Protein: SCMC2
Mitochondrial adenyl nucleotide antiporter SLC25A25 (Mitochondrial ATP-Mg/Pi carrier protein 3) (Mitochondrial Ca(2+)-dependent solute carrier protein 3) (Short calcium-binding mitochondrial carrier protein 2) (SCaMC-2) (Solute carrier family 25 member 25)

Gene: SCMC2, SLC25A25
Organism: Homo sapiens
Interactions: 112
UniProt ID: Q6KCM7

Gene Ontology (top 5):
GO:0002021 - response to dietary excess
GO:0005347 - ATP transmembrane transporter activity
GO:0005509 - calcium ion binding
GO:0005739 - mitochondrion
GO:0005743 - mitochondrial inner membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1235739

SCMC3
Mitochondrial adenyl nucleotide antiporter SLC25A23

3

15

High-throughput

0.855

High

821732

CD79B
B-cell antigen receptor complex-associated protein beta chain

2

7

High-throughput

0.726

High

1235753

ST38L
Serine/threonine-protein kinase 38-like

2

6

High-throughput

0.726

High

1235741

CLPB
Mitochondrial disaggregase

2

6

High-throughput

0.712

High

1143159

PLEC
Plectin

1

0

High-throughput

0.631

High

1060880

LRP1
Prolow-density lipoprotein receptor-related protein 1

2

4

High-throughput

0.628

High

754045

CD80
T-lymphocyte activation antigen CD80

1

6

High-throughput

0.618

High

1142495

PDCD1
Programmed cell death protein 1

1

4

High-throughput

0.618

High

1235723

AQP3
Aquaporin-3

1

4

High-throughput

0.618

High

292150

S2512
Electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial

1

16

High-throughput

0.618

High

691775

MK03
Mitogen-activated protein kinase 3

1

13

High-throughput

0.618

High

703622

MK01
Mitogen-activated protein kinase 1

1

13

High-throughput

0.618

High

1235742

S2551
Mitochondrial nicotinamide adenine dinucleotide transporter SLC25A51

1

16

High-throughput

0.618

High

1235721

HUMMR
Protein MGARP

2

10

High-throughput

0.601

High

242003

PRKN
E3 ubiquitin-protein ligase parkin

2

10

High-throughput

0.584

High

348563

AIFM1
Apoptosis-inducing factor 1, mitochondrial

2

6

High-throughput

0.584

High

1235744

SFXN1
Sideroflexin-1

2

4

High-throughput

0.584

High

847408

GPDM
Glycerol-3-phosphate dehydrogenase, mitochondrial

1

6

High-throughput

0.575

High

1235733

MICU1
Calcium uptake protein 1, mitochondrial

1

12

High-throughput

0.575

High

854541

S15A1
Solute carrier family 15 member 1

2

4

High-throughput

0.574

High

1128904

I13R2
Interleukin-13 receptor subunit alpha-2

2

3

High-throughput

0.574

High

1235727

OMA1
Metalloendopeptidase OMA1, mitochondrial

2

3

High-throughput

0.571

High

1235724

MUL1
Mitochondrial ubiquitin ligase activator of NFKB 1

2

5

High-throughput

0.552

High

774422

BASI
Basigin

1

8

High-throughput

0.536

High

255077

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

2

High-throughput

0.514

High

317339

ACL6B
Actin-like protein 6B

1

1

High-throughput

0.514

High

182589

GP182
G-protein coupled receptor 182

1

20

High-throughput

0.489

High

250663

HNRPQ
Heterogeneous nuclear ribonucleoprotein Q

1

3

High-throughput

0.489

High

289324

FCN3
Ficolin-3

1

5

High-throughput

0.489

High

733002

VIPR1
Vasoactive intestinal polypeptide receptor 1

1

3

High-throughput

0.489

High

771148

APJ
Apelin receptor

1

13

High-throughput

0.489

High

845048

EAA3
Excitatory amino acid transporter 3

1

4

High-throughput

0.489

High

848504

MAGA8
Melanoma-associated antigen 8

1

7

High-throughput

0.489

High

1034753

NAAA
N-acylethanolamine-hydrolyzing acid amidase

