Protein: TBCD4
TBC1 domain family member 4 (Akt substrate of 160 kDa) (AS160)

Gene: TBCD4, TBC1D4
Organism: Homo sapiens
Interactions: 133
UniProt ID: O60343

Gene Ontology (top 5):
GO:0005096 - GTPase activator activity
GO:0005794 - Golgi apparatus
GO:0005829 - cytosol
GO:0016192 - vesicle-mediated transport
GO:0031339 - negative regulation of vesicle fusion

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

247147

APBB2
Amyloid beta precursor protein binding family B member 2

3

1

High-throughput

0.861

High

247104

1433Z
14-3-3 protein zeta/delta

7

20

Small-scale

0.742

High

247088

1433B
14-3-3 protein beta/alpha

6

20

High-throughput

0.730

High

247109

1433F
14-3-3 protein eta

5

20

High-throughput

0.716

High

247082

1433T
14-3-3 protein theta

5

20

Small-scale

0.712

High

247099

1433G
14-3-3 protein gamma

4

20

High-throughput

0.699

High

247101

1433E
14-3-3 protein epsilon

4

3

High-throughput

0.697

High

247133

TBCD1
TBC1 domain family member 1

1

9

High-throughput

0.691

High

247144

RAB2B
Ras-related protein Rab-2B

1

20

High-throughput

0.691

High

247079

CCNA2
Cyclin-A2

3

1

High-throughput

0.667

High

247085

TMOD1
Tropomodulin-1

3

1

High-throughput

0.667

High

240218

PRKN
E3 ubiquitin-protein ligase parkin

3

7

High-throughput

0.640

High

247139

IF4E3
Eukaryotic translation initiation factor 4E type 3

3

0

High-throughput

0.638

High

247080

MYF6
Myogenic factor 6

2

1

High-throughput

0.628

High

247178

FBW1B
F-box/WD repeat-containing protein 11

2

2

High-throughput

0.624

High

158538

CTDS2
Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2

3

2

High-throughput

0.609

High

247150

T53I1
Tumor protein p53-inducible nuclear protein 1

2

0

High-throughput

0.602

High

247094

GSK3A
Glycogen synthase kinase-3 alpha

2

4

High-throughput

0.601

High

247097

CDC42
Cell division control protein 42 homolog

1

20

Small-scale

0.590

High

247093

CCNF
Cyclin-F

2

3

High-throughput

0.584

High

247181

FBW1A
F-box/WD repeat-containing protein 1A

2

2

High-throughput

0.584

High

247127

LRC8E
Volume-regulated anion channel subunit LRRC8E

2

1

High-throughput

0.574

High

247173

TMOD3
Tropomodulin-3

2

1

High-throughput

0.574

High

247138

FAM9B
Protein FAM9B

2

1

High-throughput

0.549

High

247176

NRBP
Nuclear receptor-binding protein

2

1

High-throughput

0.549

High

247062

DJC13
DnaJ homolog subfamily C member 13

1

4

High-throughput

0.536

High

247078

NCF2
Neutrophil cytosol factor 2

1

3

High-throughput

0.536

High

247102

PP2AB
Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform

1

2

High-throughput

0.536

High

247105

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

1

2

High-throughput

0.536

High

247113

KCC2G
Calcium/calmodulin-dependent protein kinase type II subunit gamma

1

1

High-throughput

0.536

High

247114

CUL2
Cullin-2

1

4

High-throughput

0.536

High

247158

MPP8
M-phase phosphoprotein 8

1

2

High-throughput

0.536

High

247162

UBXN6
UBX domain-containing protein 6

1

2

High-throughput

0.536

High

247171

ARL8B
ADP-ribosylation factor-like protein 8B

1

12

High-throughput

0.536

High

247087

AKT1
RAC-alpha serine/threonine-protein kinase

1

0

Small-scale

0.527

High

219102

LTOR5
Ragulator complex protein LAMTOR5

1

0

High-throughput

0.518

High

247089

1433S
14-3-3 protein sigma

1

20

High-throughput

0.515

High

247095

GSK3B
Glycogen synthase kinase-3 beta

1

4

High-throughput

0.515

High

247103

RL40
Ubiquitin-ribosomal protein eL40 fusion protein

1

2

High-throughput

0.515

High

247119

H2B2E
Histone H2B type 2-E

1

1

High-throughput

0.515

High

247149

H2B1H
Histone H2B type 1-H

1

1

High-throughput

0.515

High

247086

