HitPredict

Interactor 1: SHC3 (Q92529)
SHC-transforming protein 3 (Neuronal Shc) (N-Shc) (Protein Rai) (SHC-transforming protein C) (Src homology 2 domain-containing-transforming protein C3) (SH2 domain protein C3)
Gene: SHC3

Interactor 2: TSC1 (Q92574)
Hamartin (Tuberous sclerosis 1 protein)
Gene: TSC1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.481

Property	Details
Experiments	32296183
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 594 Hs			1 1164
+	Hs
		1203618 SHC3_HUMAN (1-594): 0: 587: 100.00		Q86WV8_HUMAN (1-343): 3.4e-177: 526: 100.00
+	Hs
		666020 SHC1_HUMAN (3-593): 5.76e-176: 512: 46.65		MYH11_HUMAN (392-1122): 2.73e-28: 126: 8.64
+	Hs
		666018 SHC1_HUMAN (3-593): 5.76e-176: 512: 46.65		MYH9_HUMAN (673-1164): 1.25e-23: 111: 12.40
+	Hs
		666132 SHC1_HUMAN (3-593): 5.76e-176: 512: 46.65		MYH14_HUMAN (620-918): 1.78e-11: 71.1: 13.11
+	Hs
		666019 SHC1_HUMAN (3-593): 5.76e-176: 512: 46.65		MYH10_HUMAN (687-992): 3.26e-09: 63.6: 20.43
+	Mm
		936588 ANS1B_MOUSE (11-331): 1.47e-68: 243: 17.68		ROCK2_MOUSE (415-1021): 2.16e-25: 116: 11.09
+	Hs
		275589 BCAR3_HUMAN (342-592): 6.06e-51: 190: 21.13		MY18A_HUMAN (461-1064): 4e-25: 115: 10.31
+	Hs
		111443 J3QRU1_HUMAN (355-594): 1.49e-48: 179: 17.31		MYH9_HUMAN (673-1164): 1.25e-23: 111: 12.40
+	Hs
		433272 YES_HUMAN (355-594): 1.37e-48: 179: 17.31		MYH9_HUMAN (673-1164): 1.25e-23: 111: 12.40
+	Hs
		412287 FYN_HUMAN (438-585): 3.12e-44: 167: 20.76		MY18A_HUMAN (461-1064): 4e-25: 115: 10.31
+	Hs
		412058 FYN_HUMAN (438-585): 3.12e-44: 167: 20.76		MYH9_HUMAN (673-1164): 1.25e-23: 111: 12.40
+	Hs
		523231 SRC_HUMAN (361-594): 3.73e-49: 181: 18.18		MYH4_HUMAN (393-969): 2.58e-19: 96.8: 11.22
+	Hs
		433620 LYN_HUMAN (404-594): 8.1e-44: 165: 20.69		MYH9_HUMAN (673-1164): 1.25e-23: 111: 12.40
+	Hs
		411983 FYN_HUMAN (438-585): 3.12e-44: 167: 20.76		DESP_HUMAN (570-1151): 1.05e-21: 104: 11.54
+	Hs
		433558 LYN_HUMAN (404-594): 8.1e-44: 165: 20.69		DESP_HUMAN (570-1151): 1.05e-21: 104: 11.54
+	Hs
		433818 LYN_HUMAN (404-594): 8.1e-44: 165: 20.69		MRCKA_HUMAN (278-842): 4.78e-17: 89.1: 8.78
+	Hs
		426943 FES_HUMAN (431-594): 4.92e-36: 146: 22.56		DESP_HUMAN (570-1151): 1.05e-21: 104: 11.54
+	Hs
		434101 LYN_HUMAN (404-594): 8.1e-44: 165: 20.69		MRCKB_HUMAN (835-1162): 1.41e-15: 84.5: 6.67
+	Hs
		433749 LYN_HUMAN (404-594): 8.1e-44: 165: 20.69		ROCK1_HUMAN (433-926): 6.18e-15: 82.2: 12.00
+	Hs
		433808 LYN_HUMAN (404-594): 8.1e-44: 165: 20.69		CYTSB_HUMAN (740-1117): 1.86e-12: 74.1: 12.41