1

4

High-throughput

0.489

High

1053008

VMAT2
Synaptic vesicular amine transporter

1

2

High-throughput

0.489

High

1116994

LAMB3
Laminin subunit beta-3

1

2

High-throughput

0.489

High

1235715

T150A
Transmembrane protein 150A

1

2

High-throughput

0.489

High

1235719

MFD4A
Major facilitator superfamily domain-containing protein 4A

1

4

High-throughput

0.489

High

1235732

SORT
Sortilin

1

1

High-throughput

0.489

High

1235754

GPR55
G-protein coupled receptor 55

1

20

High-throughput

0.489

High

1235755

KLK5
Kallikrein-5

1

15

High-throughput

0.489

High

559989

COX41
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

1

3

High-throughput

0.479

High

1235731

IMP1L
Mitochondrial inner membrane protease subunit 1

1

6

High-throughput

0.479

High

1235738

MIC26
MICOS complex subunit MIC26

1

6

High-throughput

0.479

High

1235743

PARL
Presenilin-associated rhomboid-like protein, mitochondrial

1

3

High-throughput

0.479

High

322839

MTCL2
Microtubule cross-linking factor 2

1

6

High-throughput

0.470

High

384447

CRYAA
Alpha-crystallin A chain

1

13

High-throughput

0.457

High

124378

HAX1
HCLS1-associated protein X-1

1

1

High-throughput

0.445

High

238715

TIM8A
Mitochondrial import inner membrane translocase subunit Tim8 A

1

8

High-throughput

0.445

High

245481

OPA1
Dynamin-like GTPase OPA1, mitochondrial

1

2

High-throughput

0.445

High

359826

DYR
Dihydrofolate reductase

1

2

High-throughput

0.445

High

553833

KCRU
Creatine kinase U-type, mitochondrial

1

2

High-throughput

0.445

High

605463

NDUB7
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7

1

2

High-throughput

0.445

High

653383

HEMH
Ferrochelatase, mitochondrial

1

2

High-throughput

0.445

High

784865

HEM6
Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial

1

1

High-throughput

0.445

High

932476

KAD2
Adenylate kinase 2, mitochondrial

1

2

High-throughput

0.445

High

1013405

LACTB
Serine beta-lactamase-like protein LACTB, mitochondrial

1

1

High-throughput

0.445

High

1124776

NUCG
Endonuclease G, mitochondrial

1

3

High-throughput

0.445

High

1231748

TTC19
Tetratricopeptide repeat protein 19, mitochondrial

1

2

High-throughput

0.445

High

1235716

SIR2
NAD-dependent protein deacetylase sirtuin-2

1

4

High-throughput

0.445

High

1235717

PUSL1
tRNA pseudouridine synthase-like 1

1

1

High-throughput

0.445

High

1235720

MIA40
Mitochondrial intermembrane space import and assembly protein 40

1

2

High-throughput

0.445

High

1235725

COA7
Cytochrome c oxidase assembly factor 7

1

1

High-throughput

0.445

High

1235728

MITOK
Mitochondrial potassium channel

1

1

High-throughput

0.445

High

1235745

PPA6
Lysophosphatidic acid phosphatase type 6

1

2

High-throughput

0.445

High

1235748

NDUAD
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13

1

2

High-throughput

0.445

High

1235752

EXOG
Nuclease EXOG, mitochondrial

1

3

High-throughput

0.445

High

1235756

TIM8B
Mitochondrial import inner membrane translocase subunit Tim8 B

1

8

High-throughput

0.445

High

1235757

TIM13
Mitochondrial import inner membrane translocase subunit Tim13

1

8

High-throughput

0.445

High

1235758

ATP23
Mitochondrial inner membrane protease ATP23 homolog

1

1

High-throughput

0.445

High

1235759

COX11
Cytochrome c oxidase assembly protein COX11, mitochondrial

1

1

High-throughput

0.445

High

293849

CD123
Translation initiation factor eIF2 assembly protein