TKT
Transketolase

1

0

High-throughput

0.513

High

247098

ARP2
Actin-related protein 2

1

0

High-throughput

0.513

High

247140

COMD1
COMM domain-containing protein 1

1

0

High-throughput

0.513

High

247156

ANR27
Ankyrin repeat domain-containing protein 27

1

0

High-throughput

0.513

High

247159

SOSB1
SOSS complex subunit B1

1

0

High-throughput

0.513

High

247163

MIS12
Protein MIS12 homolog

1

0

High-throughput

0.513

High

247184

NEUR2
Sialidase-2

1

0

High-throughput

0.513

High

247120

UPP1
Uridine phosphorylase 1

1

0

High-throughput

0.493

High

181669

CTDSL
CTD small phosphatase-like protein

1

2

High-throughput

0.489

High

247108

ROR1
Inactive tyrosine-protein kinase transmembrane receptor ROR1

1

20

Small-scale

0.489

High

247110

DSC1
Desmocollin-1

1

4

High-throughput

0.489

High

247121

PPR29
Protein phosphatase 1 regulatory subunit 29

1

5

High-throughput

0.489

High

247123

CF141
Uncharacterized protein C6orf141

1

1

High-throughput

0.489

High

247161

SPXN
Spexin

1

1

High-throughput

0.489

High

247168

LRC40
Leucine-rich repeat-containing protein 40

1

1

High-throughput

0.489

High

247185

EMIL1
EMILIN-1

1

1

High-throughput

0.489

High

247111

PIN1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

1

0

High-throughput

0.480

High

217575

TGON2
Trans-Golgi network integral membrane protein 2

1

5

High-throughput

0.479

High

247068

P53
Cellular tumor antigen p53

1

1

High-throughput

0.479

High

247071

K2C8
Keratin, type II cytoskeletal 8

1

3

High-throughput

0.479

High

247081

IKBA
NF-kappa-B inhibitor alpha

1

1

Small-scale

0.479

High

247090

STIP1
Stress-induced-phosphoprotein 1

1

1

High-throughput

0.479

High

247100

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

3

High-throughput

0.479

High

247112

HDAC1
Histone deacetylase 1

1

3

High-throughput

0.479

High

247124

RN123
E3 ubiquitin-protein ligase RNF123

1

3

High-throughput

0.479

High

247132

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

2

High-throughput

0.479

High

247134

TAXB1
Tax1-binding protein 1

1

4

High-throughput

0.479

High

247135

DYR2
Dihydrofolate reductase 2, mitochondrial

1

2

High-throughput

0.479

High

247152

AURKB
Aurora kinase B

1

6

High-throughput

0.479

High

247164

TOLIP
Toll-interacting protein

1

1

High-throughput

0.479

High

247167

EGLN3
Prolyl hydroxylase EGLN3

1

1

High-throughput

0.479

High

247172

DDX56
Probable ATP-dependent RNA helicase DDX56

1

2

High-throughput

0.479

High

247175

ZRAN1
Ubiquitin thioesterase ZRANB1

1

4

High-throughput

0.479

High

247182

NINL
Ninein-like protein

1

1

High-throughput

0.479

High

247077

H12
Histone H1.2

1

2

High-throughput

0.470

High

247118

H31T
Histone H3.1t

1

1

High-throughput

0.470

High

247155

EP400
E1A-binding protein p400

1

2

Small-scale

0.464

High

247083

MARK3
MAP/microtubule affinity-regulating kinase 3

1

0

Small-scale

0.458

High

247092

CDN1A
Cyclin-dependent kinase inhibitor 1

1

0

High-throughput

0.458

High

247117

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

0

High-throughput

0.458

High

247136

CEP57
Centrosomal protein of 57 kDa

1

0

High-throughput

0.458

High

247146

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

0

High-throughput

0.458

High

247174

CEP72
Centrosomal protein of 72 kDa

1

0

High-throughput

0.458

High

247179

DNPEP
Aspartyl aminopeptidase

1

0

High-throughput

0.458

High

247065

NFAT5
Nuclear factor of activated T-cells 5

1

1

Small-scale

0.457

High

247157

CK5P2
CDK5 regulatory subunit-associated protein 2

1

1

Small-scale

0.457

High

142245

PEX7
Peroxisomal targeting signal 2 receptor

1

2

High-throughput

0.445

