		197009 PRP4_HUMAN (337-437): 3.12e-09: 60.7: 16.51		CPSF1_HUMAN (1-1441): 0: 1551: 96.54
+	Mm
		1265380 EED_MOUSE (1-441): 2.11e-92: 287: 100.00		SF3B3_MOUSE (333-1440): 0: 573: 13.58
+	Hs
		268108 EED_HUMAN (1-441): 2.11e-92: 287: 100.00		SF3B3_HUMAN (333-1440): 0: 573: 13.58
+	Hs
		1073094 FBXW7_HUMAN (219-439): 1.18e-27: 118: 15.32		SF3B3_HUMAN (333-1440): 0: 573: 13.58
+	Hs
		1073168 NLE1_HUMAN (4-124): 2.95e-18: 88.8: 9.09		SF3B3_HUMAN (333-1440): 0: 573: 13.58
+	Hs
		268118 EED_HUMAN (1-441): 2.11e-92: 287: 100.00		DDB1_HUMAN (2-636): 7.11e-77: 280: 15.40
+	Mm
		1112293 EED_MOUSE (1-441): 2.11e-92: 287: 100.00		DDB1_MOUSE (2-636): 3.12e-76: 278: 15.40
+	Hs
		245605 TBL1X_HUMAN (13-441): 1.12e-73: 243: 11.39		DDB1_HUMAN (2-636): 7.11e-77: 280: 15.40
+	Hs
		1082374 TBL1R_HUMAN (4-335): 2.6e-56: 195: 11.40		DDB1_HUMAN (2-636): 7.11e-77: 280: 15.40
+	Hs
		1082327 SNR40_HUMAN (298-441): 8.27e-22: 98: 14.29		DDB1_HUMAN (2-636): 7.11e-77: 280: 15.40
+	Hs
		1082263 WDR5B_HUMAN (279-439): 2.9e-21: 96.1: 12.27		DDB1_HUMAN (2-636): 7.11e-77: 280: 15.40
+	Hs
		1082480 WSB1_HUMAN (162-437): 7.57e-17: 84: 21.35		DDB1_HUMAN (2-636): 7.11e-77: 280: 15.40
+	Hs
		903254 WDR5_HUMAN (335-440): 3.22e-14: 75.3: 15.09		DDB1_HUMAN (2-636): 7.11e-77: 280: 15.40