1

6

High-throughput

0.437

High

1178200

CL16A
Protein CLEC16A

1

3

High-throughput

0.437

High

1235713

TRI67
Tripartite motif-containing protein 67

1

17

High-throughput

0.437

High

559691

UNG
Uracil-DNA glycosylase

1

0

High-throughput

0.426

High

1181300

PGPS1
CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial

1

0

High-throughput

0.426

High

1235714

ADCK2
Uncharacterized aarF domain-containing protein kinase 2

1

0

High-throughput

0.426

High

1235726

F136A
Protein FAM136A

1

0

High-throughput

0.426

High

1235729

SRAC1
Protein SERAC1

1

0

High-throughput

0.426

High

1235737

CHCH5
Coiled-coil-helix-coiled-coil-helix domain-containing protein 5

1

0

High-throughput

0.426

High

1235740

COA1
Cytochrome c oxidase assembly factor 1 homolog

1

0

High-throughput

0.426

High

1235747

OXSM
3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial

1

0

High-throughput

0.426

High

1235751

PRLD1
PRELI domain-containing protein 1, mitochondrial

1

0

High-throughput

0.426

High

127110

APBB1
Amyloid beta precursor protein binding family B member 1

1

1

High-throughput

0.407

High

245711

GANP
Germinal-center associated nuclear protein

1

1

High-throughput

0.407

High

258940

DNJA2
DnaJ homolog subfamily A member 2

1

5

High-throughput

0.407

High

277718

H2AY
Core histone macro-H2A.1

1

5

High-throughput

0.407

High

415643

HSPB1
Heat shock protein beta-1

1

13

High-throughput

0.407

High

604685

UBF1
Nucleolar transcription factor 1

1

5

High-throughput

0.407

High

842789

CDN2A
Cyclin-dependent kinase inhibitor 2A

1

7

High-throughput

0.407

High

910100

RND2
Rho-related GTP-binding protein RhoN

1

4

High-throughput

0.407

High

946148

MLF1
Myeloid leukemia factor 1

1

3

High-throughput

0.407

High

1039954

AKA12
A-kinase anchor protein 12

1

7

High-throughput

0.407

High

1105737

ADAM9
Disintegrin and metalloproteinase domain-containing protein 9

1

1

High-throughput

0.407

High

1153546

MLF2
Myeloid leukemia factor 2

1

3

High-throughput

0.407

High

1216215

H37
Histone H3-7

1

4

High-throughput

0.407

High

1235730

LLR1
Leucine-rich repeat protein 1

1

1

High-throughput

0.407

High

1235735

TBA1C
Tubulin alpha-1C chain

1

8

High-throughput

0.407

High

1235736

TIRR
Tudor-interacting repair regulator protein

1

1

High-throughput

0.407

High

1235750

XCT
Cystine/glutamate transporter

1

1

High-throughput

0.407

High

897036

MAP2
Methionine aminopeptidase 2

2

0

High-throughput

0.328

High

542549

TOP2A
DNA topoisomerase 2-alpha

1

0

High-throughput

0.232

Low

1129241

LAGE3
EKC/KEOPS complex subunit LAGE3

1

0

High-throughput

0.232

Low

1130901

PSF1
DNA replication complex GINS protein PSF1

1

0

High-throughput

0.232

Low

1228929

CRBG3
Very large A-kinase anchor protein

1

0

High-throughput

0.232

Low

1235711

GASP3
G protein-coupled receptor associated sorting protein 3

1

0

High-throughput

0.232

Low

1235712

POZP3
POM121 and ZP3 fusion protein

1

0

High-throughput

0.232

Low

1235718

LYPD1
Ly6/PLAUR domain-containing protein 1

1

0

High-throughput

0.232

Low

1235722

SKA2
Spindle and kinetochore-associated protein 2

1

0

High-throughput

0.232

Low

1235734

TCF25
Ribosome quality control complex subunit TCF25

1

0

High-throughput

0.232

Low

1235746

ZN331
Zinc finger protein 331

1

0

High-throughput

0.232

Low

1235749

EXTL2
Exostosin-like 2

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025