Interactor 1: SORL (Q92673)
Sortilin-related receptor (Low-density lipoprotein receptor relative with 11 ligand-binding repeats) (LDLR relative with 11 ligand-binding repeats) (LR11) (SorLA-1) (Sorting protein-related receptor containing LDLR class A repeats) (SorLA)
Gene: SORL1

Interactor 2: SORL (Q92673)
Sortilin-related receptor (Low-density lipoprotein receptor relative with 11 ligand-binding repeats) (LDLR relative with 11 ligand-binding repeats) (LR11) (SorLA-1) (Sorting protein-related receptor containing LDLR class A repeats) (SorLA)
Gene: SORL1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.82 1.00 0.907

The method score is based on:

Property Details
Experiments 11294867, 26858303, 28265003, 23333276
Identification Methods pull down, surface plasmon resonance
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains fn3~fn3, Ldl_recept_a~Ldl_recept_a, Ldl_recept_a~Ldl_recept_b, Ldl_recept_b~Ldl_recept_b, Sortilin-Vps10~Sortilin-Vps10, Sortilin_C~Sortilin-Vps10
Common GO terms GO:0000139 - Golgi membrane
GO:0001540 - amyloid-beta binding
GO:0002024 - diet induced thermogenesis
GO:0004888 - transmembrane signaling receptor activity
GO:0005041 - low-density lipoprotein particle receptor activity
and 55 others

more...

Homologous interactions 15

Homologous interactions

Color coding for hit scores

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Hs

1 2214
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Last updated: 15 Jul 2024