High

247070

JUN
Transcription factor Jun

1

1

High-throughput

0.445

High

247072

CALM1
Calmodulin-1

1

7

High-throughput

0.445

High

247073

CALM2
Calmodulin-2

1

7

High-throughput

0.445

High

247074

CALM3
Calmodulin-3

1

7

High-throughput

0.445

High

247125

PKHA7
Pleckstrin homology domain-containing family A member 7

1

8

High-throughput

0.445

High

247142

LIPB2
Liprin-beta-2

1

1

High-throughput

0.445

High

247180

ZMIZ1
Zinc finger MIZ domain-containing protein 1

1

0

Small-scale

0.438

High

246322

KDM1A
Lysine-specific histone demethylase 1A

1

2

High-throughput

0.437

High

247063

CD123
Translation initiation factor eIF2 assembly protein

1

4

High-throughput

0.437

High

247064

RECQ4
ATP-dependent DNA helicase Q4

1

2

High-throughput

0.437

High

247066

MYC
Myc proto-oncogene protein

1

5

High-throughput

0.437

High

247067

NTRK1
High affinity nerve growth factor receptor

1

20

High-throughput

0.437

High

247075

H14
Histone H1.4

1

2

High-throughput

0.437

High

247076

RFA2
Replication protein A 32 kDa subunit

1

5

High-throughput

0.437

High

247084

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

4

High-throughput

0.437

High

247091

RFA3
Replication protein A 14 kDa subunit

1

4

High-throughput

0.437

High

247106

RNF4
E3 ubiquitin-protein ligase RNF4

1

3

High-throughput

0.437

High

247128

FBX42
F-box only protein 42

1

4

High-throughput

0.437

High

247130

TRI67
Tripartite motif-containing protein 67

1

8

High-throughput

0.437

High

247151

PF21A
PHD finger protein 21A

1

2

High-throughput

0.437

High

247166

PKHA4
Pleckstrin homology domain-containing family A member 4

1

6

High-throughput

0.437

High

247122

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

0

High-throughput

0.426

High

247145

TOPB1
DNA topoisomerase 2-binding protein 1

1

2

Small-scale

0.417

High

247131

CR3L2
Cyclic AMP-responsive element-binding protein 3-like protein 2

1

3

High-throughput

0.407

High

247107

FOXK1
Forkhead box protein K1

2

0

High-throughput

0.328

High

247115

DGCR6
Protein DGCR6

1

0

High-throughput

0.279

Low

247129

MBOA1
Membrane-bound glycerophospholipid O-acyltransferase 1

1

0

High-throughput

0.279

Low

247141

IQCF1
IQ domain-containing protein F1

1

0

High-throughput

0.279

Low

247148

FGF11
Fibroblast growth factor 11

1

0

High-throughput

0.279

Low

247153

ZN414
Zinc finger protein 414

1

0

High-throughput

0.279

Low

247154

CHAP1
Chromosome alignment-maintaining phosphoprotein 1

1

0

High-throughput

0.279

Low

247165

VPS16
Vacuolar protein sorting-associated protein 16 homolog

1

0

High-throughput

0.279

Low

247069

HMGN2
Non-histone chromosomal protein HMG-17

1

0

High-throughput

0.269

Low

175541

SR140
U2 snRNP-associated SURP motif-containing protein

1

0

Small-scale

0.265

Low

247126

TET2
Methylcytosine dioxygenase TET2

1

0

Small-scale

0.265

Low

247170

RBM12
RNA-binding protein 12

1

0

Small-scale

0.265

Low

247116

HAPR1
HUWE1-associated protein modifying stress responses 1

1

0

High-throughput

0.249

Low

247160

NOL10
Nucleolar protein 10

1

0

High-throughput

0.249

Low

244907

KATIP
Katanin-interacting protein

1

0

Small-scale

0.238

Low

247096

NDUA8
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8

1

0

High-throughput

0.238

Low

247143

NAV1
Neuron navigator 1

1

0

Small-scale

0.238

Low

247169

RESF1
Retroelement silencing factor 1

1

0

Small-scale

0.238

Low

247177

TASOR
Protein TASOR

1

0

Small-scale

0.238

Low

247137

SLX4
Structure-specific endonuclease subunit SLX4

1

0

High-throughput

0.232

Low

247183

S45A1
Proton-associated sugar transporter A

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025