HitPredict

Interactor 1: ESR2 (Q92731)
Estrogen receptor beta (ER-beta) (Nuclear receptor subfamily 3 group A member 2)
Gene: ESR2

Interactor 2: PI3R4 (Q99570)
Phosphoinositide 3-kinase regulatory subunit 4 (PI3-kinase regulatory subunit 4) (EC 2.7.11.1) (PI3-kinase p150 subunit) (Phosphoinositide 3-kinase adaptor protein)
Gene: PIK3R4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.571

Property	Details
Experiments	29509190, 21182203
Identification Methods	affinity chromatography technology
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0043231 - intracellular membrane-bounded organelle
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 530 Hs			1 1358
+	Hs
		149132 ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00		CTRO_HUMAN (10-864): 4.4e-129: 442: 11.77
+	Hs
		148263 ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56		CTRO_HUMAN (10-864): 4.4e-129: 442: 11.77
+	Hs
		209465 ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00		PLRG1_HUMAN (774-1358): 1.08e-114: 371: 14.46
+	Hs
		1039133 ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00		KCC2D_HUMAN (24-470): 8.31e-101: 332: 14.91
+	Hs
		209373 ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56		PLRG1_HUMAN (774-1358): 1.08e-114: 371: 14.46
+	Hs
		1269712 ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00		STRN4_HUMAN (956-1272): 7.89e-58: 216: 19.76
+	Hs
		229911 ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56		NUAK1_HUMAN (6-311): 7.6e-74: 262: 21.20
+	Hs
		377307 GCR_HUMAN (3-495): 1.12e-103: 330: 22.64		KCC2D_HUMAN (24-470): 8.31e-101: 332: 14.91
+	Hs
		370515 ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56		STRN4_HUMAN (956-1272): 7.89e-58: 216: 19.76
+	Hs
		1025270 NR1H3_HUMAN (65-499): 1.77e-104: 322: 20.97		STRN4_HUMAN (956-1272): 7.89e-58: 216: 19.76
+	Hs
		209385 ANDR_HUMAN (149-407): 8.1e-38: 150: 32.59		PLRG1_HUMAN (774-1358): 1.08e-114: 371: 14.46