HitPredict

Interactor 1: WASL (O00401)
Actin nucleation-promoting factor WASL (Neural Wiskott-Aldrich syndrome protein) (N-WASP)
Gene: WASL

Interactor 2: ITSN1 (Q15811)
Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17)
Gene: ITSN1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	11584276, 18539136
Identification Methods	pull down, coimmunoprecipitation, imaging technique
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0030027 - lamellipodium
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 505 Hs			1 1721
+	Hs
		203228 SYNJ1_HUMAN (4-500): 4.14e-62: 222: 14.85		ITSN1_HUMAN (1-1721): 0: 897: 100.00
+	Hs
		166049 SYNJ2_HUMAN (3-471): 6.56e-60: 215: 14.85		ITSN1_HUMAN (1-1721): 0: 897: 100.00
+	Hs
		790676 WASP_HUMAN (16-313): 7.4e-38: 147: 44.41		ITSN1_HUMAN (1-1721): 0: 897: 100.00
+	Rn
		94091 F1LSG0_RAT (379-485): 2.85e-30: 125: 95.33		ITSN1_RAT (1-1721): 0: 853: 92.27
+	Mm
		1225213 DEN1A_MOUSE (143-490): 6.46e-22: 101: 17.53		ITSN1_MOUSE (1-1721): 0: 864: 94.54
+	Hs
		166056 SYNJ2_HUMAN (3-471): 6.56e-60: 215: 14.85		ITSN2_HUMAN (1-1720): 0: 723: 54.73
+	Hs
		790688 WASP_HUMAN (16-313): 7.4e-38: 147: 44.41		ITSN2_HUMAN (1-1720): 0: 723: 54.73
+	Hs
		126965 WASL_HUMAN (378-485): 2.86e-29: 122: 100.00		ITSN2_HUMAN (1-1720): 0: 723: 54.73
+	Hs
		257713 ANR17_HUMAN (144-483): 4.19e-18: 90.2: 14.57		ITSN2_HUMAN (1-1720): 0: 723: 54.73
+	Hs
		195990 PLXB1_HUMAN (277-461): 1.76e-27: 119: 25.82		ARHGC_HUMAN (648-1635): 3.19e-67: 253: 15.32
+	Rn
		1126747 SYNJ1_RAT (4-505): 7.74e-69: 241: 13.31		Q5JC29_RAT (529-841): 5.46e-10: 66.6: 12.00
+	Hs
		203230 SYNJ1_HUMAN (4-500): 4.14e-62: 222: 14.85		SH319_HUMAN (1079-1218): 3.12e-09: 63.9: 28.57
+	Hs
		203208 SYNJ1_HUMAN (4-500): 4.14e-62: 222: 14.85		NCK1_HUMAN (895-1055): 6.44e-09: 62: 27.75
+	Dm
		112580 Q9VAT0_DROME (1-504): 8.78e-57: 199: 31.37		M9ND00_DROME (713-1252): 3.91e-15: 83.6: 12.73
+	Dm
		1361426 Q9VAT0_DROME (1-504): 8.78e-57: 199: 31.37		Q9VIF7_DROME (709-1252): 6.76e-15: 82.8: 12.46
+	Hs
		166030 SYNJ2_HUMAN (3-471): 6.56e-60: 215: 14.85		NCK1_HUMAN (895-1055): 6.44e-09: 62: 27.75
+	Mm
		936473 WASP_MOUSE (16-487): 4.45e-46: 170: 39.21		NCK1_MOUSE (889-1057): 2.15e-09: 63.5: 28.49
+	Hs
		167053 PLXB1_HUMAN (277-461): 1.76e-27: 119: 25.82		ARHGB_HUMAN (1231-1469): 2.58e-20: 100: 30.65
+	Hs
		557631 WASP_HUMAN (16-313): 7.4e-38: 147: 44.41		NCK1_HUMAN (895-1055): 6.44e-09: 62: 27.75
+	Hs
		126909 WASL_HUMAN (378-485): 2.86e-29: 122: 100.00		NCK1_HUMAN (895-1055): 6.44e-09: 62: 27.75