Protein: DFFA
DNA fragmentation factor subunit alpha (DNA fragmentation factor 45 kDa subunit) (DFF-45) (Inhibitor of CAD) (ICAD)

Gene: DFFA
Organism: Homo sapiens
Interactions: 54
UniProt ID: O00273

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005829 - cytosol
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

130816

DFFB
DNA fragmentation factor subunit beta

11

4

Small-scale

0.976

High

130860

CIDEB
Lipid transferase CIDEB

1

13

Small-scale

0.647

High

130861

TSYL4
Testis-specific Y-encoded-like protein 4

3

0

High-throughput

0.638

High

130813

DFFA
DNA fragmentation factor subunit alpha

1

13

High-throughput

0.618

High

130835

1433Z
14-3-3 protein zeta/delta

2

3

High-throughput

0.612

High

130834

1433G
14-3-3 protein gamma

2

3

High-throughput

0.601

High

130842

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

3

0

Small-scale

0.597

High

130829

CASP3
Caspase-3

2

3

Small-scale

0.585

High

130815

BRD4
Bromodomain-containing protein 4

2

1

High-throughput

0.584

High

130819

HSPB1
Heat shock protein beta-1

1

1

High-throughput

0.582

High

130820

GRAB
Granzyme B

1

3

Small-scale

0.550

High

130836

EWS
RNA-binding protein EWS

1

1

High-throughput

0.541

High

130831

AAPK2
5'-AMP-activated protein kinase catalytic subunit alpha-2

1

1

High-throughput

0.536

High

130841

BAK
Bcl-2 homologous antagonist/killer

1

1

High-throughput

0.515

High

130822

FPPS
Farnesyl pyrophosphate synthase

1

0

High-throughput

0.513

High

130830

GRAM
Granzyme M

1

3

Small-scale

0.502

High

130833

CASP7
Caspase-7

1

3

Small-scale

0.501

High

130826

CRCM
Colorectal mutant cancer protein

1

0

High-throughput

0.493

High

130849

NP1L5
Nucleosome assembly protein 1-like 5

1

0

High-throughput

0.493

High

130864

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

1

0

High-throughput

0.493

High

130862

AGO2
Protein argonaute-2

1

1

Small-scale

0.481

High

130818

NTRK1
High affinity nerve growth factor receptor

1

1

High-throughput

0.479

High

130827

1433T
14-3-3 protein theta

1

3

High-throughput

0.479

High

130828

1433B
14-3-3 protein beta/alpha

1

3

High-throughput

0.479

High

130854

GBB4
Guanine nucleotide-binding protein subunit beta-4

1

1

High-throughput

0.479

High

130844

NECA2
N-terminal EF-hand calcium-binding protein 2

1

0

High-throughput

0.460

High

130814

PRKN
E3 ubiquitin-protein ligase parkin

1

0

High-throughput

0.458

High

130823

HNRPL
Heterogeneous nuclear ribonucleoprotein L

1

0

High-throughput

0.458

High

130824

CEBPB
CCAAT/enhancer-binding protein beta

1

0

High-throughput

0.458

High

130837

BIRC3
Baculoviral IAP repeat-containing protein 3

1

0

High-throughput

0.458

High

130838

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

0

High-throughput

0.458

High

130839

HERC1
Probable E3 ubiquitin-protein ligase HERC1

1

0

High-throughput

0.458

High

130840

NF2L2
Nuclear factor erythroid 2-related factor 2

1

0

Small-scale

0.458

High

130848

TITIN
Titin

1

0

High-throughput

0.458

High

130852

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

130859

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

130863

DUS12
Dual specificity protein phosphatase 12

1

0

High-throughput

0.458

High

130832

TERA
Transitional endoplasmic reticulum ATPase

1

1

High-throughput

0.445

High

130817

PRIO
Major prion protein

1

0

High-throughput

0.426

High

130845

DND1
Dead end protein homolog 1

1

0

High-throughput

0.426

High

130846

SPPL3
Signal peptide peptidase-like 3

1

0

High-throughput

0.426

High

130847

TCP1L
T-complex protein 10A homolog 1

1

0

High-throughput

0.426

High

130850

F111A
Serine protease FAM111A

1

0

High-throughput

0.426

High

130851

ZDHC5
Palmitoyltransferase ZDHHC5

1

0

High-throughput

0.426

High

130853

SH24A
SH2 domain-containing protein 4A

1

0

High-throughput

0.426

High

130857

DDX28
Probable ATP-dependent RNA helicase DDX28

1

0

High-throughput

0.426

High

130825

GRAH
Granzyme H

1

3

Small-scale

0.407

High

130855

LFG4
Protein lifeguard 4

1

0

High-throughput

0.269

Low

104804

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

130821

CP4B1
Cytochrome P450 4B1

1

0

High-throughput

0.249

Low

130843

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

130856

STRN4
Striatin-4

1

0

High-throughput

0.238

Low

130858

UVRAG
UV radiation resistance-associated gene protein

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025