Protein: UBA3
NEDD8-activating enzyme E1 catalytic subunit (EC 6.2.1.64) (NEDD8-activating enzyme E1C) (Ubiquitin-activating enzyme E1C) (Ubiquitin-like modifier-activating enzyme 3) (Ubiquitin-activating enzyme 3)

Gene: UBA3
Organism: Homo sapiens
Interactions: 47
UniProt ID: Q8TBC4

Gene Ontology (top 5):
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0006508 - proteolysis

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

957447

UBC12
NEDD8-conjugating enzyme Ubc12

20

20

Small-scale

0.989

High

1110845

ULA1
NEDD8-activating enzyme E1 regulatory subunit

12

14

Small-scale

0.976

High

1348704

UBE2F
NEDD8-conjugating enzyme UBE2F

5

20

Small-scale

0.914

High

1348702

UBA3
NEDD8-activating enzyme E1 catalytic subunit

4

11

Small-scale

0.898

High

1154875

NEDD8
Ubiquitin-like protein NEDD8

4

6

Small-scale

0.890

High

242356

PRKN
E3 ubiquitin-protein ligase parkin

2

8

High-throughput

0.754

High

161884

IMPA2
Inositol monophosphatase 2

3

1

High-throughput

0.675

High

1348707

CPNE2
Copine-2

3

2

High-throughput

0.675

High

982256

UB2D2
Ubiquitin-conjugating enzyme E2 D2

1

19

High-throughput

0.647

High

1348708

MTNB
Methylthioribulose-1-phosphate dehydratase

3

0

High-throughput

0.638

High

931568

RD23A
UV excision repair protein RAD23 homolog A

1

8

Small-scale

0.618

High

931686

RD23B
UV excision repair protein RAD23 homolog B

1

11

Small-scale

0.618

High

1335940

ZBT44
Zinc finger and BTB domain-containing protein 44

2

2

High-throughput

0.611

High

1348711

DUS23
Dual specificity protein phosphatase 23

2

5

High-throughput

0.606

High

1088466

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

1

High-throughput

0.541

High

1334677

SERB1
SERPINE1 mRNA-binding protein 1

1

5

High-throughput

0.536

High

1348706

OPTN
Optineurin

1

1

High-throughput

0.536

High

1348709

FA81B
Protein FAM81B

1

1

High-throughput

0.536

High

1348710

UIMC1
BRCA1-A complex subunit RAP80

1

1

High-throughput

0.536

High

1348716

SAR1B
Small COPII coat GTPase SAR1B

1

4

High-throughput

0.536

High

422676

A4
Amyloid-beta precursor protein

1

4

High-throughput

0.515

High

253543

MUSC
Musculin

1

0

High-throughput

0.513

High

1137409

SUZ12
Polycomb protein SUZ12

1

0

High-throughput

0.513

High

185874

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

5

High-throughput

0.501

High

1348703

CUL5
Cullin-5

1

4

Small-scale

0.501

High

387443

APOE
Apolipoprotein E

1

0

High-throughput

0.493

High

1200315

ANR39
Ankyrin repeat domain-containing protein 39

1

4

High-throughput

0.489

High

1348713

LRTM1
Leucine-rich repeat and transmembrane domain-containing protein 1

1

1

High-throughput

0.489

High

246792

KDM1A
Lysine-specific histone demethylase 1A

1

0

High-throughput

0.486

High

1348705

TRI63
E3 ubiquitin-protein ligase TRIM63

1

11

High-throughput

0.481

High

1348712

TRI55
Tripartite motif-containing protein 55

1

13

High-throughput

0.481

High

1348714

RBX2
RING-box protein 2

1

0

Small-scale

0.480

High

401183

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

1

High-throughput

0.479

High

430155

JUN
Transcription factor Jun

1

8

High-throughput

0.479

High

718831

CCND2
G1/S-specific cyclin-D2

1

1

Small-scale

0.479

High

767275

MERL
Merlin

1

1

High-throughput

0.479

High

848285

MAGA3
Melanoma-associated antigen 3

1

2

Small-scale

0.479

High

1254751

TRI67
Tripartite motif-containing protein 67

1

12

High-throughput

0.479

High

1348715

HERC5
E3 ISG15--protein ligase HERC5

1

11

Small-scale

0.479

High

386004

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

0

High-throughput

0.458

High

404850

PRIO
Major prion protein

1

2

High-throughput

0.445

High

911014

IMA1
Importin subunit alpha-1

1

5

High-throughput

0.445

High

106324

APRIO
Alternative prion protein

1

3

High-throughput

0.437

High

768702

RFA3
Replication protein A 14 kDa subunit

1

5

High-throughput

0.437

High

249173

DSCAM
Cell adhesion molecule DSCAM

1

0

High-throughput

0.282

High

608311

EGLN
Endoglin

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025